Entrez Gene

Basic Information
Gene ID	3549
Name	IHH
Synonymous	indian hedgehog;IHH;indian hedgehog
Definition	HHG-2\|Indian hedgehog homolog\|indian hedgehog protein
Position	2q33-q35
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.655G>A; p.A219T; 2:219055788-219055788	skin	malignant_melanoma	Substitution - Missense
c.292G>A; p.G98S; 2:219060176-219060176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1044C>T; p.F348F; 2:219055399-219055399	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1044C>T; p.F348F; 2:219055399-219055399	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.19C>T; p.R7W; 2:219060449-219060449	skin	malignant_melanoma	Substitution - Missense
c.632G>A; p.R211H; 2:219055811-219055811	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.892G>A; p.V298M; 2:219055551-219055551	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.851C>T; p.T284M; 2:219055592-219055592	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1131G>A; p.P377P; 2:219055312-219055312	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.665C>T; p.A222V; 2:219055778-219055778	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.599C>T; p.T200M; 2:219055844-219055844	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1011A>C; p.T337T; 2:219055432-219055432	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.167T>C; p.V56A; 2:219060301-219060301	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.124C>T; p.R42C; 2:219060344-219060344	urinary_tract; bladder	carcinoma	Substitution - Missense
c.746G>A; p.R249H; 2:219055697-219055697	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.748G>T; p.E250*; 2:219055695-219055695	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.447C>T; p.R149R; 2:219057563-219057563	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.447C>T; p.R149R; 2:219057563-219057563	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1156delC; p.Q386fs*11; 2:219055287-219055287	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1156delC; p.Q386fs*11; 2:219055287-219055287	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1156delC; p.Q386fs*11; 2:219055287-219055287	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1156_1157insC; p.Q386fs*>27; 2:219055286-219055287	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.247C>A; p.P83T; 2:219060221-219060221	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.603C>T; p.G201G; 2:219055840-219055840	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.603C>T; p.G201G; 2:219055840-219055840	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.738C>T; p.F246F; 2:219055705-219055705	skin	malignant_melanoma	Substitution - coding silent
c.647C>T; p.A216V; 2:219055796-219055796	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.444C>T; p.G148G; 2:219057566-219057566	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.559C>T; p.H187Y; 2:219057451-219057451	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.675G>A; p.P225P; 2:219055768-219055768	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.123A>G; p.P41P; 2:219060345-219060345	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.109C>A; p.R37S; 2:219060359-219060359	thyroid	other; neoplasm	Substitution - Missense
c.390C>G; p.T130T; 2:219057620-219057620	pancreas	carcinoma	Substitution - coding silent
c.1175G>A; p.G392E; 2:219055268-219055268	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1129C>T; p.P377S; 2:219055314-219055314	skin	malignant_melanoma	Substitution - Missense
c.670A>G; p.R224G; 2:219055773-219055773	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.218G>A; p.R73H; 2:219060250-219060250	urinary_tract; bladder	carcinoma	Substitution - Missense
c.838delG; p.A280fs*85; 2:219055605-219055605	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1138G>A; p.G380S; 2:219055305-219055305	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.990C>T; p.A330A; 2:219055453-219055453	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.503G>A; p.R168H; 2:219057507-219057507	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1063C>T; p.H355Y; 2:219055380-219055380	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.775G>A; p.V259I; 2:219055668-219055668	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.869T>C; p.F290S; 2:219055574-219055574	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.403G>A; p.E135K; 2:219057607-219057607	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.910G>A; p.V304M; 2:219055533-219055533	liver	carcinoma	Substitution - Missense
c.910G>A; p.V304M; 2:219055533-219055533	liver	carcinoma	Substitution - Missense
c.445C>T; p.R149C; 2:219057565-219057565	skin; trunk	malignant_melanoma	Substitution - Missense
c.116G>C; p.R39P; 2:219060352-219060352	breast	carcinoma	Substitution - Missense
c.113G>C; p.R38P; 2:219060355-219060355	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.486G>A; p.K162K; 2:219057524-219057524	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.584C>T; p.S195L; 2:219055859-219055859	skin	malignant_melanoma	Substitution - Missense
c.58C>G; p.L20V; 2:219060410-219060410	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.58C>G; p.L20V; 2:219060410-219060410	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.795C>T; p.P265P; 2:219055648-219055648	skin	malignant_melanoma	Substitution - coding silent
c.781G>A; p.E261K; 2:219055662-219055662	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.909C>T; p.Y303Y; 2:219055534-219055534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.762G>A; p.L254L; 2:219055681-219055681	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1050C>T; p.A350A; 2:219055393-219055393	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.707G>T; p.G236V; 2:219055736-219055736	pancreas	carcinoma	Substitution - Missense
c.1128T>C; p.T376T; 2:219055315-219055315	breast	carcinoma	Substitution - coding silent
c.1128T>C; p.T376T; 2:219055315-219055315	thyroid	other; neoplasm	Substitution - coding silent
c.600G>A; p.T200T; 2:219055843-219055843	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.762G>C; p.L254L; 2:219055681-219055681	breast	carcinoma	Substitution - coding silent
c.835A>G; p.T279A; 2:219055608-219055608	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.666C>T; p.A222A; 2:219055777-219055777	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.194G>A; p.G65E; 2:219060274-219060274	breast	carcinoma	Substitution - Missense
c.683G>A; p.R228H; 2:219055760-219055760	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.165T>C; p.N55N; 2:219060303-219060303	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.419C>T; p.S140L; 2:219057591-219057591	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.831_832insCCCTGCTC; p.F278fs*90; 2:219055611-219055612	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.1134_1135GG>AA; p.E379K; 2:219055308-219055309	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.757_760delAGGC; p.R253fs*1; 2:219055683-219055686	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.797delC; p.P266fs*99; 2:219055646-219055646	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.797delC; p.P266fs*99; 2:219055646-219055646	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.429C>A; p.S143S; 2:219057581-219057581	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1136A>G; p.E379G; 2:219055307-219055307	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.648G>A; p.A216A; 2:219055795-219055795	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1135G>A; p.E379K; 2:219055308-219055308	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.667G>A; p.V223M; 2:219055776-219055776	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1135G>A; p.E379K; 2:219055308-219055308	skin	malignant_melanoma	Substitution - Missense
c.1143G>T; p.V381V; 2:219055300-219055300	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.639G>A; p.E213E; 2:219055804-219055804	skin	malignant_melanoma	Substitution - coding silent
c.992C>T; p.P331L; 2:219055451-219055451	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.992C>T; p.P331L; 2:219055451-219055451	skin	malignant_melanoma	Substitution - Missense
c.98T>G; p.V33G; 2:219060370-219060370	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1034C>T; p.A345V; 2:219055409-219055409	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.125G>A; p.R42H; 2:219060343-219060343	thyroid	other; neoplasm	Substitution - Missense
c.943G>A; p.A315T; 2:219055500-219055500	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense

COSMIC somatic mutation [Top]