Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

10054

Name

UBA2

Synonymous

ubiquitin-like modifier activating enzyme 2;UBA2;ubiquitin-like modifier activating enzyme 2

Definition

SUMO-1 activating enzyme subunit 2|SUMO-activating enzyme subunit 2|SUMO1 activating enzyme subunit 2|UBA2, ubiquitin-activating enzyme E1 homolog|anthracycline-associated resistance ARX|ubiquitin-like 1-activating enzyme E1B|ubiquitin-like modifier-activ

Position

19q12

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1405G>T; p.V469L; 19:34460473-34460473

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.495G>A; p.P165P; 19:34438680-34438680

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1370A>C; p.H457P; 19:34458893-34458893

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.495G>A; p.P165P; 19:34438680-34438680

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.495G>A; p.P165P; 19:34438680-34438680

 central_nervous_system; braingliomaSubstitution - coding silent

c.495G>A; p.P165P; 19:34438680-34438680

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.495G>A; p.P165P; 19:34438680-34438680

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.265A>G; p.I89V; 19:34431903-34431903

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.212C>G; p.S71*; 19:34430649-34430649

 skinmalignant_melanomaSubstitution - Nonsense

c.882G>A; p.T294T; 19:34451991-34451991

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.882G>A; p.T294T; 19:34451991-34451991

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.882G>A; p.T294T; 19:34451991-34451991

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1821G>T; p.E607D; 19:34469119-34469119

 livercarcinomaSubstitution - Missense

c.1821G>T; p.E607D; 19:34469119-34469119

 livercarcinomaSubstitution - Missense

c.1264C>T; p.P422S; 19:34458787-34458787

 skinmalignant_melanomaSubstitution - Missense

c.1128C>A; p.I376I; 19:34454349-34454349

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.796C>A; p.L266M; 19:34450289-34450289

 breastcarcinomaSubstitution - Missense

c.28G>A; p.E10K; 19:34428460-34428460

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1775C>T; p.S592L; 19:34469073-34469073

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1622A>T; p.D541V; 19:34466895-34466895

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1807G>A; p.V603I; 19:34469105-34469105

 pancreascarcinomaSubstitution - Missense

c.150T>G; p.D50E; 19:34430587-34430587

 haematopoietic_and_lymphoid_tissue; central_nervous_systemlymphoid_neoplasm; primary_central_nervous_system_lymphomaSubstitution - Missense

c.223-2A>T; p.?; 19:34431859-34431859

 endometriumcarcinoma; serous_carcinomaUnknown

c.1206A>T; p.G402G; 19:34454517-34454517

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1775C>A; p.S592*; 19:34469073-34469073

 livercarcinomaSubstitution - Nonsense

c.1775C>A; p.S592*; 19:34469073-34469073

 livercarcinomaSubstitution - Nonsense

c.1443A>C; p.Q481H; 19:34460511-34460511

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.75G>A; p.A25A; 19:34428507-34428507

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1717G>A; p.G573R; 19:34466990-34466990

 livercarcinomaSubstitution - Missense

c.226G>A; p.A76T; 19:34431864-34431864

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1717G>A; p.G573R; 19:34466990-34466990

 livercarcinomaSubstitution - Missense

c.139A>G; p.I47V; 19:34430576-34430576

 livercarcinomaSubstitution - Missense

c.667G>A; p.E223K; 19:34445017-34445017

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.667G>A; p.E223K; 19:34445017-34445017

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.347T>C; p.L116S; 19:34433401-34433401

 endometriumcarcinoma; serous_carcinomaSubstitution - Missense

c.1711G>A; p.D571N; 19:34466984-34466984

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.603T>C; p.D201D; 19:34443865-34443865

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1778A>C; p.D593A; 19:34469076-34469076

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1809C>T; p.V603V; 19:34469107-34469107

 breastcarcinomaSubstitution - coding silent

c.225T>C; p.V75V; 19:34431863-34431863

 bone; extraskeletalEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.696T>C; p.D232D; 19:34445046-34445046

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1869G>T; p.K623N; 19:34469167-34469167

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.709C>T; p.R237C; 19:34445059-34445059

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.690T>C; p.N230N; 19:34445040-34445040

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1547G>A; p.R516Q; 19:34464074-34464074

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.690T>C; p.N230N; 19:34445040-34445040

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1772A>C; p.D591A; 19:34469070-34469070

