Entrez Gene

Basic Information
Gene ID	23076
Name	RRP1B
Synonymous	ribosomal RNA processing 1B;RRP1B;ribosomal RNA processing 1B
Definition	RRP1-like protein B\|protein phosphatase 1, regulatory subunit 136\|ribosomal RNA processing 1 homolog B\|ribosomal RNA processing protein 1 homolog B
Position	21q22.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.864C>A; p.T288T; 21:43683346-43683346	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.855C>T; p.D285D; 21:43683337-43683337	skin; shoulder	malignant_melanoma	Substitution - coding silent
c.868G>A; p.E290K; 21:43683350-43683350	skin	malignant_melanoma	Substitution - Missense
c.408C>T; p.G136G; 21:43674686-43674686	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1263A>G; p.P421P; 21:43687637-43687637	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.561T>C; p.D187D; 21:43676283-43676283	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2196A>C; p.S732S; 21:43693302-43693302	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.613G>T; p.D205Y; 21:43676335-43676335	urinary_tract; bladder	carcinoma	Substitution - Missense
c.476A>G; p.Q159R; 21:43675090-43675090	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1114G>A; p.E372K; 21:43686908-43686908	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2152G>A; p.E718K; 21:43693258-43693258	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2152G>A; p.E718K; 21:43693258-43693258	urinary_tract; bladder	carcinoma	Substitution - Missense
c.661G>A; p.V221I; 21:43676779-43676779	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.269C>T; p.A90V; 21:43672363-43672363	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.12C>T; p.A4A; 21:43659676-43659676	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1841_1842CC>AT; p.S614Y; 21:43688215-43688216	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1619C>T; p.P540L; 21:43687993-43687993	liver	carcinoma	Substitution - Missense
c.1619C>T; p.P540L; 21:43687993-43687993	skin	malignant_melanoma	Substitution - Missense
c.1619C>T; p.P540L; 21:43687993-43687993	liver	carcinoma	Substitution - Missense
c.1251G>A; p.G417G; 21:43687625-43687625	skin	malignant_melanoma	Substitution - coding silent
c.2171G>A; p.G724E; 21:43693277-43693277	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1847C>T; p.A616V; 21:43688221-43688221	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.504C>T; p.F168F; 21:43675118-43675118	skin	malignant_melanoma	Substitution - coding silent
c.1592C>A; p.P531H; 21:43687966-43687966	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1369G>T; p.E457*; 21:43687743-43687743	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1594G>A; p.V532I; 21:43687968-43687968	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1342G>A; p.A448T; 21:43687716-43687716	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1242A>T; p.P414P; 21:43687616-43687616	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1629T>G; p.P543P; 21:43688003-43688003	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1201A>C; p.R401R; 21:43687575-43687575	skin	malignant_melanoma	Substitution - coding silent
c.954C>T; p.H318H; 21:43684615-43684615	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1427G>A; p.R476Q; 21:43687801-43687801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1168G>A; p.E390K; 21:43687542-43687542	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.220C>A; p.L74I; 21:43672314-43672314	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.685G>A; p.E229K; 21:43676803-43676803	urinary_tract; bladder	carcinoma	Substitution - Missense
c.538delG; p.K182fs*4; 21:43675152-43675152	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.751G>C; p.E251Q; 21:43676869-43676869	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1030A>G; p.S344G; 21:43686824-43686824	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.603G>A; p.A201A; 21:43676325-43676325	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2124G>C; p.T708T; 21:43693230-43693230	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.603G>A; p.A201A; 21:43676325-43676325	breast	carcinoma	Substitution - coding silent
c.2050G>T; p.V684F; 21:43691469-43691469	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1054G>T; p.D352Y; 21:43686848-43686848	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1152C>A; p.V384V; 21:43687526-43687526	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.436T>G; p.L146V; 21:43675050-43675050	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.447G>T; p.L149L; 21:43675061-43675061	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.384C>T; p.S128S; 21:43674662-43674662	skin	malignant_melanoma	Substitution - coding silent
c.240G>T; p.Q80H; 21:43672334-43672334	pancreas	carcinoma	Substitution - Missense
