Entrez Gene

Basic Information
Gene ID	143689
Name	PIWIL4
Synonymous	piwi-like RNA-mediated gene silencing 4;PIWIL4;piwi-like RNA-mediated gene silencing 4
Definition	piwi-like 4\|piwi-like protein 4
Position	11q21
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2110A>G; p.I704V; 11:94618049-94618049	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.395C>T; p.P132L; 11:94577374-94577374	skin	malignant_melanoma	Substitution - Missense
c.475G>A; p.G159S; 11:94577454-94577454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2089G>A; p.D697N; 11:94618028-94618028	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.666T>C; p.I222I; 11:94585475-94585475	skin	malignant_melanoma	Substitution - coding silent
c.217G>A; p.G73S; 11:94575049-94575049	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.848G>T; p.R283I; 11:94587181-94587181	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2296T>C; p.Y766H; 11:94619998-94619998	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2247delC; p.P751fs*20; 11:94619838-94619838	stomach	adenocarcinoma	Deletion - Frameshift
c.601G>A; p.V201M; 11:94583535-94583535	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1047G>A; p.S349S; 11:94593538-94593538	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1283G>A; p.R428H; 11:94597818-94597818	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1636C>T; p.L546L; 11:94604054-94604054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1636C>T; p.L546L; 11:94604054-94604054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1042G>A; p.V348I; 11:94593533-94593533	prostate	carcinoma	Substitution - Missense
c.1915G>T; p.V639L; 11:94608658-94608658	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>C; p.E174D; 11:94583456-94583456	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.522G>C; p.E174D; 11:94583456-94583456	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Substitution - Missense
c.736T>C; p.F246L; 11:94587069-94587069	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1421G>A; p.R474Q; 11:94601835-94601835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1421G>A; p.R474Q; 11:94601835-94601835	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1421G>A; p.R474Q; 11:94601835-94601835	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1421G>A; p.R474Q; 11:94601835-94601835	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1540G>A; p.G514R; 11:94601954-94601954	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1479C>T; p.D493D; 11:94601893-94601893	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2233C>T; p.R745C; 11:94619824-94619824	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1668G>T; p.K556N; 11:94607468-94607468	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.495A>C; p.S165S; 11:94577474-94577474	prostate	adenoma	Substitution - coding silent
c.225A>C; p.K75N; 11:94575057-94575057	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2366A>T; p.Y789F; 11:94620068-94620068	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1431G>A; p.K477K; 11:94601845-94601845	breast	carcinoma	Substitution - coding silent
c.1952C>T; p.S651F; 11:94616501-94616501	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.410G>T; p.R137I; 11:94577389-94577389	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.39C>T; p.A13A; 11:94567557-94567557	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1306C>T; p.L436L; 11:94597841-94597841	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1313T>C; p.F438S; 11:94597848-94597848	NS	malignant_melanoma	Substitution - Missense
c.1313T>C; p.F438S; 11:94597848-94597848	NS	malignant_melanoma	Substitution - Missense
c.981G>A; p.Q327Q; 11:94589187-94589187	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.16C>T; p.R6*; 11:94567534-94567534	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.284G>T; p.R95I; 11:94575116-94575116	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.981G>A; p.Q327Q; 11:94589187-94589187	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1340G>A; p.R447Q; 11:94597875-94597875	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1340G>A; p.R447Q; 11:94597875-94597875	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.919A>G; p.N307D; 11:94589125-94589125	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1641A>G; p.V547V; 11:94607441-94607441	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.583C>T; p.L195L; 11:94583517-94583517	skin	malignant_melanoma	Substitution - coding silent
c.1108G>C; p.A370P; 11:94593599-94593599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.914+1G>A; p.?; 11:94587248-94587248	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.557A>C; p.K186T; 11:94583491-94583491	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1194T>G; p.A398A; 11:94595352-94595352	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1091G>T; p.R364I; 11:94593582-94593582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.237C>G; p.D79E; 11:94575069-94575069	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2059C>T; p.R687W; 11:94617998-94617998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.904G>A; p.V302I; 11:94587237-94587237	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2059C>T; p.R687W; 11:94617998-94617998	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1324A>G; p.I442V; 11:94597859-94597859	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2252C>T; p.P751L; 11:94619843-94619843	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2441C>T; p.P814L; 11:94620143-94620143	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1003A>C; p.T335P; 11:94589209-94589209	breast	carcinoma	Substitution - Missense
c.889C>T; p.L297L; 11:94587222-94587222	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2518G>A; p.E840K; 11:94620951-94620951	skin	malignant_melanoma	Substitution - Missense
c.1237C>T; p.R413C; 11:94595395-94595395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2261C>A; p.T754N; 11:94619852-94619852	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1849C>T; p.L617L; 11:94608592-94608592	skin	malignant_melanoma	Substitution - coding silent
c.1445A>T; p.Q482L; 11:94601859-94601859	liver	carcinoma	Substitution - Missense
c.1445A>T; p.Q482L; 11:94601859-94601859	liver	carcinoma	Substitution - Missense
c.1716_1717CC>TT; p.P573S; 11:94607516-94607517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1192G>A; p.A398T; 11:94595350-94595350	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2231A>G; p.N744S; 11:94619822-94619822	liver	carcinoma	Substitution - Missense
c.514-1G>A; p.?; 11:94583447-94583447	urinary_tract; bladder	carcinoma	Unknown
c.1132G>A; p.E378K; 11:94593623-94593623	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2224G>A; p.E742K; 11:94619815-94619815	skin	malignant_melanoma	Substitution - Missense