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.558C>T; p.I186I; 19:34438743-34438743

 skinmalignant_melanomaSubstitution - coding silent

c.748G>T; p.D250Y; 19:34445098-34445098

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.995A>G; p.H332R; 19:34452104-34452104

 livercarcinomaSubstitution - Missense

c.1718G>T; p.G573V; 19:34466991-34466991

 livercarcinomaSubstitution - Missense

c.1718G>T; p.G573V; 19:34466991-34466991

 livercarcinomaSubstitution - Missense

c.488C>T; p.P163L; 19:34438673-34438673

 skinmalignant_melanomaSubstitution - Missense

c.637C>T; p.P213S; 19:34443899-34443899

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1144A>G; p.N382D; 19:34454455-34454455

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.320G>A; p.R107Q; 19:34433374-34433374

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1168A>T; p.T390S; 19:34454479-34454479

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.871G>T; p.G291*; 19:34450364-34450364

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.71G>T; p.G24V; 19:34428503-34428503

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.620C>A; p.S207Y; 19:34443882-34443882

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.143A>T; p.D48V; 19:34430580-34430580

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemiaSubstitution - Missense

c.1105A>G; p.N369D; 19:34454326-34454326

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1267A>C; p.N423H; 19:34458790-34458790

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.495G>C; p.P165P; 19:34438680-34438680

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.710G>A; p.R237H; 19:34445060-34445060

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.931C>T; p.Q311*; 19:34452040-34452040

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1299A>G; p.A433A; 19:34458822-34458822

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1447G>A; p.E483K; 19:34460515-34460515

 breastcarcinomaSubstitution - Missense

c.319C>T; p.R107*; 19:34433373-34433373

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Nonsense

c.1265C>G; p.P422R; 19:34458788-34458788

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.114C>T; p.L38L; 19:34428546-34428546

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.69delG; p.A25fs*22; 19:34428501-34428501

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.526C>T; p.R176C; 19:34438711-34438711

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.526C>T; p.R176C; 19:34438711-34438711

 breastcarcinomaSubstitution - Missense

c.54C>G; p.G18G; 19:34428486-34428486

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.979G>A; p.E327K; 19:34452088-34452088

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.488C>A; p.P163H; 19:34438673-34438673

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1403T>C; p.I468T; 19:34460471-34460471

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1118G>C; p.R373T; 19:34454339-34454339

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.805A>G; p.M269V; 19:34450298-34450298

 pancreascarcinomaSubstitution - Missense

c.805A>G; p.M269V; 19:34450298-34450298

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.819G>A; p.W273*; 19:34450312-34450312

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1133-6T>C; p.?; 19:34454438-34454438

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.1246-1G>T; p.?; 19:34458768-34458768

 ovarycarcinoma; serous_carcinomaUnknown

c.1596C>G; p.I532M; 19:34464123-34464123

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.623C>T; p.P208L; 19:34443885-34443885

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.1113G>T; p.K371N; 19:34454334-34454334

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.84C>T; p.I28I; 19:34428516-34428516

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.54C>T; p.G18G; 19:34428486-34428486

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.740C>A; p.T247N; 19:34445090-34445090

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.222G>T; p.Q74H; 19:34430659-34430659

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.820C>T; p.R274W; 19:34450313-34450313

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1247_1248insT; p.L418fs*3; 19:34458770-34458771

 stomachcarcinoma; intestinal_adenocarcinomaInsertion - Frameshift

c.214A>C; p.K72Q; 19:34430651-34430651

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.214A>C; p.K72Q; 19:34430651-34430651

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1246-1G>C; p.?; 19:34458768-34458768

 central_nervous_system; thalamusglioma; oligodendroglioma_Grade_IIIUnknown

c.1702A>T; p.N568Y; 19:34466975-34466975

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.841_842CC>TT; p.P281L; 19:34450334-34450335

 skinmalignant_melanomaSubstitution - Missense

c.684A>C; p.A228A; 19:34445034-34445034

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1637T>G; p.V546G; 19:34466910-34466910

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1887G>A; p.Q629Q; 19:34469185-34469185

 pancreascarcinomaSubstitution - coding silent

c.1829G>A; p.R610H; 19:34469127-34469127

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.781G>T; p.D261Y; 19:34450274-34450274

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1829G>A; p.R610H; 19:34469127-34469127

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1829G>A; p.R610H; 19:34469127-34469127

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1652C>T; p.P551L; 19:34466925-34466925

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1652C>T; p.P551L; 19:34466925-34466925

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1788T>C; p.D596D; 19:34469086-34469086

 skinmalignant_melanomaSubstitution - coding silent

c.365G>A; p.R122Q; 19:34434874-34434874

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense