Entrez Gene

Basic Information
Gene ID	1893
Name	ECM1
Synonymous	extracellular matrix protein 1;ECM1;extracellular matrix protein 1
Definition	secretory component p85
Position	1q21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.493G>C; p.D165H; 1:150510983-150510983	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.470A>T; p.Q157L; 1:150510960-150510960	kidney	other; neoplasm	Substitution - Missense
c.1077G>T; p.W359C; 1:150511825-150511825	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.24C>A; p.A8A; 1:150508233-150508233	liver	carcinoma	Substitution - coding silent
c.266A>G; p.E89G; 1:150509964-150509964	central_nervous_system; brain	glioma	Substitution - Missense
c.952T>G; p.F318V; 1:150511700-150511700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.381G>A; p.K127K; 1:150510178-150510178	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.572G>T; p.G191V; 1:150511062-150511062	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.967C>T; p.R323C; 1:150511715-150511715	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.177C>T; p.H59H; 1:150509716-150509716	skin	malignant_melanoma	Substitution - coding silent
c.553C>T; p.R185C; 1:150511043-150511043	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.553C>T; p.R185C; 1:150511043-150511043	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1517A>T; p.N506I; 1:150513361-150513361	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.531G>A; p.L177L; 1:150511021-150511021	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.591G>A; p.Q197Q; 1:150511081-150511081	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1014G>A; p.L338L; 1:150511762-150511762	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1574C>T; p.S525L; 1:150513418-150513418	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1574C>T; p.S525L; 1:150513418-150513418	urinary_tract; bladder	carcinoma	Substitution - Missense
c.552C>G; p.N184K; 1:150511042-150511042	liver	carcinoma	Substitution - Missense
c.1347C>T; p.C449C; 1:150512767-150512767	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.552C>G; p.N184K; 1:150511042-150511042	liver	carcinoma	Substitution - Missense
c.1442G>A; p.R481Q; 1:150513286-150513286	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1580G>C; p.G527A; 1:150513424-150513424	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1045T>C; p.C349R; 1:150511793-150511793	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1344C>T; p.R448R; 1:150512764-150512764	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1045T>C; p.C349R; 1:150511793-150511793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.732C>A; p.F244L; 1:150511480-150511480	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.640G>T; p.E214*; 1:150511130-150511130	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.954C>T; p.F318F; 1:150511702-150511702	breast	carcinoma	Substitution - coding silent
c.389C>T; p.T130M; 1:150510879-150510879	breast	carcinoma	Substitution - Missense
c.954C>T; p.F318F; 1:150511702-150511702	skin	malignant_melanoma	Substitution - coding silent
c.501delC; p.P169fs*9; 1:150510991-150510991	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1143C>T; p.H381H; 1:150512411-150512411	skin	malignant_melanoma	Substitution - coding silent
c.875C>T; p.S292F; 1:150511623-150511623	skin	malignant_melanoma	Substitution - Missense
c.1323G>C; p.L441L; 1:150512743-150512743	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.614G>A; p.R205H; 1:150511104-150511104	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1488C>A; p.V496V; 1:150513332-150513332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1375T>C; p.C459R; 1:150512795-150512795	breast	carcinoma	Substitution - Missense
c.203C>T; p.P68L; 1:150509742-150509742	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.203C>T; p.P68L; 1:150509742-150509742	skin	malignant_melanoma	Substitution - Missense
c.439G>T; p.A147S; 1:150510929-150510929	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.203C>T; p.P68L; 1:150509742-150509742	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.33G>T; p.L11F; 1:150508242-150508242	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.779C>T; p.T260M; 1:150511527-150511527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.554G>A; p.R185H; 1:150511044-150511044	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1441C>T; p.R481*; 1:150513285-150513285	prostate	carcinoma	Substitution - Nonsense
c.554G>A; p.R185H; 1:150511044-150511044	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1195C>T; p.R399W; 1:150512463-150512463	urinary_tract; bladder	carcinoma	Substitution - Missense
c.147A>T; p.P49P; 1:150509686-150509686	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1557C>T; p.G519G; 1:150513401-150513401	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.310C>T; p.P104S; 1:150510107-150510107	skin	malignant_melanoma	Substitution - Missense
c.1144T>A; p.L382M; 1:150512412-150512412	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.406G>A; p.D136N; 1:150510896-150510896	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.A240T; 1:150511466-150511466	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1519G>T; p.V507L; 1:150513363-150513363	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1429C>T; p.R477C; 1:150513273-150513273	oesophagus	carcinoma	Substitution - Missense
c.588A>G; p.P196P; 1:150511078-150511078	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.884T>G; p.L295R; 1:150511632-150511632	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.588A>G; p.P196P; 1:150511078-150511078	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.778A>G; p.T260A; 1:150511526-150511526	skin	malignant_melanoma	Substitution - Missense
c.1571G>C; p.G524A; 1:150513415-150513415	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.512G>A; p.R171Q; 1:150511002-150511002	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1571G>C; p.G524A; 1:150513415-150513415	central_nervous_system; medulla	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.301G>A; p.E101K; 1:150509999-150509999	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.358C>G; p.L120V; 1:150510155-150510155	breast	carcinoma	Substitution - Missense