c.684T>C; p.P228P; 21:43676802-43676802	prostate	carcinoma	Substitution - coding silent
c.684T>C; p.P228P; 21:43676802-43676802	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1186C>T; p.L396F; 21:43687560-43687560	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1186C>T; p.L396F; 21:43687560-43687560	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.240G>T; p.Q80H; 21:43672334-43672334	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1308G>A; p.L436L; 21:43687682-43687682	prostate	carcinoma	Substitution - coding silent
c.692C>T; p.T231M; 21:43676810-43676810	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.692C>T; p.T231M; 21:43676810-43676810	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.734C>T; p.S245F; 21:43676852-43676852	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.734C>T; p.S245F; 21:43676852-43676852	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1651C>T; p.P551S; 21:43688025-43688025	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1189C>T; p.Q397*; 21:43687563-43687563	skin	malignant_melanoma	Substitution - Nonsense
c.388G>C; p.E130Q; 21:43674666-43674666	oesophagus	carcinoma	Substitution - Missense
c.809A>G; p.N270S; 21:43683291-43683291	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2216_2217TG>AA; p.V739E; 21:43693322-43693323	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.651C>T; p.F217F; 21:43676769-43676769	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1934T>C; p.F645S; 21:43690355-43690355	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>C; p.E157Q; 21:43675083-43675083	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2135G>A; p.R712Q; 21:43693241-43693241	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2078C>A; p.T693N; 21:43691497-43691497	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.648C>A; p.V216V; 21:43676766-43676766	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1732G>A; p.G578S; 21:43688106-43688106	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1668G>A; p.E556E; 21:43688042-43688042	skin	malignant_melanoma	Substitution - coding silent
c.710C>T; p.T237I; 21:43676828-43676828	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.174C>T; p.L58L; 21:43669927-43669927	skin	malignant_melanoma	Substitution - coding silent
c.968G>A; p.R323H; 21:43684629-43684629	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1203_1205delGAA; p.K406delK; 21:43687577-43687579	pancreas	carcinoma; acinar_carcinoma	Deletion - In frame
c.498C>T; p.F166F; 21:43675112-43675112	skin	malignant_melanoma	Substitution - coding silent
c.1426C>T; p.R476W; 21:43687800-43687800	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1018A>G; p.I340V; 21:43686812-43686812	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.401G>A; p.R134Q; 21:43674679-43674679	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1700G>A; p.R567H; 21:43688074-43688074	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1700G>A; p.R567H; 21:43688074-43688074	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.579C>T; p.I193I; 21:43676301-43676301	skin	malignant_melanoma	Substitution - coding silent
c.542G>T; p.G181V; 21:43675156-43675156	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1445C>T; p.A482V; 21:43687819-43687819	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1695C>G; p.P565P; 21:43688069-43688069	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.705G>A; p.Q235Q; 21:43676823-43676823	prostate	carcinoma	Substitution - coding silent
c.916C>T; p.R306*; 21:43684577-43684577	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.313G>A; p.E105K; 21:43673911-43673911	urinary_tract; bladder	carcinoma	Substitution - Missense
c.42G>A; p.Q14Q; 21:43659706-43659706	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1622C>T; p.A541V; 21:43687996-43687996	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1262C>T; p.P421L; 21:43687636-43687636	skin; trunk	malignant_melanoma	Substitution - Missense
c.1670G>A; p.G557E; 21:43688044-43688044	skin	malignant_melanoma	Substitution - Missense
c.593A>G; p.K198R; 21:43676315-43676315	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Missense
c.688G>C; p.E230Q; 21:43676806-43676806	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2123C>T; p.T708M; 21:43693229-43693229	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.556G>C; p.A186P; 21:43676278-43676278	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.661G>C; p.V221L; 21:43676779-43676779	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1037C>T; p.A346V; 21:43686831-43686831	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.364C>T; p.R122C; 21:43674642-43674642	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1662C>T; p.P554P; 21:43688036-43688036	stomach	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]