Entrez Gene

Basic Information
Gene ID	1901
Name	S1PR1
Synonymous	sphingosine-1-phosphate receptor 1;S1PR1;sphingosine-1-phosphate receptor 1
Definition	S1P receptor 1\|S1P receptor Edg-1\|endothelial differentiation G-protein coupled receptor 1\|endothelial differentiation, sphingolipid G-protein-coupled receptor, 1\|sphingosine 1-phosphate receptor 1\|sphingosine 1-phosphate receptor EDG1\|sphingosine 1-phosp
Position	1p21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.117G>A; p.A39A; 1:101239101-101239101	breast	carcinoma	Substitution - coding silent
c.757G>T; p.A253S; 1:101239741-101239741	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.255C>A; p.G85G; 1:101239239-101239239	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.791T>C; p.V264A; 1:101239775-101239775	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.392C>A; p.S131Y; 1:101239376-101239376	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.535A>G; p.I179V; 1:101239519-101239519	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.394G>A; p.V132M; 1:101239378-101239378	urinary_tract; bladder	carcinoma	Substitution - Missense
c.394G>A; p.V132M; 1:101239378-101239378	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1082C>G; p.P361R; 1:101240066-101240066	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.693G>A; p.R231R; 1:101239677-101239677	skin; leg	malignant_melanoma	Substitution - coding silent
c.693G>A; p.R231R; 1:101239677-101239677	skin; leg	malignant_melanoma	Substitution - coding silent
c.1020C>G; p.F340L; 1:101240004-101240004	NS	NS	Substitution - Missense
c.772G>A; p.V258I; 1:101239756-101239756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.651C>T; p.I217I; 1:101239635-101239635	pancreas	carcinoma	Substitution - coding silent
c.1149delG; p.*383fs?; 1:101240133-101240133	eye; uveal_tract	malignant_melanoma; spindle	Deletion - Frameshift
c.441G>A; p.L147L; 1:101239425-101239425	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.490A>G; p.I164V; 1:101239474-101239474	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.648C>G; p.S216S; 1:101239632-101239632	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.697C>T; p.R233C; 1:101239681-101239681	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.675C>A; p.Y225*; 1:101239659-101239659	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.681G>T; p.L227F; 1:101239665-101239665	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.995C>T; p.P332L; 1:101239979-101239979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.755T>C; p.L252P; 1:101239739-101239739	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.894G>A; p.V298V; 1:101239878-101239878	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.217A>C; p.T73P; 1:101239201-101239201	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.960G>A; p.R320R; 1:101239944-101239944	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1148A>C; p.*383S; 1:101240132-101240132	large_intestine	carcinoma; adenocarcinoma	Nonstop extension
c.57C>G; p.Y19*; 1:101239041-101239041	autonomic_ganglia	neuroblastoma	Substitution - Nonsense
c.951G>T; p.E317D; 1:101239935-101239935	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.512C>G; p.S171C; 1:101239496-101239496	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.798C>T; p.I266I; 1:101239782-101239782	skin	malignant_melanoma	Substitution - coding silent
c.197T>C; p.V66A; 1:101239181-101239181	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.147G>A; p.S49S; 1:101239131-101239131	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1145C>T; p.S382F; 1:101240129-101240129	skin	malignant_melanoma	Substitution - Missense
c.1145C>T; p.S382F; 1:101240129-101240129	skin	malignant_melanoma	Substitution - Missense
c.943A>G; p.N315D; 1:101239927-101239927	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.819C>T; p.F273F; 1:101239803-101239803	pancreas	carcinoma	Substitution - coding silent
c.959G>A; p.R320Q; 1:101239943-101239943	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.959G>A; p.R320Q; 1:101239943-101239943	NS	NS	Substitution - Missense
c.758C>T; p.A253V; 1:101239742-101239742	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1055G>T; p.R352L; 1:101240039-101240039	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1092C>T; p.D364D; 1:101240076-101240076	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.580G>A; p.V194M; 1:101239564-101239564	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.580G>A; p.V194M; 1:101239564-101239564	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993C>T; p.C331C; 1:101239977-101239977	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.993C>T; p.C331C; 1:101239977-101239977	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.993C>T; p.C331C; 1:101239977-101239977	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1066G>T; p.D356Y; 1:101240050-101240050	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1066G>T; p.D356Y; 1:101240050-101240050	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.879G>A; p.A293A; 1:101239863-101239863	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.688A>G; p.T230A; 1:101239672-101239672	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.780C>T; p.I260I; 1:101239764-101239764	skin	malignant_melanoma	Substitution - coding silent
