Entrez Gene

Basic Information
Gene ID	1268
Name	CNR1
Synonymous	cannabinoid receptor 1 (brain);CNR1;cannabinoid receptor 1 (brain)
Definition	cannabinoid receptor 1\|central cannabinoid receptor
Position	6q14-q15
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.297G>A; p.G99G; 6:88144978-88144978	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.115T>C; p.S39P; 6:88145160-88145160	liver	carcinoma	Substitution - Missense
c.115T>C; p.S39P; 6:88145160-88145160	liver	carcinoma	Substitution - Missense
c.790T>C; p.C264R; 6:88144485-88144485	ovary	other; neoplasm	Substitution - Missense
c.115T>C; p.S39P; 6:88145160-88145160	liver	carcinoma	Substitution - Missense
c.650C>A; p.S217Y; 6:88144625-88144625	thyroid	carcinoma	Substitution - Missense
c.1215A>G; p.R405R; 6:88144060-88144060	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1050G>A; p.V350V; 6:88144225-88144225	skin; upper_arm	malignant_melanoma	Substitution - coding silent
c.1256C>T; p.A419V; 6:88144019-88144019	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.920G>A; p.R307H; 6:88144355-88144355	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.677G>T; p.R226M; 6:88144598-88144598	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.497_498GG>AA; p.G166E; 6:88144777-88144778	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.174C>T; p.F58F; 6:88145101-88145101	skin	malignant_melanoma	Substitution - coding silent
c.174C>T; p.F58F; 6:88145101-88145101	skin	malignant_melanoma	Substitution - coding silent
c.1257G>A; p.A419A; 6:88144018-88144018	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.736G>A; p.V246M; 6:88144539-88144539	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.174C>T; p.F58F; 6:88145101-88145101	skin	malignant_melanoma	Substitution - coding silent
c.238G>A; p.E80K; 6:88145037-88145037	skin	malignant_melanoma	Substitution - Missense
c.1009A>G; p.M337V; 6:88144266-88144266	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.258C>G; p.L86L; 6:88145017-88145017	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1073C>A; p.P358H; 6:88144202-88144202	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1408G>A; p.E470K; 6:88143867-88143867	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.133C>T; p.P45S; 6:88145142-88145142	skin	malignant_melanoma	Substitution - Missense
c.382A>T; p.T128S; 6:88144893-88144893	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.822C>A; p.T274T; 6:88144453-88144453	prostate	adenoma	Substitution - coding silent
c.862C>A; p.L288M; 6:88144413-88144413	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.852C>T; p.S284S; 6:88144423-88144423	pancreas	carcinoma	Substitution - coding silent
c.1318G>T; p.A440S; 6:88143957-88143957	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1019G>C; p.R340T; 6:88144256-88144256	breast	carcinoma	Substitution - Missense
c.1059C>T; p.I353I; 6:88144216-88144216	skin	malignant_melanoma	Substitution - coding silent
c.320G>T; p.C107F; 6:88144955-88144955	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1068G>T; p.W356C; 6:88144207-88144207	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1011G>T; p.M337I; 6:88144264-88144264	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.568C>G; p.L190V; 6:88144707-88144707	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1214G>A; p.R405Q; 6:88144061-88144061	skin	malignant_melanoma	Substitution - Missense
c.1214G>A; p.R405Q; 6:88144061-88144061	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1238C>T; p.P413L; 6:88144037-88144037	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.479C>T; p.A160V; 6:88144796-88144796	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1161G>A; p.L387L; 6:88144114-88144114	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.69G>A; p.V23V; 6:88145206-88145206	skin	malignant_melanoma	Substitution - coding silent
c.1122C>T; p.L374L; 6:88144153-88144153	skin	malignant_melanoma	Substitution - coding silent
c.1065C>A; p.C355*; 6:88144210-88144210	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.932G>A; p.R311H; 6:88144343-88144343	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.932G>A; p.R311H; 6:88144343-88144343	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.270G>A; p.K90K; 6:88145005-88145005	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.624C>T; p.F208F; 6:88144651-88144651	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.624C>T; p.F208F; 6:88144651-88144651	skin	malignant_melanoma	Substitution - coding silent
c.1048G>C; p.V350L; 6:88144227-88144227	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.203_204CC>TT; p.P68L; 6:88145071-88145072	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.476T>C; p.L159P; 6:88144799-88144799	breast	carcinoma	Substitution - Missense
c.220G>A; p.D74N; 6:88145055-88145055	skin	malignant_melanoma	Substitution - Missense
c.1358C>T; p.T453M; 6:88143917-88143917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1002A>T; p.Q334H; 6:88144273-88144273	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1319C>T; p.A440V; 6:88143956-88143956	large_intestine	adenoma	Substitution - Missense
c.369C>A; p.S123S; 6:88144906-88144906	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.674A>G; p.K225R; 6:88144601-88144601	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1213C>T; p.R405*; 6:88144062-88144062	liver	carcinoma	Substitution - Nonsense
c.707C>T; p.A236V; 6:88144568-88144568	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1213C>T; p.R405*; 6:88144062-88144062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.612G>A; p.V204V; 6:88144663-88144663	skin	malignant_melanoma	Substitution - coding silent