c.1114C>T; p.R372W; 1:150512382-150512382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.624G>C; p.E208D; 1:150511114-150511114	breast	carcinoma	Substitution - Missense
c.1427G>A; p.R476Q; 1:150513271-150513271	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.801C>T; p.F267F; 1:150511549-150511549	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.807C>T; p.C269C; 1:150511555-150511555	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1427G>A; p.R476Q; 1:150513271-150513271	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1208C>T; p.P403L; 1:150512476-150512476	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.856A>G; p.S286G; 1:150511604-150511604	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.786delG; p.E264fs*52; 1:150511534-150511534	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.427G>A; p.E143K; 1:150510917-150510917	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1087G>A; p.E363K; 1:150512355-150512355	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.861T>G; p.H287Q; 1:150511609-150511609	prostate	carcinoma	Substitution - Missense
c.71-2A>C; p.?; 1:150509529-150509529	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.897C>T; p.F299F; 1:150511645-150511645	skin	malignant_melanoma	Substitution - coding silent
c.990C>T; p.P330P; 1:150511738-150511738	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1467G>C; p.L489L; 1:150513311-150513311	prostate	carcinoma	Substitution - coding silent
c.511C>T; p.R171W; 1:150511001-150511001	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.634T>G; p.F212V; 1:150511124-150511124	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1402T>G; p.F468V; 1:150513246-150513246	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.575C>A; p.P192H; 1:150511065-150511065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.431C>T; p.S144F; 1:150510921-150510921	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1307A>C; p.K436T; 1:150512727-150512727	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.715G>A; p.E239K; 1:150511463-150511463	urinary_tract; bladder	carcinoma	Substitution - Missense
c.143C>T; p.S48F; 1:150509682-150509682	skin	malignant_melanoma	Substitution - Missense
c.715G>A; p.E239K; 1:150511463-150511463	urinary_tract; bladder	carcinoma	Substitution - Missense
c.741C>T; p.A247A; 1:150511489-150511489	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.844C>T; p.R282W; 1:150511592-150511592	liver	carcinoma	Substitution - Missense
c.844C>T; p.R282W; 1:150511592-150511592	liver	carcinoma	Substitution - Missense
c.197G>A; p.G66D; 1:150509736-150509736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.148delC; p.L51fs*127; 1:150509687-150509687	skin; back	malignant_melanoma	Deletion - Frameshift
c.414C>T; p.S138S; 1:150510904-150510904	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.622G>A; p.E208K; 1:150511112-150511112	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.622G>A; p.E208K; 1:150511112-150511112	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1006C>A; p.L336M; 1:150511754-150511754	breast	carcinoma	Substitution - Missense
c.949C>T; p.R317C; 1:150511697-150511697	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.141C>A; p.P47P; 1:150509680-150509680	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1329C>T; p.H443H; 1:150512749-150512749	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1329C>T; p.H443H; 1:150512749-150512749	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1190C>T; p.A397V; 1:150512458-150512458	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1460G>T; p.C487F; 1:150513304-150513304	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1460G>T; p.C487F; 1:150513304-150513304	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1525C>G; p.L509V; 1:150513369-150513369	large_intestine; rectum	NS	Substitution - Missense
c.435G>A; p.W145*; 1:150510925-150510925	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.338T>C; p.L113P; 1:150510135-150510135	breast	carcinoma	Substitution - Missense
c.1414C>T; p.L472L; 1:150513258-150513258	ovary	other; neoplasm	Substitution - coding silent
c.674G>C; p.S225T; 1:150511164-150511164	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1512G>A; p.L504L; 1:150513356-150513356	parathyroid	carcinoma	Substitution - coding silent
c.993A>G; p.L331L; 1:150511741-150511741	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1020G>C; p.Q340H; 1:150511768-150511768	NS	NS	Substitution - Missense
c.922A>T; p.N308Y; 1:150511670-150511670	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1193G>A; p.R398H; 1:150512461-150512461	urinary_tract; bladder	carcinoma	Substitution - Missense
c.854C>T; p.P285L; 1:150511602-150511602	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.226C>T; p.Q76*; 1:150509924-150509924	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.691G>T; p.E231*; 1:150511181-150511181	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.691G>T; p.E231*; 1:150511181-150511181	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.319C>T; p.P107S; 1:150510116-150510116	skin	malignant_melanoma	Substitution - Missense
c.691G>T; p.E231*; 1:150511181-150511181	large_intestine; colon	carcinoma	Substitution - Nonsense
c.691G>T; p.E231*; 1:150511181-150511181	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.534C>T; p.N178N; 1:150511024-150511024	pancreas	carcinoma	Substitution - coding silent
c.1242C>T; p.I414I; 1:150512510-150512510	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.157C>T; p.R53*; 1:150509696-150509696	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.251C>T; p.T84I; 1:150509949-150509949	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.251C>T; p.T84I; 1:150509949-150509949	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.129C>T; p.Y43Y; 1:150509668-150509668	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1371G>C; p.Q457H; 1:150512791-150512791	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.829C>T; p.P277S; 1:150511577-150511577	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.983C>T; p.T328I; 1:150511731-150511731	kidney	other; neoplasm	Substitution - Missense

COSMIC somatic mutation [Top]