Entrez Gene

Basic Information
Gene ID	2740
Name	GLP1R
Synonymous	glucagon-like peptide 1 receptor;GLP1R;glucagon-like peptide 1 receptor
Definition	GLP-1 receptor\|GLP-1-R\|GLP-1R
Position	6p21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1296C>A; p.S432R; 6:39085977-39085977	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1296C>A; p.S432R; 6:39085977-39085977	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.682C>T; p.L228L; 6:39073628-39073628	skin	malignant_melanoma	Substitution - coding silent
c.610A>C; p.M204L; 6:39072962-39072962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1074C>T; p.P358P; 6:39079594-39079594	skin	malignant_melanoma	Substitution - coding silent
c.609G>C; p.W203C; 6:39072961-39072961	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1305C>G; p.P435P; 6:39085986-39085986	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.921C>T; p.L307L; 6:39078993-39078993	skin	malignant_melanoma	Substitution - coding silent
c.473C>T; p.A158V; 6:39066267-39066267	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1343C>T; p.T448M; 6:39086024-39086024	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.991G>C; p.V331L; 6:39079148-39079148	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.903C>T; p.S301S; 6:39078975-39078975	skin	malignant_melanoma	Substitution - coding silent
c.1283A>G; p.Q428R; 6:39085964-39085964	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.143G>A; p.R48H; 6:39056461-39056461	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.143G>A; p.R48H; 6:39056461-39056461	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.229C>T; p.P77S; 6:39057525-39057525	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.694C>T; p.L232F; 6:39073640-39073640	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1255C>T; p.R419C; 6:39085936-39085936	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1194G>C; p.V398V; 6:39080709-39080709	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.441C>A; p.I147I; 6:39066235-39066235	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3G>T; p.M1I; 6:39048843-39048843	liver	carcinoma	Substitution - Missense
c.300G>A; p.V100V; 6:39065727-39065727	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.391C>T; p.R131*; 6:39065818-39065818	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.131G>A; p.R44H; 6:39056449-39056449	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.104C>T; p.T35M; 6:39056422-39056422	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.158A>T; p.D53V; 6:39056476-39056476	breast	carcinoma	Substitution - Missense
c.1240C>T; p.R414W; 6:39085921-39085921	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1240C>T; p.R414W; 6:39085921-39085921	NS	malignant_melanoma	Substitution - Missense
c.1240C>T; p.R414W; 6:39085921-39085921	NS	malignant_melanoma	Substitution - Missense
c.1240C>T; p.R414W; 6:39085921-39085921	skin	malignant_melanoma	Substitution - Missense
c.423C>G; p.L141L; 6:39066217-39066217	breast	carcinoma	Substitution - coding silent
c.1240C>T; p.R414W; 6:39085921-39085921	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.395G>T; p.G132V; 6:39065822-39065822	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1139G>A; p.R380H; 6:39079659-39079659	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1194G>T; p.V398V; 6:39080709-39080709	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1033A>T; p.I345F; 6:39079190-39079190	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.347C>T; p.S116F; 6:39065774-39065774	liver	carcinoma	Substitution - Missense
c.347C>T; p.S116F; 6:39065774-39065774	skin	malignant_melanoma	Substitution - Missense
c.31G>A; p.A11T; 6:39048871-39048871	kidney	other; neoplasm	Substitution - Missense
c.236C>T; p.S79L; 6:39057532-39057532	skin	malignant_melanoma	Substitution - Missense
c.347C>T; p.S116F; 6:39065774-39065774	liver	carcinoma	Substitution - Missense
c.93C>T; p.S31S; 6:39056411-39056411	skin	malignant_melanoma	Substitution - coding silent
c.1141T>A; p.F381I; 6:39079661-39079661	liver	carcinoma	Substitution - Missense
c.119G>A; p.R40Q; 6:39056437-39056437	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1141T>A; p.F381I; 6:39079661-39079661	liver	carcinoma	Substitution - Missense
c.808G>A; p.V270M; 6:39073754-39073754	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.990C>T; p.I330I; 6:39079147-39079147	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.885C>A; p.G295G; 6:39078957-39078957	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.438C>T; p.I146I; 6:39066232-39066232	skin	malignant_melanoma	Substitution - coding silent
c.1013A>T; p.N338I; 6:39079170-39079170	skin	malignant_melanoma	Substitution - Missense
c.237G>A; p.S79S; 6:39057533-39057533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.92C>T; p.S31F; 6:39056410-39056410	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.322G>A; p.G108S; 6:39065749-39065749	liver	carcinoma	Substitution - Missense
c.502G>A; p.G168S; 6:39066296-39066296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.435C>T; p.Y145Y; 6:39066229-39066229	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1372T>C; p.C458R; 6:39086053-39086053	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.20C>T; p.P7L; 6:39048860-39048860	thyroid	other; neoplasm	Substitution - Missense
c.1154T>G; p.F385C; 6:39079674-39079674	skin	malignant_melanoma	Substitution - Missense
c.1288G>A; p.D430N; 6:39085969-39085969	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.510-1_510GA>AC; p.?; 6:39072861-39072862	cervix	carcinoma; squamous_cell_carcinoma	Unknown
c.856A>G; p.I286V; 6:39078354-39078354	breast	carcinoma	Substitution - Missense
c.969C>T; p.I323I; 6:39079126-39079126	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.969C>T; p.I323I; 6:39079126-39079126	pancreas	NS	Substitution - coding silent
c.364G>A; p.D122N; 6:39065791-39065791	skin	malignant_melanoma	Substitution - Missense
c.976C>T; p.R326W; 6:39079133-39079133	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>A; p.A209T; 6:39072977-39072977	prostate	carcinoma	Substitution - Missense
c.1272C>T; p.H424H; 6:39085953-39085953	skin	malignant_melanoma	Substitution - coding silent
c.1270C>G; p.H424D; 6:39085951-39085951	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.392G>A; p.R131Q; 6:39065819-39065819	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.981C>A; p.V327V; 6:39079138-39079138	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.392G>A; p.R131Q; 6:39065819-39065819	urinary_tract; bladder	carcinoma	Substitution - Missense
c.392G>A; p.R131Q; 6:39065819-39065819	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1196C>A; p.A399D; 6:39080711-39080711	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.133C>T; p.Q45*; 6:39056451-39056451	skin	malignant_melanoma	Substitution - Nonsense
c.614A>G; p.Y205C; 6:39072966-39072966	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.614A>G; p.Y205C; 6:39072966-39072966	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1122C>T; p.H374H; 6:39079642-39079642	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1175C>T; p.S392F; 6:39079695-39079695	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1175C>T; p.S392F; 6:39079695-39079695	skin	malignant_melanoma	Substitution - Missense
c.1175C>T; p.S392F; 6:39079695-39079695	skin	malignant_melanoma	Substitution - Missense
c.646G>A; p.G216R; 6:39072998-39072998	skin	malignant_melanoma	Substitution - Missense
c.646G>A; p.G216R; 6:39072998-39072998	skin	malignant_melanoma	Substitution - Missense
c.656C>T; p.S219F; 6:39073008-39073008	skin	malignant_melanoma	Substitution - Missense
c.79-2A>C; p.?; 6:39056395-39056395	skin	malignant_melanoma	Unknown
c.142C>T; p.R48C; 6:39056460-39056460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.564C>G; p.I188M; 6:39072916-39072916	urinary_tract; bladder	carcinoma	Substitution - Missense
c.885-1G>A; p.?; 6:39078956-39078956	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1383C>A; p.S461S; 6:39086064-39086064	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.359G>A; p.W120*; 6:39065786-39065786	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.934C>T; p.P312S; 6:39079006-39079006	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.679C>T; p.R227C; 6:39073625-39073625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1090G>T; p.E364*; 6:39079610-39079610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.203A>G; p.E68G; 6:39057499-39057499	breast	carcinoma	Substitution - Missense
c.643G>A; p.D215N; 6:39072995-39072995	skin	malignant_melanoma	Substitution - Missense
c.407C>T; p.S136F; 6:39066201-39066201	skin	malignant_melanoma	Substitution - Missense
c.592G>T; p.D198Y; 6:39072944-39072944	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.496C>T; p.L166F; 6:39066290-39066290	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.483C>T; p.I161I; 6:39066277-39066277	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.483C>T; p.I161I; 6:39066277-39066277	skin	malignant_melanoma	Substitution - coding silent
c.973G>C; p.V325L; 6:39079130-39079130	breast	carcinoma	Substitution - Missense
c.528G>A; p.R176R; 6:39072880-39072880	skin	malignant_melanoma	Substitution - coding silent
c.1113G>A; p.M371I; 6:39079633-39079633	skin	malignant_melanoma	Substitution - Missense
c.580G>A; p.V194I; 6:39072932-39072932	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	Substitution - Missense
c.580G>A; p.V194I; 6:39072932-39072932	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.118C>T; p.R40*; 6:39056436-39056436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.118C>T; p.R40*; 6:39056436-39056436	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.118C>T; p.R40*; 6:39056436-39056436	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.118C>T; p.R40*; 6:39056436-39056436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.444C>A; p.Y148*; 6:39066238-39066238	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1329G>A; p.L443L; 6:39086010-39086010	skin	malignant_melanoma	Substitution - coding silent
c.183C>T; p.F61F; 6:39057479-39057479	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015C>A; p.L339I; 6:39079172-39079172	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.622G>A; p.A208T; 6:39072974-39072974	skin	malignant_melanoma	Substitution - Missense
c.1068C>A; p.L356L; 6:39079588-39079588	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.390G>A; p.K130K; 6:39065817-39065817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.441C>T; p.I147I; 6:39066235-39066235	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.744C>T; p.G248G; 6:39073690-39073690	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.744C>T; p.G248G; 6:39073690-39073690	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.411G>A; p.P137P; 6:39066205-39066205	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.411G>A; p.P137P; 6:39066205-39066205	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.819C>A; p.G273G; 6:39073765-39073765	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1071C>A; p.I357I; 6:39079591-39079591	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1071C>A; p.I357I; 6:39079591-39079591	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.399A>G; p.E133E; 6:39065826-39065826	thyroid	other; neoplasm	Substitution - coding silent
c.573A>T; p.A191A; 6:39072925-39072925	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.573A>T; p.A191A; 6:39072925-39072925	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.258C>G; p.P86P; 6:39057554-39057554	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.957G>A; p.V319V; 6:39079114-39079114	breast	carcinoma	Substitution - coding silent
c.475C>A; p.L159M; 6:39066269-39066269	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.526A>C; p.R176R; 6:39072878-39072878	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.526A>C; p.R176R; 6:39072878-39072878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.526A>C; p.R176R; 6:39072878-39072878	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1059G>A; p.T353T; 6:39079579-39079579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.130C>T; p.R44C; 6:39056448-39056448	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.830C>T; p.P277L; 6:39078328-39078328	skin; ankle	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.423C>T; p.L141L; 6:39066217-39066217	pancreas	carcinoma	Substitution - coding silent
c.423C>T; p.L141L; 6:39066217-39066217	pancreas	carcinoma	Substitution - coding silent
c.394G>T; p.G132W; 6:39065821-39065821	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.457G>A; p.A153T; 6:39066251-39066251	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1242G>T; p.R414R; 6:39085923-39085923	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.963C>T; p.F321F; 6:39079120-39079120	skin	malignant_melanoma	Substitution - coding silent
c.456C>T; p.Y152Y; 6:39066250-39066250	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.456C>T; p.Y152Y; 6:39066250-39066250	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.287C>T; p.P96L; 6:39065714-39065714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.462C>G; p.L154L; 6:39066256-39066256	breast	carcinoma	Substitution - coding silent
c.287C>T; p.P96L; 6:39065714-39065714	large_intestine; rectum	NS	Substitution - Missense

COSMIC somatic mutation [Top]