Entrez Gene

Basic Information
Gene ID	118856
Name	MMP21
Synonymous	matrix metallopeptidase 21;MMP21;matrix metallopeptidase 21
Definition	matrix metalloproteinase 21\|matrix metalloproteinase-21
Position	10q26.13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.228G>A; p.P76P; 10:125774300-125774300	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.870C>A; p.G290G; 10:125772327-125772327	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.863T>G; p.V288G; 10:125772334-125772334	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.718C>T; p.R240W; 10:125772730-125772730	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.150C>G; p.L50L; 10:125775672-125775672	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.187T>G; p.S63A; 10:125774341-125774341	thyroid	other; neoplasm	Substitution - Missense
c.1142A>C; p.Q381P; 10:125770429-125770429	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.814G>A; p.D272N; 10:125772634-125772634	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.664G>T; p.A222S; 10:125773864-125773864	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.945C>G; p.D315E; 10:125772252-125772252	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1354G>C; p.D452H; 10:125767588-125767588	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1354G>C; p.D452H; 10:125767588-125767588	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.97C>T; p.R33C; 10:125775725-125775725	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.145G>A; p.D49N; 10:125775677-125775677	large_intestine; colon	NS	Substitution - Missense
c.572T>C; p.V191A; 10:125773956-125773956	thyroid	other; neoplasm	Substitution - Missense
c.572T>C; p.V191A; 10:125773956-125773956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.153C>T; p.H51H; 10:125775669-125775669	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.789C>T; p.D263D; 10:125772659-125772659	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1302A>C; p.K434N; 10:125767640-125767640	liver	carcinoma	Substitution - Missense
c.1525G>A; p.A509T; 10:125766847-125766847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1525G>A; p.A509T; 10:125766847-125766847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1469C>G; p.T490S; 10:125766903-125766903	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1554T>C; p.I518I; 10:125766818-125766818	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1007C>T; p.A336V; 10:125770564-125770564	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.660delC; p.A222fs*34; 10:125773868-125773868	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1523C>T; p.S508F; 10:125766849-125766849	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.9C>T; p.A3A; 10:125775813-125775813	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1270G>A; p.D424N; 10:125767672-125767672	skin	malignant_melanoma	Substitution - Missense
c.980-4delT; p.?; 10:125770595-125770595	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.890C>T; p.T297M; 10:125772307-125772307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.890C>T; p.T297M; 10:125772307-125772307	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.22C>T; p.R8C; 10:125775800-125775800	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.22C>T; p.R8C; 10:125775800-125775800	skin	malignant_melanoma	Substitution - Missense
c.1109G>A; p.R370Q; 10:125770462-125770462	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.922C>A; p.Q308K; 10:125772275-125772275	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1689T>C; p.H563H; 10:125766683-125766683	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1433G>A; p.R478K; 10:125766939-125766939	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1214G>T; p.R405I; 10:125770357-125770357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1214G>T; p.R405I; 10:125770357-125770357	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1214G>T; p.R405I; 10:125770357-125770357	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.486C>T; p.Y162Y; 10:125774042-125774042	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1049T>G; p.V350G; 10:125770522-125770522	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.70C>A; p.P24T; 10:125775752-125775752	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.7G>A; p.A3T; 10:125775815-125775815	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.A52T; 10:125775668-125775668	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.173C>A; p.S58Y; 10:125774355-125774355	liver	carcinoma	Substitution - Missense
c.173C>A; p.S58Y; 10:125774355-125774355	liver	carcinoma	Substitution - Missense
c.1298G>A; p.G433E; 10:125767644-125767644	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.120A>G; p.P40P; 10:125775702-125775702	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.354G>T; p.G118G; 10:125774174-125774174	liver	carcinoma	Substitution - coding silent
c.710G>T; p.G237V; 10:125772738-125772738	prostate	carcinoma	Substitution - Missense
c.354G>T; p.G118G; 10:125774174-125774174	liver	carcinoma	Substitution - coding silent
c.1125C>T; p.R375R; 10:125770446-125770446	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1048G>A; p.V350M; 10:125770523-125770523	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.124C>A; p.R42S; 10:125775698-125775698	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.891G>A; p.T297T; 10:125772306-125772306	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.586C>T; p.R196C; 10:125773942-125773942	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.655G>A; p.A219T; 10:125773873-125773873	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1043G>A; p.G348E; 10:125770528-125770528	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1447A>C; p.N483H; 10:125766925-125766925	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1265A>G; p.D422G; 10:125767677-125767677	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.787G>A; p.D263N; 10:125772661-125772661	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.64A>C; p.T22P; 10:125775758-125775758	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1051A>C; p.M351L; 10:125770520-125770520	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.891G>T; p.T297T; 10:125772306-125772306	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1277C>T; p.A426V; 10:125767665-125767665	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1277C>T; p.A426V; 10:125767665-125767665	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.992G>A; p.G331E; 10:125770579-125770579	skin	malignant_melanoma	Substitution - Missense
c.1687C>T; p.H563Y; 10:125766685-125766685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1466T>C; p.I489T; 10:125766906-125766906	ovary	other; neoplasm	Substitution - Missense
c.849T>C; p.H283H; 10:125772348-125772348	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.618C>T; p.S206S; 10:125773910-125773910	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1136C>G; p.P379R; 10:125770435-125770435	liver	carcinoma	Substitution - Missense
c.1136C>G; p.P379R; 10:125770435-125770435	liver	carcinoma	Substitution - Missense
c.1053G>T; p.M351I; 10:125770518-125770518	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.786C>T; p.D262D; 10:125772662-125772662	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1091A>G; p.Y364C; 10:125770480-125770480	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.669G>A; p.A223A; 10:125773859-125773859	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1031G>T; p.R344I; 10:125770540-125770540	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.570C>T; p.S190S; 10:125773958-125773958	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.570C>T; p.S190S; 10:125773958-125773958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.597G>A; p.A199A; 10:125773931-125773931	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.825C>G; p.I275M; 10:125772623-125772623	breast	carcinoma	Substitution - Missense
c.1219G>A; p.E407K; 10:125770352-125770352	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1381A>G; p.K461E; 10:125767561-125767561	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1016G>A; p.W339*; 10:125770555-125770555	skin	malignant_melanoma	Substitution - Nonsense
c.765A>G; p.L255L; 10:125772683-125772683	breast	carcinoma	Substitution - coding silent
c.1688A>G; p.H563R; 10:125766684-125766684	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.101C>G; p.S34W; 10:125775721-125775721	skin	malignant_melanoma	Substitution - Missense
c.23G>A; p.R8H; 10:125775799-125775799	pancreas	carcinoma	Substitution - Missense
c.889A>G; p.T297A; 10:125772308-125772308	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.889A>G; p.T297A; 10:125772308-125772308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.672C>T; p.V224V; 10:125773856-125773856	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.626C>T; p.T209M; 10:125773902-125773902	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.101C>T; p.S34L; 10:125775721-125775721	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1438C>T; p.R480*; 10:125766934-125766934	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1438C>T; p.R480*; 10:125766934-125766934	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.673G>A; p.D225N; 10:125773855-125773855	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.754G>T; p.A252S; 10:125772694-125772694	urinary_tract; bladder	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]