Entrez Gene

Basic Information
Gene ID	10724
Name	MGEA5
Synonymous	meningioma expressed antigen 5 (hyaluronidase);MGEA5;meningioma expressed antigen 5 (hyaluronidase)
Definition	N-acetyl-beta-D-glucosaminidase\|N-acetyl-beta-glucosaminidase\|O-GlcNAcase\|beta-N-acetylglucosaminidase\|beta-N-acetylhexosaminidase\|beta-hexosaminidase\|bifunctional protein NCOAT\|hyaluronidase in meningioma\|meningioma-expressed antigen 5\|nuclear cytoplasmi
Position	10q24.1-q24.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1075T>A; p.L359I; 10:101800362-101800362	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2716C>T; p.P906S; 10:101786486-101786486	skin	malignant_melanoma	Substitution - Missense
c.93G>T; p.P31P; 10:101817930-101817930	central_nervous_system; brain	glioma	Substitution - coding silent
c.793G>A; p.E265K; 10:101803978-101803978	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1321G>T; p.G441*; 10:101799330-101799330	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.661G>C; p.G221R; 10:101806135-101806135	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1564A>G; p.S522G; 10:101799087-101799087	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1898A>G; p.N633S; 10:101798066-101798066	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1564A>G; p.S522G; 10:101799087-101799087	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2513A>G; p.N838S; 10:101787465-101787465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.437C>T; p.S146F; 10:101810227-101810227	breast	carcinoma	Substitution - Missense
c.2325C>T; p.G775G; 10:101791025-101791025	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2453A>T; p.E818V; 10:101790897-101790897	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1470G>A; p.A490A; 10:101799181-101799181	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2283C>T; p.S761S; 10:101791067-101791067	skin	malignant_melanoma	Substitution - coding silent
c.2224T>G; p.L742V; 10:101791391-101791391	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2740C>T; p.R914W; 10:101786462-101786462	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1955C>T; p.S652F; 10:101798009-101798009	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.54C>T; p.S18S; 10:101817969-101817969	thyroid	other; neoplasm	Substitution - coding silent
c.1121A>G; p.Y374C; 10:101800316-101800316	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.940C>G; p.P314A; 10:101803831-101803831	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1022A>T; p.K341I; 10:101803749-101803749	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2145T>C; p.Y715Y; 10:101792869-101792869	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1053T>C; p.S351S; 10:101800384-101800384	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1654_1655CC>TT; p.P552L; 10:101798996-101798997	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2486A>G; p.E829G; 10:101787492-101787492	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1783A>G; p.N595D; 10:101798868-101798868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1345A>T; p.T449S; 10:101799306-101799306	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.569C>A; p.S190Y; 10:101807813-101807813	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1387_1389delGAA; p.E463delE; 10:101799262-101799264	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.1957A>G; p.M653V; 10:101798007-101798007	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.581C>T; p.A194V; 10:101807801-101807801	skin	malignant_melanoma	Substitution - Missense
c.1354A>G; p.T452A; 10:101799297-101799297	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1389A>G; p.E463E; 10:101799262-101799262	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.1244C>T; p.T415I; 10:101799407-101799407	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1244C>T; p.T415I; 10:101799407-101799407	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2143T>C; p.Y715H; 10:101792871-101792871	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.2522C>A; p.S841Y; 10:101787456-101787456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.608A>G; p.Y203C; 10:101807774-101807774	pancreas	carcinoma	Substitution - Missense
c.406G>A; p.A136T; 10:101810258-101810258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2286C>T; p.L762L; 10:101791064-101791064	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1718C>T; p.P573L; 10:101798933-101798933	skin; abdomen	malignant_melanoma	Substitution - Missense
c.1828_1829CG>TT; p.R610L; 10:101798135-101798136	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4G>T; p.V2L; 10:101818019-101818019	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.258G>T; p.Q86H; 10:101813121-101813121	breast	carcinoma	Substitution - Missense
c.460T>A; p.L154M; 10:101810204-101810204	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.429C>G; p.I143M; 10:101810235-101810235	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2504T>C; p.F835S; 10:101787474-101787474	urinary_tract; bladder	carcinoma	Substitution - Missense
c.909C>T; p.L303L; 10:101803862-101803862	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2453A>G; p.E818G; 10:101790897-101790897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2453A>G; p.E818G; 10:101790897-101790897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1247C>T; p.P416L; 10:101799404-101799404	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2086G>C; p.D696H; 10:101792928-101792928	breast	carcinoma	Substitution - Missense
c.1568A>G; p.D523G; 10:101799083-101799083	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2008C>T; p.Q670*; 10:101793975-101793975	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.772G>T; p.E258*; 10:101803999-101803999	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2173G>A; p.E725K; 10:101792841-101792841	skin	malignant_melanoma	Substitution - Missense
