Entrez Gene

Basic Information
Gene ID	10501
Name	SEMA6B
Synonymous	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B;SEMA6B;sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Definition	semaphorin VIB\|semaphorin Z\|semaphorin-6B\|semaphorin-6Ba
Position	19p13.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.214C>T; p.R72W; 19:4558057-4558057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1863C>T; p.F621F; 19:4544405-4544405	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1092G>A; p.P364P; 19:4550828-4550828	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.555C>G; p.L185L; 19:4555481-4555481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2639C>T; p.A880V; 19:4543629-4543629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1022T>A; p.L341Q; 19:4550898-4550898	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1022T>A; p.L341Q; 19:4550898-4550898	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.260G>A; p.R87H; 19:4557209-4557209	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.591C>G; p.T197T; 19:4555067-4555067	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.185C>T; p.A62V; 19:4558086-4558086	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1034C>T; p.A345V; 19:4550886-4550886	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1546C>T; p.R516C; 19:4548082-4548082	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1300G>A; p.V434M; 19:4548417-4548417	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1009T>A; p.C337S; 19:4550911-4550911	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1232C>G; p.S411W; 19:4550162-4550162	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1405T>C; p.S469P; 19:4548312-4548312	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.943G>T; p.G315W; 19:4552468-4552468	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.711G>A; p.W237*; 19:4554448-4554448	skin	malignant_melanoma	Substitution - Nonsense
c.696C>T; p.V232V; 19:4554463-4554463	skin	malignant_melanoma	Substitution - coding silent
c.507C>T; p.S169S; 19:4555529-4555529	large_intestine; colon	NS	Substitution - coding silent
c.1048G>A; p.G350S; 19:4550872-4550872	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1245G>A; p.A415A; 19:4550149-4550149	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.747G>A; p.A249A; 19:4554412-4554412	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.334G>A; p.D112N; 19:4556986-4556986	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.528C>T; p.Y176Y; 19:4555508-4555508	liver	carcinoma	Substitution - coding silent
c.1545C>T; p.P515P; 19:4548083-4548083	skin	malignant_melanoma	Substitution - coding silent
c.205C>T; p.R69*; 19:4558066-4558066	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1124C>A; p.P375H; 19:4550270-4550270	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2658_2659insC; p.V887fs*>3; 19:4543609-4543610	autonomic_ganglia	neuroblastoma	Insertion - Frameshift
c.666C>T; p.D222D; 19:4554992-4554992	breast	carcinoma	Substitution - coding silent
c.1015T>G; p.F339V; 19:4550905-4550905	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.172C>T; p.P58S; 19:4558099-4558099	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.39G>C; p.L13L; 19:4558419-4558419	breast	carcinoma	Substitution - coding silent
c.39G>C; p.L13L; 19:4558419-4558419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.39G>C; p.L13L; 19:4558419-4558419	thyroid	other; neoplasm	Substitution - coding silent
c.39G>C; p.L13L; 19:4558419-4558419	breast	carcinoma	Substitution - coding silent
c.39G>C; p.L13L; 19:4558419-4558419	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1340T>C; p.L447P; 19:4548377-4548377	skin	malignant_melanoma	Substitution - Missense
c.493G>A; p.G165R; 19:4555543-4555543	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.572T>G; p.L191R; 19:4555086-4555086	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.262G>A; p.V88I; 19:4557207-4557207	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1397C>T; p.S466L; 19:4548320-4548320	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.229C>T; p.L77L; 19:4558042-4558042	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.65delG; p.G22fs*21; 19:4558393-4558393	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.248A>G; p.D83G; 19:4557221-4557221	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1873C>T; p.R625C; 19:4544395-4544395	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1732T>A; p.C578S; 19:4546222-4546222	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.786C>T; p.R262R; 19:4552625-4552625	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180G>A; p.D394N; 19:4550214-4550214	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1400G>A; p.G467E; 19:4548317-4548317	skin	malignant_melanoma	Substitution - Missense
c.761A>C; p.Y254S; 19:4554398-4554398	thyroid	other; neoplasm	Substitution - Missense
c.471C>T; p.S157S; 19:4555988-4555988	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.886G>A; p.G296R; 19:4552525-4552525	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1401G>A; p.G467G; 19:4548316-4548316	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1884G>A; p.R628R; 19:4544384-4544384	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.886G>A; p.G296R; 19:4552525-4552525	thyroid	carcinoma	Substitution - Missense
c.420G>C; p.T140T; 19:4556039-4556039	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.855C>T; p.F285F; 19:4552556-4552556	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.551C>T; p.A184V; 19:4555485-4555485	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1411C>A; p.L471I; 19:4548306-4548306	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.975C>A; p.S325S; 19:4552436-4552436	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.265G>C; p.E89Q; 19:4557204-4557204	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.178G>A; p.E60K; 19:4558093-4558093	skin	malignant_melanoma	Substitution - Missense
