Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

10278

Name

EFS

Synonymous

embryonal Fyn-associated substrate;EFS;embryonal Fyn-associated substrate

Definition

Cas scaffolding protein family member 3|signal transduction protein (SH3 containing)

Position

14q11.2

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1081A>G; p.M361V; 14:23359397-23359397

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.207C>T; p.G69G; 14:23360645-23360645

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.727G>A; p.G243R; 14:23359751-23359751

 skinmalignant_melanomaSubstitution - Missense

c.1504G>A; p.A502T; 14:23357408-23357408

 skinmalignant_melanomaSubstitution - Missense

c.134G>A; p.G45D; 14:23360718-23360718

 central_nervous_system; brainglioma; astrocytoma_Grade_IISubstitution - Missense

c.1269G>A; p.G423G; 14:23357643-23357643

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.866C>T; p.P289L; 14:23359612-23359612

 pancreascarcinomaSubstitution - Missense

c.284A>G; p.N95S; 14:23360568-23360568

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.127C>T; p.L43L; 14:23360725-23360725

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.769C>T; p.L257L; 14:23359709-23359709

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.1237A>G; p.M413V; 14:23358890-23358890

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1424A>G; p.K475R; 14:23357488-23357488

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.297+10G>A; p.?; 14:23360545-23360545

 soft_tissue; blood_vesselangiosarcomaUnknown

c.677C>T; p.A226V; 14:23359801-23359801

 livercarcinomaSubstitution - Missense

c.677C>T; p.A226V; 14:23359801-23359801

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.677C>T; p.A226V; 14:23359801-23359801

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.677C>T; p.A226V; 14:23359801-23359801

 livercarcinomaSubstitution - Missense

c.319G>T; p.A107S; 14:23360260-23360260

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1028G>T; p.R343L; 14:23359450-23359450

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.529G>A; p.A177T; 14:23359949-23359949

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1286C>A; p.S429Y; 14:23357626-23357626

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1083G>A; p.M361I; 14:23359395-23359395

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.708C>A; p.P236P; 14:23359770-23359770

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.80G>T; p.R27L; 14:23360772-23360772

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.708C>A; p.P236P; 14:23359770-23359770

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.390C>T; p.I130I; 14:23360189-23360189

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1147T>C; p.Y383H; 14:23359331-23359331

 thyroidcarcinomaSubstitution - Missense

c.1627A>T; p.T543S; 14:23357285-23357285

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1245G>A; p.A415A; 14:23358882-23358882

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1578C>T; p.A526A; 14:23357334-23357334

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.444C>T; p.Y148Y; 14:23360034-23360034

 breastcarcinomaSubstitution - coding silent

c.391C>T; p.P131S; 14:23360188-23360188

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.18+1G>T; p.?; 14:23365007-23365007

 large_intestine; rectumcarcinoma; adenocarcinomaUnknown

c.1116C>T; p.Y372Y; 14:23359362-23359362

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.19A>G; p.T7A; 14:23360833-23360833

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1133C>A; p.A378D; 14:23359345-23359345

 parathyroidadenomaSubstitution - Missense

c.1201G>A; p.A401T; 14:23358926-23358926

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1617G>A; p.V539V; 14:23357295-23357295

 breastcarcinomaSubstitution - coding silent

c.1251G>T; p.Q417H; 14:23358876-23358876

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1017A>C; p.P339P; 14:23359461-23359461

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.1017A>C; p.P339P; 14:23359461-23359461

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1017A>C; p.P339P; 14:23359461-23359461

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1023A>C; p.P341P; 14:23359455-23359455

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.1023A>C; p.P341P; 14:23359455-23359455

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1023A>C; p.P341P; 14:23359455-23359455

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1023A>C; p.P341P; 14:23359455-23359455

 pancreascarcinomaSubstitution - coding silent

c.1023A>C; p.P341P; 14:23359455-23359455

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1023A>C; p.P341P; 14:23359455-23359455

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1402C>T; p.R468C; 14:23357510-23357510

 prostatecarcinomaSubstitution - Missense

c.1032G>A; p.L344L; 14:23359446-23359446

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.631G>A; p.E211K; 14:23359847-23359847