c.2620C>T; p.R874W; 10:101786582-101786582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.821C>G; p.A274G; 10:101803950-101803950	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2692G>T; p.E898*; 10:101786510-101786510	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2692G>T; p.E898*; 10:101786510-101786510	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.1138C>T; p.L380L; 10:101800299-101800299	pancreas	carcinoma	Substitution - coding silent
c.1929_1930insT; p.V644fs*22; 10:101798034-101798035	oesophagus; lower_third	carcinoma; adenocarcinoma	Insertion - Frameshift
c.388G>T; p.E130*; 10:101810276-101810276	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1578C>T; p.P526P; 10:101799073-101799073	skin	malignant_melanoma	Substitution - coding silent
c.824C>T; p.P275L; 10:101803947-101803947	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.163G>A; p.G55R; 10:101817860-101817860	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2095A>G; p.N699D; 10:101792919-101792919	ovary	other; neoplasm	Substitution - Missense
c.917G>A; p.R306Q; 10:101803854-101803854	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.22G>A; p.A8T; 10:101818001-101818001	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2537A>G; p.D846G; 10:101787441-101787441	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.264G>T; p.W88C; 10:101813115-101813115	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.628G>A; p.E210K; 10:101807754-101807754	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1196-1G>A; p.?; 10:101799456-101799456	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.481-10_481-8delTTT; p.?; 10:101807909-101807911	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.2269G>A; p.G757R; 10:101791081-101791081	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1990C>T; p.R664C; 10:101793993-101793993	liver	carcinoma	Substitution - Missense
c.1413delA; p.K471fs*14; 10:101799238-101799238	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1990C>T; p.R664C; 10:101793993-101793993	liver	carcinoma	Substitution - Missense
c.1929T>G; p.Y643*; 10:101798035-101798035	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.1618C>T; p.P540S; 10:101799033-101799033	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1282G>A; p.V428I; 10:101799369-101799369	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1247delC; p.P416fs*2; 10:101799404-101799404	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Deletion - Frameshift
c.736G>A; p.E246K; 10:101806060-101806060	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.215C>T; p.P72L; 10:101813591-101813591	skin	malignant_melanoma	Substitution - Missense
c.2584G>T; p.A862S; 10:101787394-101787394	liver	carcinoma	Substitution - Missense
c.1175G>T; p.G392V; 10:101800262-101800262	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2261+1G>A; p.?; 10:101791353-101791353	pancreas	carcinoma	Unknown
c.1785T>C; p.N595N; 10:101798866-101798866	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2200G>T; p.E734*; 10:101791415-101791415	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1424C>T; p.T475M; 10:101799227-101799227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2023G>T; p.D675Y; 10:101793960-101793960	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1650G>A; p.A550A; 10:101799001-101799001	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1655C>T; p.P552L; 10:101798996-101798996	pancreas	carcinoma	Substitution - Missense
c.1504G>A; p.D502N; 10:101799147-101799147	urinary_tract; bladder	carcinoma	Substitution - Missense
c.662G>T; p.G221V; 10:101806134-101806134	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1756C>T; p.R586*; 10:101798895-101798895	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1756C>T; p.R586*; 10:101798895-101798895	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1756C>T; p.R586*; 10:101798895-101798895	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.986C>T; p.A329V; 10:101803785-101803785	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2476G>A; p.E826K; 10:101787502-101787502	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1886C>T; p.S629F; 10:101798078-101798078	skin	malignant_melanoma	Substitution - Missense
c.1886C>T; p.S629F; 10:101798078-101798078	skin	malignant_melanoma	Substitution - Missense
c.1011T>C; p.N337N; 10:101803760-101803760	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1401G>C; p.M467I; 10:101799250-101799250	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.836A>T; p.D279V; 10:101803935-101803935	breast	carcinoma	Substitution - Missense
c.2522C>T; p.S841F; 10:101787456-101787456	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2387C>T; p.S796F; 10:101790963-101790963	skin; mucosal	malignant_melanoma	Substitution - Missense
c.550G>C; p.D184H; 10:101807832-101807832	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.665C>T; p.T222I; 10:101806131-101806131	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2090G>A; p.G697E; 10:101792924-101792924	liver	carcinoma	Substitution - Missense
c.577C>T; p.H193Y; 10:101807805-101807805	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1993A>G; p.S665G; 10:101793990-101793990	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2501C>A; p.T834N; 10:101787477-101787477	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1661C>T; p.T554I; 10:101798990-101798990	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2273G>T; p.G758V; 10:101791077-101791077	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2553A>G; p.V851V; 10:101787425-101787425	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1649C>T; p.A550V; 10:101799002-101799002	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1391C>A; p.P464H; 10:101799260-101799260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1649C>T; p.A550V; 10:101799002-101799002	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]