Entrez Gene

Basic Information
Gene ID	3655
Name	ITGA6
Synonymous	integrin, alpha 6;ITGA6;integrin, alpha 6
Definition	CD49 antigen-like family member F\|integrin alpha-6\|integrin alpha6B
Position	2q31.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.633T>C; p.Y211Y; 2:172469370-172469370	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2835C>T; p.D945D; 2:172491277-172491277	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2399C>T; p.S800L; 2:172488035-172488035	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1227C>A; p.I409I; 2:172475643-172475643	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3033G>A; p.S1011S; 2:172498019-172498019	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2952T>C; p.A984A; 2:172491487-172491487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2324+1G>A; p.?; 2:172487808-172487808	lung	carcinoma; adenocarcinoma	Unknown
c.907C>T; p.P303S; 2:172474186-172474186	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.907C>T; p.P303S; 2:172474186-172474186	skin	malignant_melanoma	Substitution - Missense
c.2611G>C; p.V871L; 2:172489590-172489590	liver	carcinoma	Substitution - Missense
c.1091T>C; p.V364A; 2:172475033-172475033	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2407G>A; p.A803T; 2:172488130-172488130	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.523T>G; p.C175G; 2:172469260-172469260	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.745C>A; p.L249I; 2:172471075-172471075	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3047G>T; p.W1016L; 2:172498033-172498033	pancreas	carcinoma	Substitution - Missense
c.2480G>A; p.G827E; 2:172488203-172488203	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1826C>T; p.S609L; 2:172485236-172485236	pancreas	carcinoma	Substitution - Missense
c.2382A>G; p.E794E; 2:172488018-172488018	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.865G>A; p.V289M; 2:172474144-172474144	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2686C>T; p.H896Y; 2:172491030-172491030	oesophagus	carcinoma	Substitution - Missense
c.2686C>T; p.H896Y; 2:172491030-172491030	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2745T>G; p.F915L; 2:172491089-172491089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.666G>C; p.K222N; 2:172470996-172470996	breast	carcinoma	Substitution - Missense
c.2686C>T; p.H896Y; 2:172491030-172491030	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.658G>C; p.E220Q; 2:172470988-172470988	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1306A>G; p.I436V; 2:172476431-172476431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2347G>T; p.A783S; 2:172487983-172487983	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1269G>A; p.Q423Q; 2:172475685-172475685	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3050T>C; p.I1017T; 2:172498036-172498036	breast	carcinoma	Substitution - Missense
c.258C>T; p.C86C; 2:172465614-172465614	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.509G>A; p.G170E; 2:172469246-172469246	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.509G>A; p.G170E; 2:172469246-172469246	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2728G>C; p.D910H; 2:172491072-172491072	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1453C>A; p.Q485K; 2:172479705-172479705	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1487+7A>G; p.?; 2:172479746-172479746	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1487+7A>G; p.?; 2:172479746-172479746	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1487+7A>G; p.?; 2:172479746-172479746	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1786C>T; p.R596*; 2:172485196-172485196	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.538A>T; p.R180*; 2:172469275-172469275	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Nonsense
c.1177C>A; p.P393T; 2:172475119-172475119	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1414A>T; p.K472*; 2:172479666-172479666	lung	carcinoma; non_small_cell_carcinoma	Substitution - Nonsense
c.1255A>T; p.T419S; 2:172475671-172475671	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1464G>A; p.A488A; 2:172479716-172479716	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2119A>T; p.T707S; 2:172487412-172487412	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1464G>A; p.A488A; 2:172479716-172479716	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1836C>T; p.P612P; 2:172485246-172485246	skin	malignant_melanoma	Substitution - coding silent
c.1618C>T; p.R540*; 2:172484850-172484850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1618C>T; p.R540*; 2:172484850-172484850	skin	malignant_melanoma	Substitution - Nonsense
c.1207G>A; p.D403N; 2:172475623-172475623	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2045C>A; p.P682H; 2:172487338-172487338	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2405T>C; p.V802A; 2:172488128-172488128	skin	malignant_melanoma	Substitution - Missense
c.1872G>A; p.E624E; 2:172487040-172487040	skin	malignant_melanoma	Substitution - coding silent
c.238A>G; p.T80A; 2:172465594-172465594	liver	carcinoma	Substitution - Missense
c.238A>G; p.T80A; 2:172465594-172465594	liver	carcinoma	Substitution - Missense
c.1762A>G; p.I588V; 2:172485172-172485172	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2028A>T; p.I676I; 2:172487321-172487321	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1473G>A; p.A491A; 2:172479725-172479725	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.663A>G; p.Q221Q; 2:172470993-172470993	liver	carcinoma	Substitution - coding silent
c.1586G>T; p.R529I; 2:172484818-172484818	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.315C>T; p.P105P; 2:172467488-172467488	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1138G>A; p.A380T; 2:172475080-172475080	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1138G>A; p.A380T; 2:172475080-172475080	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2618C>G; p.S873C; 2:172489597-172489597	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.496G>T; p.D166Y; 2:172469233-172469233	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1354G>T; p.V452F; 2:172476479-172476479	skin	malignant_melanoma	Substitution - Missense
c.675_676insT; p.D228fs*1; 2:172471005-172471006	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.44G>T; p.G15V; 2:172427832-172427832	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1374A>G; p.S458S; 2:172476499-172476499	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.603T>G; p.H201Q; 2:172469340-172469340	pancreas	other; adenoma	Substitution - Missense
c.752C>T; p.P251L; 2:172471082-172471082	liver	carcinoma	Substitution - Missense
c.752C>T; p.P251L; 2:172471082-172471082	liver	carcinoma	Substitution - Missense
c.2796G>C; p.V932V; 2:172491238-172491238	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.951C>A; p.G317G; 2:172474230-172474230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2680G>C; p.E894Q; 2:172491024-172491024	skin	malignant_melanoma	Substitution - Missense
c.138C>T; p.F46F; 2:172427926-172427926	thyroid	carcinoma	Substitution - coding silent
c.819G>T; p.E273D; 2:172474098-172474098	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1918T>C; p.Y640H; 2:172487086-172487086	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.963G>A; p.A321A; 2:172474242-172474242	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2082C>T; p.D694D; 2:172487375-172487375	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2082C>T; p.D694D; 2:172487375-172487375	thyroid	other; neoplasm	Substitution - coding silent
c.963G>A; p.A321A; 2:172474242-172474242	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2956G>A; p.E986K; 2:172491491-172491491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2335C>G; p.Q779E; 2:172487971-172487971	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2671A>G; p.N891D; 2:172489650-172489650	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2302G>A; p.D768N; 2:172487785-172487785	skin	malignant_melanoma	Substitution - Missense
c.604T>C; p.Y202H; 2:172469341-172469341	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2611G>T; p.V871L; 2:172489590-172489590	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2890-1G>T; p.?; 2:172491424-172491424	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1651G>C; p.E551Q; 2:172484883-172484883	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2538C>T; p.L846L; 2:172489517-172489517	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2858_2869del12; p.S954_W957delSRLW; 2:172491300-172491311	breast	carcinoma	Deletion - In frame
c.962C>T; p.A321V; 2:172474241-172474241	pancreas	carcinoma	Substitution - Missense
c.1281T>C; p.G427G; 2:172476406-172476406	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2285T>C; p.F762S; 2:172487768-172487768	liver	carcinoma	Substitution - Missense
c.2794G>A; p.V932M; 2:172491236-172491236	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2285T>C; p.F762S; 2:172487768-172487768	liver	carcinoma	Substitution - Missense
c.2217C>G; p.L739L; 2:172487603-172487603	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.675delT; p.F227fs*3; 2:172471005-172471005	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.373G>A; p.G125R; 2:172467546-172467546	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2766A>G; p.K922K; 2:172491110-172491110	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.120C>T; p.P40P; 2:172427908-172427908	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1802C>A; p.P601Q; 2:172485212-172485212	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.467T>C; p.V156A; 2:172469204-172469204	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2136A>T; p.A712A; 2:172487429-172487429	thyroid	other; neoplasm	Substitution - coding silent
c.1861T>G; p.F621V; 2:172487029-172487029	skin	malignant_melanoma	Substitution - Missense
c.1499A>G; p.K500R; 2:172480001-172480001	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1723G>A; p.D575N; 2:172485133-172485133	breast	carcinoma	Substitution - Missense
c.2316G>C; p.K772N; 2:172487799-172487799	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2747C>A; p.S916Y; 2:172491091-172491091	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2746T>G; p.S916A; 2:172491090-172491090	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.689A>C; p.N230T; 2:172471019-172471019	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3221A>T; p.*1074L; 2:172501878-172501878	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Nonstop extension