c.99G>A; p.P33P; 19:4558359-4558359	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1909G>A; p.E637K; 19:4544359-4544359	skin	malignant_melanoma	Substitution - Missense
c.1911G>A; p.E637E; 19:4544357-4544357	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.113C>A; p.P38H; 19:4558345-4558345	liver	carcinoma	Substitution - Missense
c.1574G>A; p.R525H; 19:4548054-4548054	bone; ilium	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1088C>T; p.T363M; 19:4550832-4550832	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1088C>T; p.T363M; 19:4550832-4550832	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.623G>T; p.R208L; 19:4555035-4555035	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.490G>A; p.V164I; 19:4555546-4555546	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.93G>A; p.P31P; 19:4558365-4558365	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1232C>A; p.S411*; 19:4550162-4550162	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1126G>A; p.G376R; 19:4550268-4550268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.261C>T; p.R87R; 19:4557208-4557208	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2661G>A; p.V887V; 19:4543607-4543607	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.926C>T; p.T309M; 19:4552485-4552485	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.138C>T; p.P46P; 19:4558133-4558133	skin	malignant_melanoma	Substitution - coding silent
c.138C>T; p.P46P; 19:4558133-4558133	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2475G>C; p.P825P; 19:4543793-4543793	liver	carcinoma	Substitution - coding silent
c.2475G>C; p.P825P; 19:4543793-4543793	liver	carcinoma	Substitution - coding silent
c.1872C>T; p.L624L; 19:4544396-4544396	skin	malignant_melanoma	Substitution - coding silent
c.515C>G; p.A172G; 19:4555521-4555521	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1513G>A; p.A505T; 19:4548115-4548115	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.388G>A; p.V130I; 19:4556071-4556071	central_nervous_system; brain	glioma	Substitution - Missense
c.1154A>T; p.Y385F; 19:4550240-4550240	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1219G>A; p.E407K; 19:4550175-4550175	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.580G>A; p.A194T; 19:4555078-4555078	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1215G>A; p.M405I; 19:4550179-4550179	skin	malignant_melanoma	Substitution - Missense
c.735C>A; p.F245L; 19:4554424-4554424	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1143delC; p.M383fs*22; 19:4550251-4550251	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1705G>A; p.G569R; 19:4546249-4546249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1526delG; p.G509fs*25; 19:4548102-4548102	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1419C>T; p.V473V; 19:4548298-4548298	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2305A>C; p.T769P; 19:4543963-4543963	pancreas	carcinoma	Substitution - Missense
c.1098G>A; p.P366P; 19:4550822-4550822	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1098G>A; p.P366P; 19:4550822-4550822	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.601G>A; p.A201T; 19:4555057-4555057	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1224G>A; p.A408A; 19:4550170-4550170	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1894C>T; p.R632W; 19:4544374-4544374	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.958G>A; p.V320I; 19:4552453-4552453	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1554G>T; p.V518V; 19:4548074-4548074	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.826delC; p.R276fs*11; 19:4552585-4552585	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1852G>A; p.V618M; 19:4544416-4544416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.826delC; p.R276fs*11; 19:4552585-4552585	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1140_1141CC>TT; p.P381S; 19:4550253-4550254	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2040G>A; p.L680L; 19:4544228-4544228	liver	carcinoma	Substitution - coding silent
c.274C>T; p.P92S; 19:4557195-4557195	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1133G>C; p.C378S; 19:4550261-4550261	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1768C>A; p.R590S; 19:4544500-4544500	liver	carcinoma	Substitution - Missense
c.1768C>A; p.R590S; 19:4544500-4544500	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.456G>T; p.V152V; 19:4556003-4556003	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1883G>A; p.R628Q; 19:4544385-4544385	skin	malignant_melanoma	Substitution - Missense
c.1009T>C; p.C337R; 19:4550911-4550911	central_nervous_system; brain	glioma	Substitution - Missense
c.1565C>A; p.P522H; 19:4548063-4548063	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1477G>A; p.E493K; 19:4548151-4548151	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1341G>T; p.L447L; 19:4548376-4548376	skin	malignant_melanoma	Substitution - coding silent
c.1281G>C; p.L427L; 19:4548436-4548436	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1119C>T; p.P373P; 19:4550801-4550801	skin	malignant_melanoma	Substitution - coding silent
c.553C>A; p.L185I; 19:4555483-4555483	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.737G>A; p.R246Q; 19:4554422-4554422	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.72C>T; p.H24H; 19:4558386-4558386	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.518G>A; p.R173H; 19:4555518-4555518	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1058G>A; p.R353Q; 19:4550862-4550862	skin	malignant_melanoma	Substitution - Missense
c.2554G>A; p.G852S; 19:4543714-4543714	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense

COSMIC somatic mutation [Top]