Entrez Gene

Basic Information
Gene ID	3735
Name	KARS
Synonymous	lysyl-tRNA synthetase;KARS;lysyl-tRNA synthetase
Definition	lysRS\|lysine tRNA ligase\|lysine--tRNA ligase
Position	16q23.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1559C>A; p.A520D; 16:75628705-75628705	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1787C>T; p.S596F; 16:75627902-75627902	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.779A>C; p.E260A; 16:75635696-75635696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1441G>T; p.G481C; 16:75629525-75629525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1045G>A; p.D349N; 16:75631726-75631726	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1494G>A; p.A498A; 16:75629472-75629472	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1494G>A; p.A498A; 16:75629472-75629472	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1079-7C>T; p.?; 16:75631596-75631596	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1520G>A; p.R507Q; 16:75629446-75629446	prostate	carcinoma	Substitution - Missense
c.616C>A; p.L206M; 16:75635965-75635965	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.598C>T; p.P200S; 16:75635983-75635983	skin	malignant_melanoma	Substitution - Missense
c.1620G>A; p.G540G; 16:75628644-75628644	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.237C>T; p.I79I; 16:75640335-75640335	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1015G>A; p.E339K; 16:75631756-75631756	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1535T>C; p.F512S; 16:75629431-75629431	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1493C>T; p.A498V; 16:75629473-75629473	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1043_1048delACGATC; p.H348_D349delHD; 16:75631723-75631728	prostate	carcinoma	Deletion - In frame
c.131G>A; p.S44N; 16:75641655-75641655	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1020C>T; p.F340F; 16:75631751-75631751	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.919C>T; p.L307F; 16:75631852-75631852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.990G>A; p.T330T; 16:75631781-75631781	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.865G>T; p.E289*; 16:75634223-75634223	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1384A>C; p.I462L; 16:75630463-75630463	pancreas	carcinoma	Substitution - Missense
c.429C>T; p.I143I; 16:75636507-75636507	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.397C>T; p.H133Y; 16:75636539-75636539	skin	malignant_melanoma	Substitution - Missense
c.496G>A; p.E166K; 16:75636085-75636085	skin	malignant_melanoma	Substitution - Missense
c.367G>A; p.D123N; 16:75640205-75640205	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1167A>C; p.P389P; 16:75631501-75631501	breast	carcinoma	Substitution - coding silent
c.1084G>A; p.V362M; 16:75631584-75631584	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.121A>T; p.K41*; 16:75641665-75641665	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.636G>C; p.M212I; 16:75635945-75635945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.564T>A; p.P188P; 16:75636017-75636017	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1170C>T; p.P390P; 16:75631498-75631498	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.392G>C; p.R131T; 16:75636544-75636544	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.392G>C; p.R131T; 16:75636544-75636544	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1453C>T; p.R485C; 16:75629513-75629513	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>C; p.K249N; 16:75635728-75635728	urinary_tract; bladder	carcinoma	Substitution - Missense
c.967C>T; p.R323W; 16:75631804-75631804	central_nervous_system; brain	glioma	Substitution - Missense
c.137A>G; p.K46R; 16:75641649-75641649	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.137A>G; p.K46R; 16:75641649-75641649	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.600G>A; p.P200P; 16:75635981-75635981	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.238C>T; p.R80C; 16:75640334-75640334	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.165C>T; p.A55A; 16:75641621-75641621	skin	malignant_melanoma	Substitution - coding silent
c.532C>T; p.R178W; 16:75636049-75636049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1340T>G; p.L447R; 16:75630507-75630507	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1144G>A; p.A382T; 16:75631524-75631524	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1013G>T; p.C338F; 16:75631758-75631758	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.973G>T; p.E325*; 16:75631798-75631798	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.274G>T; p.E92*; 16:75640298-75640298	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.504A>T; p.E168D; 16:75636077-75636077	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1201G>T; p.E401*; 16:75631467-75631467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1652T>A; p.I551N; 16:75628612-75628612	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1338G>A; p.K446K; 16:75631168-75631168	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.682C>T; p.R228C; 16:75635793-75635793	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.959G>A; p.R320H; 16:75631812-75631812	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.506T>G; p.F169C; 16:75636075-75636075	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.506T>G; p.F169C; 16:75636075-75636075	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.533G>T; p.R178L; 16:75636048-75636048	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.753C>A; p.I251I; 16:75635722-75635722	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.483-2A>G; p.?; 16:75636100-75636100	liver	carcinoma	Unknown
c.1676C>T; p.T559M; 16:75628588-75628588	thyroid	carcinoma	Substitution - Missense
c.1725C>T; p.P575P; 16:75627964-75627964	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.211G>A; p.V71M; 16:75641575-75641575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.857A>G; p.Y286C; 16:75634231-75634231	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1570G>A; p.D524N; 16:75628694-75628694	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.443G>A; p.R148Q; 16:75636493-75636493	urinary_tract; bladder	carcinoma	Substitution - Missense
c.443G>A; p.R148Q; 16:75636493-75636493	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.210C>T; p.S70S; 16:75641576-75641576	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.879C>G; p.N293K; 16:75634209-75634209	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1150G>A; p.D384N; 16:75631518-75631518	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.210C>T; p.S70S; 16:75641576-75641576	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1492G>A; p.A498T; 16:75629474-75629474	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1653T>C; p.I551I; 16:75628611-75628611	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.445G>A; p.G149R; 16:75636491-75636491	skin	malignant_melanoma	Substitution - Missense
c.784G>T; p.G262*; 16:75635691-75635691	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.599C>T; p.P200L; 16:75635982-75635982	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.599C>T; p.P200L; 16:75635982-75635982	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1044C>T; p.H348H; 16:75631727-75631727	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.599C>T; p.P200L; 16:75635982-75635982	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.43G>A; p.E15K; 16:75647597-75647597	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1725C>G; p.P575P; 16:75627964-75627964	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.691T>C; p.Y231H; 16:75635784-75635784	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.453G>T; p.G151G; 16:75636483-75636483	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1213G>T; p.G405W; 16:75631455-75631455	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.979A>T; p.I327F; 16:75631792-75631792	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1373A>G; p.N458S; 16:75630474-75630474	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.335A>G; p.Y112C; 16:75640237-75640237	liver	carcinoma	Substitution - Missense
c.835G>A; p.V279M; 16:75634253-75634253	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1267C>A; p.L423I; 16:75631239-75631239	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>C; p.E267Q; 16:75634289-75634289	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.653T>G; p.F218C; 16:75635928-75635928	lung	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]