| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2798 |
Name | GNRHR |
Synonymous | gonadotropin-releasing hormone receptor;GNRHR;gonadotropin-releasing hormone receptor |
Definition | gnRH receptor|gnRH-R|gonadotropin-releasing hormone (type 1) receptor 1|leutinizing hormone releasing horomone receptor|leutinizing-releasing hormone receptor|luliberin receptor|type I GnRH receptor |
Position | 4q21.2 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.860G>A; p.G287E; 4:67740607-67740607 |
skin | malignant_melanoma | Substitution - Missense |
c.872G>A; p.W291*; 4:67740595-67740595 |
central_nervous_system; brain | glioma | Substitution - Nonsense |
c.222A>G; p.S74S; 4:67754114-67754114 |
liver | carcinoma | Substitution - coding silent |
c.222A>G; p.S74S; 4:67754114-67754114 |
liver | carcinoma | Substitution - coding silent |
c.160G>T; p.A54S; 4:67754176-67754176 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.200A>G; p.K67R; 4:67754136-67754136 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.358C>A; p.L120I; 4:67753978-67753978 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.208G>A; p.G70R; 4:67754128-67754128 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.907C>A; p.P303T; 4:67740560-67740560 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.112C>T; p.R38*; 4:67754224-67754224 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.784C>T; p.R262W; 4:67740683-67740683 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.184_186delAAG; p.K62delK; 4:67754150-67754152 |
lung | carcinoma; adenocarcinoma | Deletion - In frame |
c.642C>A; p.F214L; 4:67744668-67744668 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.416G>A; p.R139H; 4:67753920-67753920 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.252C>T; p.T84T; 4:67754084-67754084 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.658T>C; p.F220L; 4:67744652-67744652 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.476T>C; p.M159T; 4:67753860-67753860 |
oesophagus; upper_third | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.894C>T; p.N298N; 4:67740573-67740573 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; myelofibrosis | Substitution - coding silent |
c.624A>C; p.Q208H; 4:67744686-67744686 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.837C>T; p.C279C; 4:67740630-67740630 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.147T>C; p.S49S; 4:67754189-67754189 |
ovary | other; neoplasm | Substitution - coding silent |
c.147T>C; p.S49S; 4:67754189-67754189 |
ovary | other; neoplasm | Substitution - coding silent |
c.739delC; p.H247fs*5; 4:67744571-67744571 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.660C>A; p.F220L; 4:67744650-67744650 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.515G>T; p.G172V; 4:67753821-67753821 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; mantle_cell_lymphoma | Substitution - Missense |
c.84C>T; p.L28L; 4:67754252-67754252 |
oesophagus | carcinoma | Substitution - coding silent |
c.388T>C; p.F130L; 4:67753948-67753948 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.303G>A; p.W101*; 4:67754033-67754033 |
skin | malignant_melanoma | Substitution - Nonsense |
c.867G>A; p.W289*; 4:67740600-67740600 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Nonsense |
c.867G>A; p.W289*; 4:67740600-67740600 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.930C>A; p.L310L; 4:67740537-67740537 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.340T>C; p.C114R; 4:67753996-67753996 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.855C>T; p.V285V; 4:67740612-67740612 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.415C>A; p.R139S; 4:67753921-67753921 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.866G>A; p.W289*; 4:67740601-67740601 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.326C>T; p.A109V; 4:67754010-67754010 |
liver | carcinoma | Substitution - Missense |
c.326C>T; p.A109V; 4:67754010-67754010 |
liver | carcinoma | Substitution - Missense |
c.428T>A; p.I143N; 4:67753908-67753908 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.579C>A; p.F193L; 4:67744731-67744731 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.415C>T; p.R139C; 4:67753921-67753921 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.415C>T; p.R139C; 4:67753921-67753921 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.126T>C; p.T42T; 4:67754210-67754210 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.126T>C; p.T42T; 4:67754210-67754210 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.124A>T; p.T42S; 4:67754212-67754212 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.431C>T; p.T144M; 4:67753905-67753905 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.605T>C; p.F202S; 4:67744705-67744705 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.263_287del25; p.L88fs*25; 4:67754049-67754073 |
ovary | carcinoma; serous_carcinoma | Deletion - Frameshift |
c.718C>T; p.R240W; 4:67744592-67744592 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.401T>G; p.V134G; 4:67753935-67753935 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.390C>T; p.F130F; 4:67753946-67753946 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.526T>A; p.Y176N; 4:67744784-67744784 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.687C>A; p.I229I; 4:67744623-67744623 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.466G>A; p.G156R; 4:67753870-67753870 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.741C>T; p.H247H; 4:67744569-67744569 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - coding silent |
c.346G>C; p.V116L; 4:67753990-67753990 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.796_797delCT; p.L266fs*27; 4:67740670-67740671 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.946C>T; p.P316S; 4:67740521-67740521 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.296G>A; p.G99E; 4:67754040-67754040 |
skin | malignant_melanoma | Substitution - Missense |
c.808G>A; p.V270I; 4:67740659-67740659 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.498C>A; p.L166L; 4:67753838-67753838 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |