Entrez Gene

Basic Information
Gene ID	2817
Name	GPC1
Synonymous	glypican 1;GPC1;glypican 1
Definition	glypican proteoglycan 1\|glypican-1
Position	2q35-q37
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1377G>T; p.Q459H; 2:240465581-240465581	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1667G>A; p.R556Q; 2:240466280-240466280	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1059C>T; p.P353P; 2:240464900-240464900	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.683G>A; p.G228D; 2:240462548-240462548	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>A; p.V95I; 2:240459146-240459146	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.968A>G; p.E323G; 2:240464700-240464700	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.818G>A; p.R273Q; 2:240463447-240463447	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.679C>A; p.L227M; 2:240462544-240462544	thyroid	other; neoplasm	Substitution - Missense
c.522C>A; p.L174L; 2:240462387-240462387	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.325+9C>A; p.?; 2:240459197-240459197	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.723C>T; p.P241P; 2:240463352-240463352	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1520G>A; p.S507N; 2:240466133-240466133	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.348C>T; p.N116N; 2:240462213-240462213	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1311C>T; p.I437I; 2:240465515-240465515	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.799C>T; p.P267S; 2:240463428-240463428	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1613C>T; p.P538L; 2:240466226-240466226	skin	malignant_melanoma	Substitution - Missense
c.1613C>T; p.P538L; 2:240466226-240466226	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.858G>C; p.L286L; 2:240463487-240463487	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1578A>G; p.G526G; 2:240466191-240466191	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1621C>T; p.L541F; 2:240466234-240466234	skin	malignant_melanoma	Substitution - Missense
c.88C>G; p.R30G; 2:240436006-240436006	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1161C>T; p.R387R; 2:240465103-240465103	large_intestine; colon	adenoma	Substitution - coding silent
c.1161C>T; p.R387R; 2:240465103-240465103	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1609C>T; p.P537S; 2:240466222-240466222	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.677G>C; p.G226A; 2:240462542-240462542	thyroid	other; neoplasm	Substitution - Missense
c.1246T>G; p.W416G; 2:240465188-240465188	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1498A>G; p.S500G; 2:240466111-240466111	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1498A>G; p.S500G; 2:240466111-240466111	thyroid	other; neoplasm	Substitution - Missense
c.1321G>A; p.E441K; 2:240465525-240465525	skin	malignant_melanoma	Substitution - Missense
c.405G>A; p.T135T; 2:240462270-240462270	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1572G>T; p.Q524H; 2:240466185-240466185	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1308G>C; p.Q436H; 2:240465512-240465512	urinary_tract; bladder	carcinoma	Substitution - Missense
c.452A>G; p.Y151C; 2:240462317-240462317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1079G>A; p.R360H; 2:240464920-240464920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.732G>A; p.P244P; 2:240463361-240463361	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.694G>T; p.D232Y; 2:240462559-240462559	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.904G>A; p.D302N; 2:240464636-240464636	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.506G>A; p.R169H; 2:240462371-240462371	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.820A>C; p.N274H; 2:240463449-240463449	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1162G>A; p.D388N; 2:240465104-240465104	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1252G>A; p.G418R; 2:240465194-240465194	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.459C>T; p.R153R; 2:240462324-240462324	breast	carcinoma	Substitution - coding silent
c.459C>T; p.R153R; 2:240462324-240462324	thyroid	other; neoplasm	Substitution - coding silent
c.459C>T; p.R153R; 2:240462324-240462324	thyroid	other; neoplasm	Substitution - coding silent
c.721C>T; p.P241S; 2:240463350-240463350	skin	malignant_melanoma	Substitution - Missense
c.445C>T; p.R149C; 2:240462310-240462310	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1442C>T; p.A481V; 2:240465646-240465646	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1662G>A; p.R554R; 2:240466275-240466275	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.750C>G; p.V250V; 2:240463379-240463379	thyroid	carcinoma	Substitution - coding silent
c.1449C>T; p.D483D; 2:240466062-240466062	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.358C>T; p.R120W; 2:240462223-240462223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.862G>A; p.A288T; 2:240463491-240463491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.593C>T; p.A198V; 2:240462458-240462458	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1508T>G; p.V503G; 2:240466121-240466121	ovary	other; neoplasm	Substitution - Missense
c.1010C>A; p.A337D; 2:240464742-240464742	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.416G>A; p.R139K; 2:240462281-240462281	skin	malignant_melanoma	Substitution - Missense
c.628C>T; p.R210C; 2:240462493-240462493	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.628C>T; p.R210C; 2:240462493-240462493	large_intestine; colon	carcinoma	Substitution - Missense
c.1455C>T; p.G485G; 2:240466068-240466068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.628C>T; p.R210C; 2:240462493-240462493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.628C>T; p.R210C; 2:240462493-240462493	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.192G>T; p.Q64H; 2:240459055-240459055	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1193G>T; p.G398V; 2:240465135-240465135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1140C>T; p.S380S; 2:240465082-240465082	breast	carcinoma	Substitution - coding silent
c.1140C>T; p.S380S; 2:240465082-240465082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.503C>T; p.A168V; 2:240462368-240462368	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1140C>T; p.S380S; 2:240465082-240465082	thyroid	other; neoplasm	Substitution - coding silent
c.793G>A; p.A265T; 2:240463422-240463422	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1529_1530CC>TT; p.S510F; 2:240466142-240466143	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.263C>T; p.A88V; 2:240459126-240459126	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1640T>A; p.F547Y; 2:240466253-240466253	skin	malignant_melanoma	Substitution - Missense
c.666C>T; p.S222S; 2:240462531-240462531	skin	malignant_melanoma	Substitution - coding silent
c.280C>T; p.R94C; 2:240459143-240459143	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.280C>T; p.R94C; 2:240459143-240459143	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.280C>T; p.R94C; 2:240459143-240459143	large_intestine; colon	carcinoma	Substitution - Missense
c.280C>T; p.R94C; 2:240459143-240459143	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1079G>T; p.R360L; 2:240464920-240464920	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1300G>A; p.A434T; 2:240465504-240465504	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.321C>T; p.F107F; 2:240459184-240459184	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.321C>T; p.F107F; 2:240459184-240459184	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.685G>A; p.V229M; 2:240462550-240462550	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.198C>A; p.Y66*; 2:240459061-240459061	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense

COSMIC somatic mutation [Top]