| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3487 |
Name | IGFBP4 |
Synonymous | insulin-like growth factor binding protein 4;IGFBP4;insulin-like growth factor binding protein 4 |
Definition | IBP-4|IGF-binding protein 4|insulin-like growth factor-binding protein 4 |
Position | 17q21.2 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.518C>T; p.S173F; 17:40453938-40453938 |
skin; mucosal | malignant_melanoma | Substitution - Missense |
c.557_558delCC; p.A186fs*68; 17:40453977-40453978 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Deletion - Frameshift |
c.508-1G>T; p.?; 17:40453927-40453927 |
endometrium | carcinoma; endometrioid_carcinoma | Unknown |
c.733G>T; p.G245W; 17:40456539-40456539 |
upper_aerodigestive_tract; mouth | carcinoma | Substitution - Missense |
c.733G>T; p.G245W; 17:40456539-40456539 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.539G>T; p.R180L; 17:40453959-40453959 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.660T>C; p.D220D; 17:40456466-40456466 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.478G>A; p.G160R; 17:40453113-40453113 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.507+5G>A; p.?; 17:40453147-40453147 |
ovary | other; neoplasm | Unknown |
c.509C>T; p.P170L; 17:40453929-40453929 |
oesophagus | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.124G>A; p.V42M; 17:40443859-40443859 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.489G>A; p.R163R; 17:40453124-40453124 |
skin | malignant_melanoma | Substitution - coding silent |
c.598C>T; p.P200S; 17:40454018-40454018 |
NS | NS | Substitution - Missense |
c.617G>A; p.R206H; 17:40454037-40454037 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.693G>A; p.R231R; 17:40456499-40456499 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.543G>T; p.A181A; 17:40453963-40453963 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.579C>T; p.H193H; 17:40453999-40453999 |
pancreas | carcinoma | Substitution - coding silent |
c.358G>A; p.E120K; 17:40452993-40452993 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.436A>C; p.I146L; 17:40453071-40453071 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.697A>T; p.T233S; 17:40456503-40456503 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.640C>T; p.Q214*; 17:40454060-40454060 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.529G>A; p.E177K; 17:40453949-40453949 |
breast | carcinoma | Substitution - Missense |
c.604C>T; p.P202S; 17:40454024-40454024 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.117delC; p.V42fs*52; 17:40443852-40443852 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.117delC; p.V42fs*52; 17:40443852-40443852 |
pancreas | carcinoma; acinar_carcinoma | Deletion - Frameshift |
c.117delC; p.V42fs*52; 17:40443852-40443852 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.117delC; p.V42fs*52; 17:40443852-40443852 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.580G>A; p.E194K; 17:40454000-40454000 |
skin | malignant_melanoma | Substitution - Missense |
c.33G>A; p.L11L; 17:40443768-40443768 |
stomach | carcinoma; diffuse_adenocarcinoma | Substitution - coding silent |
c.737A>G; p.E246G; 17:40456543-40456543 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.733G>A; p.G245R; 17:40456539-40456539 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.740T>G; p.L247R; 17:40456546-40456546 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.528C>T; p.S176S; 17:40453948-40453948 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.482C>T; p.A161V; 17:40453117-40453117 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.577C>T; p.H193Y; 17:40453997-40453997 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.490G>T; p.E164*; 17:40453125-40453125 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.105G>A; p.L35L; 17:40443840-40443840 |
thyroid | other; neoplasm | Substitution - coding silent |
c.105G>A; p.L35L; 17:40443840-40443840 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.105G>A; p.L35L; 17:40443840-40443840 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.105G>A; p.L35L; 17:40443840-40443840 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.712C>T; p.P238S; 17:40456518-40456518 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.599C>T; p.P200L; 17:40454019-40454019 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |