Entrez Gene

Basic Information
Gene ID	1627
Name	DBN1
Synonymous	drebrin 1;DBN1;drebrin 1
Definition	developmentally-regulated brain protein\|drebrin\|drebrin E\|drebrin E2\|drebrin-1
Position	5q35.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1225G>A; p.A409T; 5:177458609-177458609	breast	carcinoma	Substitution - Missense
c.831G>A; p.E277E; 5:177460644-177460644	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.568C>A; p.L190M; 5:177467050-177467050	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.583_585delGAG; p.E195delE; 5:177467033-177467035	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.285G>C; p.K95N; 5:177467788-177467788	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1904C>T; p.A635V; 5:177457479-177457479	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1909C>G; p.P637A; 5:177457474-177457474	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749G>T; p.R250L; 5:177466794-177466794	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1064C>T; p.A355V; 5:177459160-177459160	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.833A>T; p.E278V; 5:177460554-177460554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1939G>A; p.G647S; 5:177457444-177457444	skin	malignant_melanoma	Substitution - Missense
c.879C>A; p.F293L; 5:177460508-177460508	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1658C>T; p.S553F; 5:177458176-177458176	skin	malignant_melanoma	Substitution - Missense
c.775G>A; p.D259N; 5:177460700-177460700	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.619G>A; p.E207K; 5:177466999-177466999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1011C>T; p.S337S; 5:177459213-177459213	thyroid	carcinoma	Substitution - coding silent
c.115G>A; p.D39N; 5:177468871-177468871	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1184A>G; p.Q395R; 5:177458650-177458650	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.238T>C; p.Y80H; 5:177468125-177468125	skin	malignant_melanoma	Substitution - Missense
c.1309G>T; p.E437*; 5:177458525-177458525	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.645G>T; p.R215R; 5:177466973-177466973	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1920A>G; p.E640E; 5:177457463-177457463	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1920A>G; p.E640E; 5:177457463-177457463	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.847A>C; p.I283L; 5:177460540-177460540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.126G>A; p.K42K; 5:177468860-177468860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.556-2A>G; p.?; 5:177467064-177467064	lung	carcinoma; adenocarcinoma	Unknown
c.668G>A; p.R223Q; 5:177466950-177466950	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.516G>C; p.M172I; 5:177467294-177467294	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.668G>A; p.R223Q; 5:177466950-177466950	skin	malignant_melanoma	Substitution - Missense
c.614G>A; p.R205K; 5:177467004-177467004	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1345G>A; p.A449T; 5:177458489-177458489	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.571C>T; p.R191W; 5:177467047-177467047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.A199T; 5:177467023-177467023	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.575_577delAGG; p.E195delE; 5:177467041-177467043	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1794C>G; p.F598L; 5:177457740-177457740	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.905C>T; p.S302L; 5:177460482-177460482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1069G>A; p.D357N; 5:177459155-177459155	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1327G>A; p.A443T; 5:177458507-177458507	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.546G>T; p.E182D; 5:177467264-177467264	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1139C>T; p.P380L; 5:177458695-177458695	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.936G>A; p.S312S; 5:177460451-177460451	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.485C>A; p.T162N; 5:177467325-177467325	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1066C>A; p.L356M; 5:177459158-177459158	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1341C>G; p.H447Q; 5:177458493-177458493	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1446C>T; p.N482N; 5:177458388-177458388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.821C>T; p.S274L; 5:177460654-177460654	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1776+1G>C; p.?; 5:177458057-177458057	breast	carcinoma	Unknown
c.821C>T; p.S274L; 5:177460654-177460654	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1233C>T; p.P411P; 5:177458601-177458601	skin	malignant_melanoma	Substitution - coding silent
c.552C>T; p.A184A; 5:177467258-177467258	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1060C>T; p.R354W; 5:177459164-177459164	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1918G>C; p.E640Q; 5:177457465-177457465	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.623A>G; p.Q208R; 5:177466995-177466995	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1751A>G; p.E584G; 5:177458083-177458083	urinary_tract; bladder	carcinoma	Substitution - Missense
c.628C>T; p.R210W; 5:177466990-177466990	thyroid	carcinoma	Substitution - Missense
c.1750G>A; p.E584K; 5:177458084-177458084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1672delC; p.Q558fs*23; 5:177458162-177458162	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.1750G>A; p.E584K; 5:177458084-177458084	breast	carcinoma	Substitution - Missense
c.677G>A; p.R226Q; 5:177466941-177466941	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1414G>A; p.A472T; 5:177458420-177458420	liver	carcinoma	Substitution - Missense
c.1414G>A; p.A472T; 5:177458420-177458420	liver	carcinoma	Substitution - Missense
c.1414G>A; p.A472T; 5:177458420-177458420	ovary	other; neoplasm	Substitution - Missense
c.833A>G; p.E278G; 5:177460554-177460554	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.833A>G; p.E278G; 5:177460554-177460554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.833A>G; p.E278G; 5:177460554-177460554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.833A>G; p.E278G; 5:177460554-177460554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1307T>G; p.V436G; 5:177458527-177458527	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1781G>T; p.S594I; 5:177457753-177457753	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1195G>A; p.G399S; 5:177458639-177458639	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1903G>A; p.A635T; 5:177457480-177457480	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.914C>T; p.A305V; 5:177460473-177460473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.732G>A; p.A244A; 5:177466811-177466811	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1855C>T; p.P619S; 5:177457679-177457679	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.667C>T; p.R223W; 5:177466951-177466951	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.445C>T; p.R149W; 5:177467513-177467513	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.663C>T; p.R221R; 5:177466955-177466955	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.663C>T; p.R221R; 5:177466955-177466955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1336A>G; p.I446V; 5:177458498-177458498	thyroid	other; neoplasm	Substitution - Missense
c.281G>A; p.R94H; 5:177467792-177467792	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1336A>G; p.I446V; 5:177458498-177458498	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.318G>A; p.A106A; 5:177467755-177467755	thyroid	other; neoplasm	Substitution - coding silent
c.318G>A; p.A106A; 5:177467755-177467755	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1918G>A; p.E640K; 5:177457465-177457465	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>T; p.R250W; 5:177466795-177466795	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.832-1G>T; p.?; 5:177460556-177460556	breast	carcinoma; ductal_carcinoma	Unknown
c.164C>T; p.S55L; 5:177468199-177468199	breast	carcinoma	Substitution - Missense
c.1716G>A; p.E572E; 5:177458118-177458118	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.618C>T; p.F206F; 5:177467000-177467000	skin	malignant_melanoma	Substitution - coding silent
c.1634A>C; p.D545A; 5:177458200-177458200	skin	malignant_melanoma	Substitution - Missense
c.535C>T; p.Q179*; 5:177467275-177467275	skin	malignant_melanoma	Substitution - Nonsense
c.1007G>A; p.R336Q; 5:177459217-177459217	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1742C>G; p.T581S; 5:177458092-177458092	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1226C>T; p.A409V; 5:177458608-177458608	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1802C>T; p.S601L; 5:177457732-177457732	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1411G>A; p.A471T; 5:177458423-177458423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.900C>T; p.V300V; 5:177460487-177460487	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.900C>T; p.V300V; 5:177460487-177460487	pancreas	carcinoma	Substitution - coding silent
c.629G>A; p.R210Q; 5:177466989-177466989	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1322C>A; p.A441D; 5:177458512-177458512	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.175G>C; p.E59Q; 5:177468188-177468188	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1033T>G; p.S345A; 5:177459191-177459191	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1238G>A; p.G413E; 5:177458596-177458596	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.673T>A; p.Y225N; 5:177466945-177466945	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1834C>A; p.L612I; 5:177457700-177457700	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1107G>A; p.P369P; 5:177459117-177459117	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1107G>A; p.P369P; 5:177459117-177459117	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.465C>T; p.N155N; 5:177467493-177467493	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1356C>T; p.T452T; 5:177458478-177458478	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1045G>A; p.A349T; 5:177459179-177459179	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.832G>A; p.E278K; 5:177460555-177460555	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.477G>C; p.V159V; 5:177467481-177467481	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.787G>A; p.E263K; 5:177460688-177460688	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.660G>A; p.E220E; 5:177466958-177466958	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1831G>C; p.E611Q; 5:177457703-177457703	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.834G>T; p.E278D; 5:177460553-177460553	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.744G>C; p.K248N; 5:177466799-177466799	thyroid	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]