c.238G>C; p.E80Q; 6:88145037-88145037	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.469G>A; p.G157S; 6:88144806-88144806	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.651C>T; p.S217S; 6:88144624-88144624	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.90C>T; p.Y30Y; 6:88145185-88145185	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.90C>T; p.Y30Y; 6:88145185-88145185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.90C>T; p.Y30Y; 6:88145185-88145185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.892C>A; p.L298I; 6:88144383-88144383	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1128G>A; p.K376K; 6:88144147-88144147	skin	malignant_melanoma	Substitution - coding silent
c.374C>G; p.T125R; 6:88144901-88144901	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.583G>A; p.G195R; 6:88144692-88144692	skin	malignant_melanoma	Substitution - Missense
c.853G>A; p.V285I; 6:88144422-88144422	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.853G>A; p.V285I; 6:88144422-88144422	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1011G>A; p.M337I; 6:88144264-88144264	skin; extremity	malignant_melanoma	Substitution - Missense
c.1011G>A; p.M337I; 6:88144264-88144264	skin	malignant_melanoma	Substitution - Missense
c.792C>T; p.C264C; 6:88144483-88144483	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.138G>C; p.Q46H; 6:88145137-88145137	urinary_tract; bladder	carcinoma	Substitution - Missense
c.345G>A; p.Q115Q; 6:88144930-88144930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.723G>A; p.W241*; 6:88144552-88144552	skin	malignant_melanoma	Substitution - Nonsense
c.1287G>A; p.S429S; 6:88143988-88143988	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.100A>G; p.K34E; 6:88145175-88145175	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.556C>A; p.R186S; 6:88144719-88144719	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.269A>G; p.K90R; 6:88145006-88145006	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.339C>T; p.P113P; 6:88144936-88144936	skin	malignant_melanoma	Substitution - coding silent
c.659G>A; p.R220K; 6:88144616-88144616	skin; shoulder	malignant_melanoma	Substitution - Missense
c.765G>A; p.W255*; 6:88144510-88144510	skin; scalp	malignant_melanoma	Substitution - Nonsense
c.992G>A; p.R331Q; 6:88144283-88144283	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.336C>T; p.N112N; 6:88144939-88144939	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.606C>A; p.A202A; 6:88144669-88144669	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.229A>T; p.N77Y; 6:88145046-88145046	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.791G>T; p.C264F; 6:88144484-88144484	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.645C>T; p.Y215Y; 6:88144630-88144630	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.443G>A; p.R148H; 6:88144832-88144832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.443G>A; p.R148H; 6:88144832-88144832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.126G>A; p.G42G; 6:88145149-88145149	liver	carcinoma	Substitution - coding silent
c.126G>A; p.G42G; 6:88145149-88145149	liver	carcinoma	Substitution - coding silent
c.741C>T; p.I247I; 6:88144534-88144534	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.480G>A; p.A160A; 6:88144795-88144795	breast	carcinoma	Substitution - coding silent
c.155C>T; p.S52F; 6:88145120-88145120	skin	malignant_melanoma	Substitution - Missense
c.841G>A; p.G281R; 6:88144434-88144434	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.669C>A; p.A223A; 6:88144606-88144606	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1007G>A; p.R336H; 6:88144268-88144268	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.408G>T; p.L136L; 6:88144867-88144867	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.91G>A; p.E31K; 6:88145184-88145184	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.254C>A; p.S85Y; 6:88145021-88145021	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.91G>A; p.E31K; 6:88145184-88145184	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.570G>A; p.L190L; 6:88144705-88144705	liver	carcinoma	Substitution - coding silent
c.570G>A; p.L190L; 6:88144705-88144705	liver	carcinoma	Substitution - coding silent
c.744C>T; p.A248A; 6:88144531-88144531	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.67G>A; p.V23M; 6:88145208-88145208	prostate	carcinoma	Substitution - Missense
c.335A>C; p.N112T; 6:88144940-88144940	thyroid	other; neoplasm	Substitution - Missense
c.963G>A; p.T321T; 6:88144312-88144312	stomach	adenocarcinoma	Substitution - coding silent
c.762C>T; p.G254G; 6:88144513-88144513	skin	malignant_melanoma	Substitution - coding silent
c.762C>T; p.G254G; 6:88144513-88144513	skin	malignant_melanoma	Substitution - coding silent
c.298G>A; p.E100K; 6:88144977-88144977	skin	malignant_melanoma	Substitution - Missense
c.295G>C; p.G99R; 6:88144980-88144980	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.700G>A; p.V234M; 6:88144575-88144575	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.957C>T; p.I319I; 6:88144318-88144318	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.677G>A; p.R226K; 6:88144598-88144598	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.677G>A; p.R226K; 6:88144598-88144598	skin	malignant_melanoma	Substitution - Missense