c.2224G>A; p.E742K; 11:94619815-94619815	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.226A>C; p.N76H; 11:94575058-94575058	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1212T>C; p.R404R; 11:94595370-94595370	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.996C>T; p.T332T; 11:94589202-94589202	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.324G>T; p.L108L; 11:94577303-94577303	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.185C>G; p.S62C; 11:94575017-94575017	breast	carcinoma	Substitution - Missense
c.711G>A; p.Q237Q; 11:94585520-94585520	thyroid	carcinoma	Substitution - coding silent
c.516C>A; p.V172V; 11:94583450-94583450	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1896C>T; p.D632D; 11:94608639-94608639	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1896C>T; p.D632D; 11:94608639-94608639	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1658C>A; p.S553Y; 11:94607458-94607458	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.980A>T; p.Q327L; 11:94589186-94589186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.980A>T; p.Q327L; 11:94589186-94589186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1064T>C; p.M355T; 11:94593555-94593555	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.1215C>G; p.L405L; 11:94595373-94595373	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1064T>C; p.M355T; 11:94593555-94593555	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.1064T>C; p.M355T; 11:94593555-94593555	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.1709G>A; p.C570Y; 11:94607509-94607509	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2251C>T; p.P751S; 11:94619842-94619842	skin	malignant_melanoma	Substitution - Missense
c.738T>C; p.F246F; 11:94587071-94587071	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1711C>T; p.P571S; 11:94607511-94607511	urinary_tract; bladder	carcinoma	Substitution - Missense
c.37G>A; p.A13T; 11:94567555-94567555	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.77C>T; p.A26V; 11:94567595-94567595	skin	malignant_melanoma	Substitution - Missense
c.670C>T; p.R224W; 11:94585479-94585479	prostate	adenoma	Substitution - Missense
c.670C>T; p.R224W; 11:94585479-94585479	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.1117G>A; p.A373T; 11:94593608-94593608	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>A; p.D56N; 11:94568808-94568808	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1848C>T; p.S616S; 11:94608591-94608591	skin	malignant_melanoma	Substitution - coding silent
c.1408T>C; p.S470P; 11:94601822-94601822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1815C>T; p.G605G; 11:94607615-94607615	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1914C>T; p.C638C; 11:94608657-94608657	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1302G>C; p.W434C; 11:94597837-94597837	breast	carcinoma	Substitution - Missense
c.187G>C; p.G63R; 11:94575019-94575019	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.963G>A; p.K321K; 11:94589169-94589169	skin	malignant_melanoma	Substitution - coding silent
c.1732C>T; p.L578F; 11:94607532-94607532	skin	malignant_melanoma	Substitution - Missense
c.105T>A; p.L35L; 11:94568747-94568747	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.52G>C; p.A18P; 11:94567570-94567570	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.739G>A; p.A247T; 11:94587072-94587072	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.685C>T; p.P229S; 11:94585494-94585494	breast	carcinoma	Substitution - Missense
c.2044C>G; p.H682D; 11:94617983-94617983	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.926G>T; p.R309I; 11:94589132-94589132	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1294G>T; p.E432*; 11:94597829-94597829	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.147A>C; p.T49T; 11:94568789-94568789	breast	carcinoma	Substitution - coding silent
c.2184G>A; p.V728V; 11:94619775-94619775	skin	malignant_melanoma	Substitution - coding silent
c.1771A>G; p.I591V; 11:94607571-94607571	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.81G>A; p.S27S; 11:94567599-94567599	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.L372L; 11:94593607-94593607	skin	malignant_melanoma	Substitution - coding silent
c.167-7G>A; p.?; 11:94574992-94574992	liver	carcinoma	Unknown
c.409A>G; p.R137G; 11:94577388-94577388	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1810G>A; p.G604R; 11:94607610-94607610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.460G>T; p.A154S; 11:94577439-94577439	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1011G>T; p.V337V; 11:94589217-94589217	breast	carcinoma	Substitution - coding silent
c.1210C>T; p.R404C; 11:94595368-94595368	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.2518G>T; p.E840*; 11:94620951-94620951	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.152G>A; p.R51K; 11:94568794-94568794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1135C>T; p.L379F; 11:94593626-94593626	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1151-1G>A; p.?; 11:94595308-94595308	skin; arm	malignant_melanoma	Unknown
c.1897G>A; p.V633M; 11:94608640-94608640	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2352C>T; p.Y784Y; 11:94620054-94620054	ovary	other; neoplasm	Substitution - coding silent
c.263G>C; p.R88T; 11:94575095-94575095	urinary_tract; bladder	carcinoma	Substitution - Missense
c.263G>C; p.R88T; 11:94575095-94575095	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.65G>A; p.G22E; 11:94567583-94567583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>T; p.E170*; 11:94577487-94577487	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.508G>T; p.E170*; 11:94577487-94577487	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2559A>G; p.*853W; 11:94620992-94620992	large_intestine	carcinoma; adenocarcinoma	Nonstop extension
c.2234G>A; p.R745H; 11:94619825-94619825	ovary	other; neoplasm	Substitution - Missense
c.1497C>T; p.A499A; 11:94601911-94601911	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.751T>C; p.S251P; 11:94587084-94587084	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2090A>G; p.D697G; 11:94618029-94618029	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1293A>G; p.L431L; 11:94597828-94597828	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2376C>T; p.N792N; 11:94620078-94620078	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1230G>A; p.R410R; 11:94595388-94595388	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1476C>T; p.S492S; 11:94601890-94601890	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2075G>A; p.R692H; 11:94618014-94618014	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]