Entrez Gene

Basic Information
Gene ID	10457
Name	GPNMB
Synonymous	glycoprotein (transmembrane) nmb;GPNMB;glycoprotein (transmembrane) nmb
Definition	glycoprotein NMB\|glycoprotein nmb-like protein\|osteoactivin\|transmembrane glycoprotein HGFIN\|transmembrane glycoprotein NMB
Position	7p15
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.382G>T; p.A128S; 7:23256906-23256906	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.701-1G>T; p.?; 7:23260455-23260455	breast	carcinoma	Unknown
c.1351C>T; p.L451L; 7:23270061-23270061	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.181G>T; p.V61L; 7:23253417-23253417	thyroid	carcinoma	Substitution - Missense
c.735G>C; p.K245N; 7:23260490-23260490	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1668C>G; p.N556K; 7:23274173-23274173	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1153+8T>A; p.?; 7:23266623-23266623	liver	carcinoma	Unknown
c.1525A>G; p.I509V; 7:23273580-23273580	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1192G>A; p.V398I; 7:23267924-23267924	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.252T>C; p.S84S; 7:23254197-23254197	skin	malignant_melanoma	Substitution - coding silent
c.1192G>A; p.V398I; 7:23267924-23267924	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.612G>T; p.G204G; 7:23260050-23260050	pancreas	carcinoma	Substitution - coding silent
c.487C>T; p.P163S; 7:23257011-23257011	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1126C>A; p.H376N; 7:23266588-23266588	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1202C>T; p.P401L; 7:23267934-23267934	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1157G>T; p.G386V; 7:23267889-23267889	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1462A>G; p.R488G; 7:23270172-23270172	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1052C>T; p.P351L; 7:23266514-23266514	liver	carcinoma	Substitution - Missense
c.329C>T; p.A110V; 7:23254274-23254274	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.329C>T; p.A110V; 7:23254274-23254274	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1651G>A; p.V551M; 7:23274156-23274156	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.391T>C; p.Y131H; 7:23256915-23256915	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1661C>T; p.P554L; 7:23274166-23274166	pancreas	carcinoma	Substitution - Missense
c.463G>A; p.V155I; 7:23256987-23256987	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.481C>A; p.P161T; 7:23257005-23257005	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.940A>T; p.T314S; 7:23260695-23260695	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.604A>G; p.T202A; 7:23260042-23260042	liver	carcinoma	Substitution - Missense
c.445G>A; p.G149S; 7:23256969-23256969	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.445G>A; p.G149S; 7:23256969-23256969	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.532C>A; p.H178N; 7:23257056-23257056	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1466-2A>G; p.?; 7:23273519-23273519	urinary_tract; bladder	carcinoma	Unknown
c.1327C>T; p.P443S; 7:23270037-23270037	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.742C>A; p.R248R; 7:23260497-23260497	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.89G>C; p.G30A; 7:23253325-23253325	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1300G>A; p.E434K; 7:23270010-23270010	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1239C>T; p.V413V; 7:23267971-23267971	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.240G>A; p.A80A; 7:23254185-23254185	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1410G>A; p.L470L; 7:23270120-23270120	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.125A>C; p.N42T; 7:23253361-23253361	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.90C>A; p.G30G; 7:23253326-23253326	liver	carcinoma	Substitution - coding silent
c.1710A>G; p.G570G; 7:23274215-23274215	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.503G>C; p.W168S; 7:23257027-23257027	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1157G>C; p.G386A; 7:23267889-23267889	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1013C>A; p.S338Y; 7:23260768-23260768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1321T>C; p.C441R; 7:23270031-23270031	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.344T>A; p.V115D; 7:23254289-23254289	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.795C>G; p.V265V; 7:23260550-23260550	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.657A>G; p.A219A; 7:23260095-23260095	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.881C>T; p.S294F; 7:23260636-23260636	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.881C>T; p.S294F; 7:23260636-23260636	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>T; p.W168C; 7:23257028-23257028	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1633C>T; p.L545F; 7:23274138-23274138	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.323A>G; p.E108G; 7:23254268-23254268	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.522C>G; p.I174M; 7:23257046-23257046	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.323A>G; p.E108G; 7:23254268-23254268	liver	carcinoma	Substitution - Missense
c.1367G>T; p.R456L; 7:23270077-23270077	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.652C>T; p.R218W; 7:23260090-23260090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.898A>G; p.N300D; 7:23260653-23260653	breast	carcinoma	Substitution - Missense
c.194G>A; p.G65E; 7:23253430-23253430	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.239C>T; p.A80V; 7:23254184-23254184	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.239C>T; p.A80V; 7:23254184-23254184	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.133A>C; p.N45H; 7:23253369-23253369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.684T>G; p.D228E; 7:23260122-23260122	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.565C>T; p.R189*; 7:23260003-23260003	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1253G>A; p.G418E; 7:23267985-23267985	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.498C>T; p.P166P; 7:23257022-23257022	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.29T>G; p.F10C; 7:23246886-23246886	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.701-2A>C; p.?; 7:23260454-23260454	eye; uveal_tract	malignant_melanoma; spindle	Unknown
c.1191C>T; p.D397D; 7:23267923-23267923	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1191C>T; p.D397D; 7:23267923-23267923	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1191C>T; p.D397D; 7:23267923-23267923	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1191C>T; p.D397D; 7:23267923-23267923	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.76C>A; p.H26N; 7:23253312-23253312	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1237G>C; p.V413L; 7:23267969-23267969	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.779C>T; p.P260L; 7:23260534-23260534	breast	carcinoma	Substitution - Missense