c.343_344GC>TT; p.A115>?; 1:101239327-101239328	lung	carcinoma; adenocarcinoma	Complex
c.238A>T; p.M80L; 1:101239222-101239222	skin	malignant_melanoma	Substitution - Missense
c.780C>T; p.I260I; 1:101239764-101239764	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.780C>T; p.I260I; 1:101239764-101239764	skin	malignant_melanoma	Substitution - coding silent
c.977T>C; p.M326T; 1:101239961-101239961	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.591C>A; p.L197L; 1:101239575-101239575	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.977T>C; p.M326T; 1:101239961-101239961	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1035C>T; p.I345I; 1:101240019-101240019	central_nervous_system; brain	glioma	Substitution - coding silent
c.423G>T; p.E141D; 1:101239407-101239407	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1038C>T; p.A346A; 1:101240022-101240022	skin	malignant_melanoma	Substitution - coding silent
c.1003G>T; p.D335Y; 1:101239987-101239987	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.192C>G; p.I64M; 1:101239176-101239176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1040G>T; p.G347V; 1:101240024-101240024	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.882G>A; p.E294E; 1:101239866-101239866	skin	malignant_melanoma	Substitution - coding silent
c.157A>T; p.I53F; 1:101239141-101239141	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1064C>T; p.S355L; 1:101240048-101240048	skin	malignant_melanoma	Substitution - Missense
c.241T>C; p.Y81H; 1:101239225-101239225	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.241T>C; p.Y81H; 1:101239225-101239225	large_intestine; colon	carcinoma	Substitution - Missense
c.1064C>T; p.S355L; 1:101240048-101240048	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1039G>A; p.G347S; 1:101240023-101240023	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.123G>C; p.K41N; 1:101239107-101239107	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.790G>A; p.V264I; 1:101239774-101239774	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.790G>A; p.V264I; 1:101239774-101239774	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.425G>T; p.R142L; 1:101239409-101239409	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.430A>G; p.I144V; 1:101239414-101239414	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.132C>A; p.S44R; 1:101239116-101239116	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.487C>G; p.L163V; 1:101239471-101239471	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.137A>G; p.K46R; 1:101239121-101239121	liver	carcinoma	Substitution - Missense
c.462G>A; p.G154G; 1:101239446-101239446	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.137A>G; p.K46R; 1:101239121-101239121	liver	carcinoma	Substitution - Missense
c.1149G>T; p.*383Y; 1:101240133-101240133	endometrium	carcinoma; endometrioid_carcinoma	Nonstop extension
c.588G>A; p.P196P; 1:101239572-101239572	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.911C>T; p.S304F; 1:101239895-101239895	thyroid	carcinoma	Substitution - Missense
c.785T>C; p.L262P; 1:101239769-101239769	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.15C>A; p.S5R; 1:101238999-101238999	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.677C>T; p.S226F; 1:101239661-101239661	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.312G>T; p.L104F; 1:101239296-101239296	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1108G>C; p.E370Q; 1:101240092-101240092	liver	carcinoma	Substitution - Missense
c.312G>T; p.L104F; 1:101239296-101239296	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1108G>C; p.E370Q; 1:101240092-101240092	liver	carcinoma	Substitution - Missense
c.823C>G; p.L275V; 1:101239807-101239807	urinary_tract; bladder	carcinoma	Substitution - Missense
c.855G>C; p.K285N; 1:101239839-101239839	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.260T>A; p.L87Q; 1:101239244-101239244	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.408C>T; p.L136L; 1:101239392-101239392	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.752C>T; p.S251L; 1:101239736-101239736	skin	malignant_melanoma	Substitution - Missense
c.624G>A; p.T208T; 1:101239608-101239608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.813G>A; p.P271P; 1:101239797-101239797	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.668G>A; p.R223K; 1:101239652-101239652	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.431T>A; p.I144N; 1:101239415-101239415	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.348_375del28; p.F118fs*21; 1:101239332-101239359	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1076C>T; p.S359F; 1:101240060-101240060	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.955C>T; p.R319C; 1:101239939-101239939	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.317G>T; p.G106V; 1:101239301-101239301	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.835G>T; p.D279Y; 1:101239819-101239819	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.296C>A; p.T99K; 1:101239280-101239280	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.368_369insATA; p.S123>RY; 1:101239352-101239353	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Complex - insertion inframe
c.610C>A; p.L204I; 1:101239594-101239594	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.156_157CA>AT; p.F52>?; 1:101239140-101239141	urinary_tract; bladder	carcinoma	Complex
c.130A>G; p.S44G; 1:101239114-101239114	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.130A>G; p.S44G; 1:101239114-101239114	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.958C>T; p.R320W; 1:101239942-101239942	breast	carcinoma	Substitution - Missense
c.105G>A; p.L35L; 1:101239089-101239089	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1045G>C; p.E349Q; 1:101240029-101240029	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.771C>T; p.T257T; 1:101239755-101239755	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1132G>A; p.V378I; 1:101240116-101240116	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.532C>T; p.P178S; 1:101239516-101239516	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.148G>T; p.V50L; 1:101239132-101239132	breast	carcinoma	Substitution - Missense
c.1098G>A; p.G366G; 1:101240082-101240082	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.737G>A; p.R246H; 1:101239721-101239721	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.737G>A; p.R246H; 1:101239721-101239721	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1093G>A; p.E365K; 1:101240077-101240077	skin	malignant_melanoma	Substitution - Missense
c.768G>T; p.K256N; 1:101239752-101239752	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.878C>T; p.A293V; 1:101239862-101239862	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.878C>T; p.A293V; 1:101239862-101239862	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.878C>T; p.A293V; 1:101239862-101239862	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1023G>A; p.K341K; 1:101240007-101240007	breast	carcinoma	Substitution - coding silent
c.424C>T; p.R142C; 1:101239408-101239408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.154T>C; p.F52L; 1:101239138-101239138	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.424C>T; p.R142C; 1:101239408-101239408	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.213G>C; p.W71C; 1:101239197-101239197	pancreas	carcinoma	Substitution - Missense
c.846C>T; p.C282C; 1:101239830-101239830	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.398T>A; p.F133Y; 1:101239382-101239382	pancreas	carcinoma	Substitution - Missense
c.319G>A; p.A107T; 1:101239303-101239303	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1099G>A; p.D367N; 1:101240083-101240083	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.668G>T; p.R223I; 1:101239652-101239652	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.156C>A; p.F52L; 1:101239140-101239140	urinary_tract; bladder	carcinoma	Substitution - Missense
c.575C>G; p.S192C; 1:101239559-101239559	urinary_tract; bladder	carcinoma	Substitution - Missense
c.652G>T; p.V218F; 1:101239636-101239636	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.759G>A; p.A253A; 1:101239743-101239743	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.759G>A; p.A253A; 1:101239743-101239743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.602A>C; p.H201P; 1:101239586-101239586	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.205A>G; p.T69A; 1:101239189-101239189	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.115G>A; p.A39T; 1:101239099-101239099	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.115G>A; p.A39T; 1:101239099-101239099	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>A; p.I59I; 1:101239161-101239161	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.799G>A; p.A267T; 1:101239783-101239783	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>A; p.A267T; 1:101239783-101239783	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.873C>T; p.F291F; 1:101239857-101239857	skin	malignant_melanoma	Substitution - coding silent
c.873C>T; p.F291F; 1:101239857-101239857	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.153G>C; p.V51V; 1:101239137-101239137	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.328T>C; p.Y110H; 1:101239312-101239312	skin	malignant_melanoma	Substitution - Missense
c.162C>T; p.L54L; 1:101239146-101239146	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]