c.644A>G; p.Y215C; 6:88144631-88144631	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1406C>T; p.A469V; 6:88143869-88143869	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.838A>T; p.I280F; 6:88144437-88144437	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1226G>A; p.R409Q; 6:88144049-88144049	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.273G>T; p.E91D; 6:88145002-88145002	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.774G>T; p.E258D; 6:88144501-88144501	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>T; p.F174F; 6:88144753-88144753	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.609C>T; p.S203S; 6:88144666-88144666	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.62_85del24; p.L21_I28delLYVGSNDI; 6:88145190-88145213	ovary	carcinoma; serous_carcinoma	Deletion - In frame
c.637G>C; p.D213H; 6:88144638-88144638	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.559A>T; p.N187Y; 6:88144716-88144716	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.559A>T; p.N187Y; 6:88144716-88144716	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.675G>A; p.K225K; 6:88144600-88144600	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.468C>T; p.I156I; 6:88144807-88144807	skin; hand	malignant_melanoma	Substitution - coding silent
c.871G>A; p.V291M; 6:88144404-88144404	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.26C>A; p.A9E; 6:88145249-88145249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.40C>T; p.R14C; 6:88145235-88145235	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1143C>A; p.F381L; 6:88144132-88144132	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.36C>T; p.T12T; 6:88145239-88145239	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1044C>T; p.I348I; 6:88144231-88144231	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1044C>T; p.I348I; 6:88144231-88144231	skin	malignant_melanoma	Substitution - coding silent
c.1389G>A; p.V463V; 6:88143886-88143886	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.155C>A; p.S52Y; 6:88145120-88145120	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.314T>C; p.I105T; 6:88144961-88144961	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.434G>A; p.R145H; 6:88144841-88144841	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.954C>T; p.I318I; 6:88144321-88144321	skin	malignant_melanoma	Substitution - coding silent
c.708G>A; p.A236A; 6:88144567-88144567	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.878C>T; p.A293V; 6:88144397-88144397	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.878C>T; p.A293V; 6:88144397-88144397	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.708G>A; p.A236A; 6:88144567-88144567	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1072C>A; p.P358T; 6:88144203-88144203	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.180G>C; p.E60D; 6:88145095-88145095	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1237C>T; p.P413S; 6:88144038-88144038	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1237C>T; p.P413S; 6:88144038-88144038	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1237C>T; p.P413S; 6:88144038-88144038	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.742G>A; p.A248T; 6:88144533-88144533	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.583G>T; p.G195W; 6:88144692-88144692	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.583G>T; p.G195W; 6:88144692-88144692	large_intestine; colon	carcinoma	Substitution - Missense
c.583G>T; p.G195W; 6:88144692-88144692	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.364C>A; p.L122M; 6:88144911-88144911	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1130C>T; p.T377M; 6:88144145-88144145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1130C>T; p.T377M; 6:88144145-88144145	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1130C>T; p.T377M; 6:88144145-88144145	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1130C>T; p.T377M; 6:88144145-88144145	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.772G>A; p.E258K; 6:88144503-88144503	skin	malignant_melanoma	Substitution - Missense
c.905A>C; p.H302P; 6:88144370-88144370	skin	malignant_melanoma	Substitution - Missense
c.591G>A; p.T197T; 6:88144684-88144684	liver	carcinoma	Substitution - coding silent
c.28G>C; p.D10H; 6:88145247-88145247	skin; ankle	malignant_melanoma	Substitution - Missense
c.1369G>T; p.A457S; 6:88143906-88143906	ovary	other; neoplasm	Substitution - Missense
c.743C>T; p.A248V; 6:88144532-88144532	skin	malignant_melanoma	Substitution - Missense
c.145C>T; p.P49S; 6:88145130-88145130	skin; ear	malignant_melanoma	Substitution - Missense
c.29A>G; p.D10G; 6:88145246-88145246	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1359G>A; p.T453T; 6:88143916-88143916	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.660G>T; p.R220S; 6:88144615-88144615	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1359G>A; p.T453T; 6:88143916-88143916	thyroid	other; neoplasm	Substitution - coding silent
c.934G>A; p.G312S; 6:88144341-88144341	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.870C>T; p.I290I; 6:88144405-88144405	skin	malignant_melanoma	Substitution - coding silent
c.984G>A; p.Q328Q; 6:88144291-88144291	skin	malignant_melanoma	Substitution - coding silent
c.924G>T; p.M308I; 6:88144351-88144351	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.919C>T; p.R307C; 6:88144356-88144356	skin	malignant_melanoma	Substitution - Missense
c.919C>T; p.R307C; 6:88144356-88144356	skin	malignant_melanoma	Substitution - Missense
c.903T>C; p.A301A; 6:88144372-88144372	central_nervous_system; brain	glioma	Substitution - coding silent

COSMIC somatic mutation [Top]