Entrez Gene

Basic Information
Gene ID	10488
Name	CREB3
Synonymous	cAMP responsive element binding protein 3;CREB3;cAMP responsive element binding protein 3
Definition	CREB-3\|basic leucine zipper protein\|cAMP-responsive element-binding protein 3\|cyclic AMP response element (CRE)-binding protein/activating transcription factor 1\|cyclic AMP-responsive element-binding protein 3\|leucin zipper proitein\|leucine zipper protein
Position	9p13.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.542G>A; p.R181K; 9:35735215-35735215	liver	carcinoma	Substitution - Missense
c.542G>A; p.R181K; 9:35735215-35735215	liver	carcinoma	Substitution - Missense
c.803C>T; p.A268V; 9:35736413-35736413	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.791G>A; p.R264H; 9:35736401-35736401	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.791G>A; p.R264H; 9:35736401-35736401	pancreas	carcinoma	Substitution - Missense
c.458G>A; p.R153H; 9:35735131-35735131	liver	carcinoma	Substitution - Missense
c.135G>A; p.P45P; 9:35733001-35733001	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.252A>C; p.P84P; 9:35733118-35733118	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011C>G; p.L337L; 9:35736621-35736621	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1091T>C; p.I364T; 9:35736701-35736701	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.159G>A; p.L53L; 9:35733025-35733025	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.674G>C; p.S225T; 9:35736110-35736110	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1016G>A; p.R339Q; 9:35736626-35736626	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.134C>G; p.P45R; 9:35733000-35733000	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.290G>A; p.C97Y; 9:35733227-35733227	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.274C>T; p.L92L; 9:35733140-35733140	skin	malignant_melanoma	Substitution - coding silent
c.648G>A; p.M216I; 9:35736084-35736084	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.819C>A; p.D273E; 9:35736429-35736429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1009C>A; p.L337I; 9:35736619-35736619	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.240C>G; p.T80T; 9:35733106-35733106	breast	carcinoma	Substitution - coding silent
c.465G>C; p.R155R; 9:35735138-35735138	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.174G>A; p.L58L; 9:35733040-35733040	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.681C>T; p.S227S; 9:35736117-35736117	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.506G>A; p.R169K; 9:35735179-35735179	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.506G>A; p.R169K; 9:35735179-35735179	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.671C>T; p.T224I; 9:35736107-35736107	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.46C>A; p.L16M; 9:35732818-35732818	breast	carcinoma	Substitution - Missense
c.499A>G; p.S167G; 9:35735172-35735172	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.641A>C; p.Q214P; 9:35736077-35736077	meninges	meningioma	Substitution - Missense
c.425C>G; p.P142R; 9:35733475-35733475	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.941A>G; p.Y314C; 9:35736551-35736551	liver	carcinoma	Substitution - Missense
c.941A>G; p.Y314C; 9:35736551-35736551	liver	carcinoma	Substitution - Missense
c.1062A>G; p.G354G; 9:35736672-35736672	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.805C>A; p.L269I; 9:35736415-35736415	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.810C>A; p.P270P; 9:35736420-35736420	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.983C>A; p.P328Q; 9:35736593-35736593	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.577C>T; p.Q193*; 9:35735340-35735340	skin	malignant_melanoma	Substitution - Nonsense
c.697-1G>A; p.?; 9:35736226-35736226	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.612G>A; p.L204L; 9:35736048-35736048	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.178delC; p.P61fs*4; 9:35733044-35733044	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.745T>C; p.S249P; 9:35736275-35736275	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.373_375delGAG; p.E125delE; 9:35733423-35733425	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.910G>C; p.A304P; 9:35736520-35736520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.373_375delGAG; p.E125delE; 9:35733423-35733425	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.871A>G; p.T291A; 9:35736481-35736481	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.475C>T; p.R159*; 9:35735148-35735148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.686C>G; p.T229S; 9:35736122-35736122	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.475C>T; p.R159*; 9:35735148-35735148	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.435+7_435+8delCT; p.?; 9:35733492-35733493	liver	carcinoma	Unknown
c.511A>G; p.K171E; 9:35735184-35735184	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1037A>C; p.Q346P; 9:35736647-35736647	central_nervous_system; brain	glioma	Substitution - Missense
c.772G>T; p.E258*; 9:35736302-35736302	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.709T>G; p.S237A; 9:35736239-35736239	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.511_513delAAG; p.K172delK; 9:35735184-35735186	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame

COSMIC somatic mutation [Top]