c.1073C>A; p.P358H; 7:23266535-23266535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.145T>A; p.S49T; 7:23253381-23253381	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.329C>A; p.A110D; 7:23254274-23254274	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.654G>T; p.R218R; 7:23260092-23260092	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1172A>G; p.N391S; 7:23267904-23267904	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.906G>A; p.T302T; 7:23260661-23260661	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1172A>G; p.N391S; 7:23267904-23267904	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>C; p.D158H; 7:23256996-23256996	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1056A>G; p.G352G; 7:23266518-23266518	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.924C>T; p.T308T; 7:23260679-23260679	breast	carcinoma	Substitution - coding silent
c.296A>G; p.N99S; 7:23254241-23254241	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1348T>A; p.C450S; 7:23270058-23270058	liver	carcinoma	Substitution - Missense
c.499G>A; p.G167R; 7:23257023-23257023	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1708G>C; p.G570R; 7:23274213-23274213	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.822C>G; p.L274L; 7:23260577-23260577	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.856G>C; p.G286R; 7:23260611-23260611	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.390G>A; p.P130P; 7:23256914-23256914	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.390G>A; p.P130P; 7:23256914-23256914	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1635C>T; p.L545L; 7:23274140-23274140	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.587T>C; p.V196A; 7:23260025-23260025	pancreas	carcinoma	Substitution - Missense
c.1687C>A; p.L563I; 7:23274192-23274192	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.116G>C; p.R39T; 7:23253352-23253352	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.144T>G; p.S48S; 7:23253380-23253380	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.494A>C; p.H165P; 7:23257018-23257018	breast	carcinoma	Substitution - Missense
c.1669C>T; p.Q557*; 7:23274174-23274174	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1593T>C; p.S531S; 7:23274098-23274098	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.981A>G; p.P327P; 7:23260736-23260736	pancreas	carcinoma	Substitution - coding silent
c.1088G>A; p.R363K; 7:23266550-23266550	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.981A>G; p.P327P; 7:23260736-23260736	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.476G>T; p.G159V; 7:23257000-23257000	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.922A>G; p.T308A; 7:23260677-23260677	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.499G>T; p.G167*; 7:23257023-23257023	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1305C>G; p.I435M; 7:23270015-23270015	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.499G>T; p.G167*; 7:23257023-23257023	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1362G>C; p.V454V; 7:23270072-23270072	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1081C>T; p.L361L; 7:23266543-23266543	liver	carcinoma	Substitution - coding silent
c.1365A>G; p.R455R; 7:23270075-23270075	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1406C>T; p.T469I; 7:23270116-23270116	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1125C>T; p.G375G; 7:23266587-23266587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.64G>A; p.A22T; 7:23246921-23246921	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.64G>A; p.A22T; 7:23246921-23246921	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.64G>A; p.A22T; 7:23246921-23246921	breast	carcinoma	Substitution - Missense
c.49T>C; p.L17L; 7:23246906-23246906	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.963A>C; p.G321G; 7:23260718-23260718	thyroid	other; neoplasm	Substitution - coding silent
c.778C>T; p.P260S; 7:23260533-23260533	skin	malignant_melanoma	Substitution - Missense
c.1240G>A; p.V414M; 7:23267972-23267972	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.689A>T; p.Y230F; 7:23260127-23260127	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1686A>T; p.L562L; 7:23274191-23274191	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.743G>A; p.R248Q; 7:23260498-23260498	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.669C>T; p.I223I; 7:23260107-23260107	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.669C>T; p.I223I; 7:23260107-23260107	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.71-7G>A; p.?; 7:23253300-23253300	liver	carcinoma	Unknown
c.71-7G>A; p.?; 7:23253300-23253300	liver	carcinoma	Unknown
c.372_373insG; p.L126fs*4; 7:23256896-23256897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Insertion - Frameshift
c.1324A>C; p.S442R; 7:23270034-23270034	breast	carcinoma	Substitution - Missense
c.1329T>C; p.P443P; 7:23270039-23270039	breast	carcinoma	Substitution - coding silent
c.690C>T; p.Y230Y; 7:23260128-23260128	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.690C>T; p.Y230Y; 7:23260128-23260128	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.803A>G; p.H268R; 7:23260558-23260558	liver	carcinoma	Substitution - Missense
c.803A>G; p.H268R; 7:23260558-23260558	liver	carcinoma	Substitution - Missense
c.1265C>A; p.T422K; 7:23269975-23269975	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.501A>G; p.G167G; 7:23257025-23257025	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.457C>A; p.H153N; 7:23256981-23256981	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.502T>C; p.W168R; 7:23257026-23257026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.306C>T; p.F102F; 7:23254251-23254251	skin	malignant_melanoma	Substitution - coding silent
c.1592G>T; p.S531I; 7:23274097-23274097	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.472G>A; p.D158N; 7:23256996-23256996	urinary_tract; bladder	carcinoma	Substitution - Missense
c.591C>G; p.N197K; 7:23260029-23260029	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.21C>T; p.F7F; 7:23246878-23246878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.191G>A; p.R64Q; 7:23253427-23253427	skin	malignant_melanoma	Substitution - Missense
c.1060G>A; p.A354T; 7:23266522-23266522	thyroid	other; neoplasm	Substitution - Missense
c.1122T>C; p.Y374Y; 7:23266584-23266584	breast	carcinoma	Substitution - coding silent
c.701-6T>A; p.?; 7:23260450-23260450	endometrium	carcinoma; serous_carcinoma	Unknown
c.168A>C; p.E56D; 7:23253404-23253404	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1401C>A; p.N467K; 7:23270111-23270111	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1401C>A; p.N467K; 7:23270111-23270111	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.84G>T; p.V28V; 7:23253320-23253320	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.199A>G; p.M67V; 7:23253435-23253435	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.29T>A; p.F10Y; 7:23246886-23246886	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]