c.3129G>C; p.K1043N; 2:172501786-172501786	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1721G>C; p.R574T; 2:172485131-172485131	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1721G>C; p.R574T; 2:172485131-172485131	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2741A>C; p.K914T; 2:172491085-172491085	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1876T>C; p.C626R; 2:172487044-172487044	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2844G>A; p.A948A; 2:172491286-172491286	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1930A>T; p.T644S; 2:172487098-172487098	skin	malignant_melanoma	Substitution - Missense
c.132C>T; p.F44F; 2:172427920-172427920	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.471G>T; p.L157L; 2:172469208-172469208	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1415A>T; p.K472I; 2:172479667-172479667	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.639G>A; p.W213*; 2:172469376-172469376	skin	malignant_melanoma	Substitution - Nonsense
c.1137T>C; p.I379I; 2:172475079-172475079	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2109G>A; p.T703T; 2:172487402-172487402	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2109G>A; p.T703T; 2:172487402-172487402	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1712A>T; p.D571V; 2:172485122-172485122	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.318G>A; p.T106T; 2:172467491-172467491	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2452C>A; p.Q818K; 2:172488175-172488175	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1463C>T; p.A488V; 2:172479715-172479715	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.317C>T; p.T106M; 2:172467490-172467490	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2897C>T; p.S966F; 2:172491432-172491432	skin	malignant_melanoma	Substitution - Missense
c.496G>A; p.D166N; 2:172469233-172469233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.317C>T; p.T106M; 2:172467490-172467490	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.700G>A; p.D234N; 2:172471030-172471030	breast	carcinoma	Substitution - Missense
c.42G>A; p.A14A; 2:172427830-172427830	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1711-16_1718del24; p.?; 2:172485105-172485128	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.2064C>T; p.P688P; 2:172487357-172487357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1454A>G; p.Q485R; 2:172479706-172479706	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.760G>T; p.A254S; 2:172471090-172471090	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1821G>A; p.L607L; 2:172485231-172485231	skin	malignant_melanoma	Substitution - coding silent
c.287G>A; p.R96Q; 2:172465643-172465643	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2188C>T; p.Q730*; 2:172487574-172487574	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1604C>G; p.S535*; 2:172484836-172484836	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2742A>G; p.K914K; 2:172491086-172491086	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2698A>G; p.K900E; 2:172491042-172491042	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1896T>C; p.C632C; 2:172487064-172487064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2160+1delG; p.?; 2:172487454-172487454	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.987-1G>C; p.?; 2:172474928-172474928	lung	carcinoma; adenocarcinoma	Unknown
c.1331G>A; p.R444Q; 2:172476456-172476456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3126C>G; p.F1042L; 2:172501783-172501783	large_intestine; colon	adenoma	Substitution - Missense
c.2572G>T; p.E858*; 2:172489551-172489551	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.308C>T; p.A103V; 2:172467481-172467481	breast	carcinoma	Substitution - Missense
c.2572G>T; p.E858*; 2:172489551-172489551	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2862G>A; p.S954S; 2:172491304-172491304	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.442C>T; p.R148*; 2:172469179-172469179	large_intestine; colon	carcinoma	Substitution - Nonsense
c.1987G>C; p.E663Q; 2:172487280-172487280	prostate	carcinoma	Substitution - Missense
c.284C>A; p.T95K; 2:172465640-172465640	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.442C>T; p.R148*; 2:172469179-172469179	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2543C>A; p.T848K; 2:172489522-172489522	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2696G>A; p.R899K; 2:172491040-172491040	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1619G>A; p.R540Q; 2:172484851-172484851	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1139C>T; p.A380V; 2:172475081-172475081	NS	NS	Substitution - Missense
c.1503C>T; p.S501S; 2:172480005-172480005	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1619G>A; p.R540Q; 2:172484851-172484851	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1619G>A; p.R540Q; 2:172484851-172484851	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2225C>T; p.P742L; 2:172487611-172487611	skin	malignant_melanoma	Substitution - Missense
c.879G>C; p.K293N; 2:172474158-172474158	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2849T>C; p.L950P; 2:172491291-172491291	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1028G>A; p.R343K; 2:172474970-172474970	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]