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1021C>A; p.P341T; 14:23359457-23359457

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.641C>T; p.P214L; 14:23359837-23359837

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.627C>T; p.G209G; 14:23359851-23359851

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1127C>T; p.P376L; 14:23359351-23359351

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1240C>T; p.P414S; 14:23358887-23358887

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.110G>T; p.R37I; 14:23360742-23360742

 skinmalignant_melanomaSubstitution - Missense

c.1386G>T; p.Q462H; 14:23357526-23357526

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.460G>A; p.A154T; 14:23360018-23360018

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.534G>A; p.P178P; 14:23359944-23359944

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1411G>A; p.V471M; 14:23357501-23357501

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.311C>T; p.P104L; 14:23360268-23360268

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.643C>A; p.P215T; 14:23359835-23359835

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1085A>G; p.E362G; 14:23359393-23359393

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1214A>G; p.D405G; 14:23358913-23358913

 lungcarcinoid-endocrine_tumour; typicalSubstitution - Missense

c.1045G>T; p.G349C; 14:23359433-23359433

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.132C>T; p.D44D; 14:23360720-23360720

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.25C>T; p.L9L; 14:23360827-23360827

 breastcarcinomaSubstitution - coding silent

c.1083G>T; p.M361I; 14:23359395-23359395

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1254G>A; p.E418E; 14:23357658-23357658

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.586_587CC>TT; p.P196L; 14:23359891-23359892

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.353G>A; p.G118E; 14:23360226-23360226

 skinmalignant_melanomaSubstitution - Missense

c.523C>T; p.R175W; 14:23359955-23359955

 thyroidother; neoplasmSubstitution - Missense

c.523C>T; p.R175W; 14:23359955-23359955

 breastcarcinomaSubstitution - Missense

c.523C>T; p.R175W; 14:23359955-23359955

 breastcarcinomaSubstitution - Missense

c.359G>T; p.C120F; 14:23360220-23360220

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1624G>T; p.V542L; 14:23357288-23357288

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1519G>T; p.A507S; 14:23357393-23357393

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.326C>T; p.P109L; 14:23360253-23360253

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1242G>A; p.P414P; 14:23358885-23358885

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1142A>G; p.Y381C; 14:23359336-23359336

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.445G>A; p.D149N; 14:23360033-23360033

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.289G>T; p.D97Y; 14:23360563-23360563

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.376C>A; p.L126I; 14:23360203-23360203

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.673C>T; p.R225*; 14:23359805-23359805

 prostatecarcinomaSubstitution - Nonsense

c.673C>T; p.R225*; 14:23359805-23359805

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.748G>A; p.E250K; 14:23359730-23359730

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.1547G>A; p.R516Q; 14:23357365-23357365

 pancreasother; adenomaSubstitution - Missense

c.748G>A; p.E250K; 14:23359730-23359730

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.964C>T; p.P322S; 14:23359514-23359514

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.736G>T; p.G246W; 14:23359742-23359742

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1091A>C; p.D364A; 14:23359387-23359387

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1299G>A; p.L433L; 14:23357613-23357613

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1611G>T; p.E537D; 14:23357301-23357301

 pancreascarcinomaSubstitution - Missense

c.860G>T; p.S287I; 14:23359618-23359618

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1028G>A; p.R343H; 14:23359450-23359450

 skinmalignant_melanomaSubstitution - Missense

c.1323G>A; p.G441G; 14:23357589-23357589

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1615G>T; p.V539L; 14:23357297-23357297

 pancreascarcinomaSubstitution - Missense

c.1640G>T; p.G547V; 14:23357272-23357272

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.690C>G; p.L230L; 14:23359788-23359788

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1329C>T; p.C443C; 14:23357583-23357583

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.178G>A; p.A60T; 14:23360674-23360674

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.144C>T; p.L48L; 14:23360708-23360708

 skinmalignant_melanomaSubstitution - coding silent

c.1549G>T; p.A517S; 14:23357363-23357363

 thyroidcarcinomaSubstitution - Missense

c.520A>G; p.T174A; 14:23359958-23359958

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense