Entrez Gene

Basic Information
Gene ID	27074
Name	LAMP3
Synonymous	lysosomal-associated membrane protein 3;LAMP3;lysosomal-associated membrane protein 3
Definition	DC-lysosome-associated membrane glycoprotein\|lysosome-associated membrane glycoprotein 3
Position	3q26.3-q27
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.812C>T; p.S271F; 3:183152451-183152451	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1225C>G; p.Q409E; 3:183124107-183124107	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.901T>C; p.Y301H; 3:183140583-183140583	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.961G>A; p.G321R; 3:183135873-183135873	skin	malignant_melanoma	Substitution - Missense
c.214C>T; p.H72Y; 3:183154227-183154227	skin	malignant_melanoma	Substitution - Missense
c.711T>C; p.C237C; 3:183153730-183153730	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.861C>T; p.G287G; 3:183152402-183152402	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.899C>T; p.S300L; 3:183140585-183140585	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.454G>A; p.V152I; 3:183153987-183153987	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.139G>A; p.D47N; 3:183154302-183154302	skin	malignant_melanoma	Substitution - Missense
c.761T>G; p.V254G; 3:183152502-183152502	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.326C>A; p.A109D; 3:183154115-183154115	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.803C>T; p.T268M; 3:183152460-183152460	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.803C>T; p.T268M; 3:183152460-183152460	pancreas	carcinoma	Substitution - Missense
c.114A>G; p.Q38Q; 3:183154327-183154327	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.803C>T; p.T268M; 3:183152460-183152460	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.518C>T; p.S173L; 3:183153923-183153923	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.112C>T; p.Q38*; 3:183154329-183154329	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.431C>G; p.T144R; 3:183154010-183154010	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.638G>A; p.G213E; 3:183153803-183153803	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.629C>T; p.T210M; 3:183153812-183153812	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1212C>T; p.I404I; 3:183124120-183124120	skin	malignant_melanoma	Substitution - coding silent
c.477C>T; p.T159T; 3:183153964-183153964	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.754G>A; p.E252K; 3:183153687-183153687	skin	malignant_melanoma	Substitution - Missense
c.234G>A; p.A78A; 3:183154207-183154207	prostate	carcinoma	Substitution - coding silent
c.403C>T; p.P135S; 3:183154038-183154038	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.619C>T; p.P207S; 3:183153822-183153822	pancreas	carcinoma	Substitution - Missense
c.990G>T; p.Q330H; 3:183135844-183135844	liver	carcinoma	Substitution - Missense
c.990G>T; p.Q330H; 3:183135844-183135844	liver	carcinoma	Substitution - Missense
c.60C>T; p.H20H; 3:183154381-183154381	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.816G>A; p.G272G; 3:183152447-183152447	skin	malignant_melanoma	Substitution - coding silent
c.475A>C; p.T159P; 3:183153966-183153966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.816G>A; p.G272G; 3:183152447-183152447	skin	malignant_melanoma	Substitution - coding silent
c.127G>A; p.A43T; 3:183154314-183154314	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1170C>A; p.I390I; 3:183124162-183124162	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1081C>G; p.Q361E; 3:183135753-183135753	urinary_tract; bladder	carcinoma	Substitution - Missense
c.721G>C; p.E241Q; 3:183153720-183153720	breast	carcinoma	Substitution - Missense
c.843T>C; p.L281L; 3:183152420-183152420	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.519G>A; p.S173S; 3:183153922-183153922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.662C>T; p.S221L; 3:183153779-183153779	skin	malignant_melanoma	Substitution - Missense
c.543C>T; p.T181T; 3:183153898-183153898	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1111G>A; p.G371R; 3:183135723-183135723	skin	malignant_melanoma	Substitution - Missense
c.642C>A; p.P214P; 3:183153799-183153799	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1244G>T; p.R415I; 3:183124088-183124088	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.446C>A; p.S149*; 3:183153995-183153995	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.446C>A; p.S149*; 3:183153995-183153995	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1116T>C; p.N372N; 3:183135718-183135718	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.170A>G; p.K57R; 3:183154271-183154271	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.611C>T; p.T204I; 3:183153830-183153830	skin	malignant_melanoma	Substitution - Missense
c.92C>T; p.P31L; 3:183154349-183154349	skin	malignant_melanoma	Substitution - Missense
c.738G>A; p.L246L; 3:183153703-183153703	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.856C>T; p.Q286*; 3:183152407-183152407	skin	malignant_melanoma	Substitution - Nonsense
c.1017C>T; p.C339C; 3:183135817-183135817	prostate	carcinoma	Substitution - coding silent
c.1017C>T; p.C339C; 3:183135817-183135817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.255A>G; p.T85T; 3:183154186-183154186	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.107A>G; p.Y36C; 3:183154334-183154334	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.892G>A; p.E298K; 3:183140592-183140592	skin	malignant_melanoma	Substitution - Missense
c.1209A>G; p.K403K; 3:183124123-183124123	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.584C>T; p.T195M; 3:183153857-183153857	breast	carcinoma	Substitution - Missense
c.738G>T; p.L246L; 3:183153703-183153703	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.696C>T; p.N232N; 3:183153745-183153745	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.275A>T; p.K92I; 3:183154166-183154166	skin	malignant_melanoma	Substitution - Missense
c.1062A>C; p.K354N; 3:183135772-183135772	skin	malignant_melanoma	Substitution - Missense
c.672G>C; p.K224N; 3:183153769-183153769	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.804G>A; p.T268T; 3:183152459-183152459	pancreas	carcinoma	Substitution - coding silent
c.426T>G; p.A142A; 3:183154015-183154015	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.952A>G; p.I318V; 3:183135882-183135882	thyroid	other; neoplasm	Substitution - Missense
c.758C>T; p.S253L; 3:183153683-183153683	skin	malignant_melanoma	Substitution - Missense
c.1131G>C; p.S377S; 3:183124201-183124201	ovary	other; neoplasm	Substitution - coding silent
c.835T>C; p.S279P; 3:183152428-183152428	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.143T>C; p.I48T; 3:183154298-183154298	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.143T>C; p.I48T; 3:183154298-183154298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.143T>C; p.I48T; 3:183154298-183154298	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.150delA; p.K50fs*15; 3:183154291-183154291	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.990G>A; p.Q330Q; 3:183135844-183135844	skin	malignant_melanoma	Substitution - coding silent
c.764T>C; p.F255S; 3:183152499-183152499	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.614C>T; p.A205V; 3:183153827-183153827	thyroid	carcinoma	Substitution - Missense
c.1099G>A; p.D367N; 3:183135735-183135735	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.398C>T; p.S133L; 3:183154043-183154043	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1112G>A; p.G371E; 3:183135722-183135722	skin	malignant_melanoma	Substitution - Missense
c.398C>T; p.S133L; 3:183154043-183154043	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1068C>T; p.T356T; 3:183135766-183135766	thyroid	other; neoplasm	Substitution - coding silent
c.829C>T; p.R277*; 3:183152434-183152434	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.975G>A; p.A325A; 3:183135859-183135859	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.314T>G; p.V105G; 3:183154127-183154127	skin	malignant_melanoma	Substitution - Missense
c.910A>G; p.S304G; 3:183140574-183140574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.278A>G; p.N93S; 3:183154163-183154163	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.618A>C; p.A206A; 3:183153823-183153823	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.559C>G; p.Q187E; 3:183153882-183153882	pancreas	carcinoma	Substitution - Missense
c.618A>C; p.A206A; 3:183153823-183153823	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.618A>C; p.A206A; 3:183153823-183153823	thyroid	other; neoplasm	Substitution - coding silent
c.839A>T; p.N280I; 3:183152424-183152424	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.420A>C; p.P140P; 3:183154021-183154021	breast	carcinoma	Substitution - coding silent
c.688G>A; p.V230I; 3:183153753-183153753	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1160_1161insG; p.I387fs*17; 3:183124171-183124172	breast	carcinoma	Insertion - Frameshift
c.577G>T; p.G193*; 3:183153864-183153864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.767C>T; p.S256L; 3:183152496-183152496	skin	malignant_melanoma	Substitution - Missense
c.469G>A; p.G157R; 3:183153972-183153972	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1219A>T; p.R407W; 3:183124113-183124113	thyroid	carcinoma	Substitution - Missense
c.150_151insA; p.P51fs*7; 3:183154290-183154291	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.476C>A; p.T159N; 3:183153965-183153965	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1191G>T; p.M397I; 3:183124141-183124141	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.256A>G; p.T86A; 3:183154185-183154185	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1069G>A; p.D357N; 3:183135765-183135765	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1069G>A; p.D357N; 3:183135765-183135765	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.760-1G>C; p.?; 3:183152504-183152504	ovary	carcinoma; serous_carcinoma	Unknown
c.772C>T; p.R258W; 3:183152491-183152491	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.772C>T; p.R258W; 3:183152491-183152491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.267G>A; p.A89A; 3:183154174-183154174	thyroid	other; neoplasm	Substitution - coding silent

COSMIC somatic mutation [Top]