| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 843 |
Name | CASP10 |
Synonym | ALPS2|FLICE2|MCH4;caspase 10, apoptosis-related cysteine peptidase;CASP10;caspase 10, apoptosis-related cysteine peptidase |
Definition | CASP-10|FADD-like ICE2|FAS-associated death domain protein interleukin-1B-converting enzyme 2|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10, apoptosis-related cysteine protease|caspase-10|interleukin-1B-converting enzyme 2 |
Position | 2q33-q34 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Death Receptor Signalling;PID Reactome;500254 |
Pathway | TRAIL signaling;PID Reactome;500257 |
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | fas signaling pathway (cd95);PID BioCarta;100167 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | induction of apoptosis through dr3 and dr4/5 death receptors;PID BioCarta;100189 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | FasL/ CD95L signaling;PID Reactome;500255 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | caspase cascade in apoptosis;PID BioCarta;100218 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Disease | Embryoma;FunDO |
Disease | Autoimmune lymphoproliferative syndrome, type II;OMIM |
Disease | Diabetes mellitus;FunDO |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Rheumatoid arthritis;FunDO |
Disease | Gastric cancer, somatic;OMIM |
Disease | Non-Hodgkin lymphoma, somatic;OMIM |
Disease | Autoimmune lymphoproliferative syndromes;KEGG DISEASE;H00108 |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Neoplasm metastasis;FunDO |
External Links | |
Links to Entrez Gene | 843 |
Links to all GeneRIF Items | 843 |
Links to iHOP | 843 |
Sequence Information | |
Nucleotide Sequence | >843 : length: 5906 AAGGAAATGGAGATCCAAAGGAAAGCCTGAAGCACTTTGTGGCTTCCACGGGTTCGTTTC TAGGAAGCTTTTGCTTTACCTGGGGAAACCCCAAGCTCTACAGTGAGAAAGTTGTAAATT AGCCTTTAGGAGACGCTGTTTGTCAAAGTTATCTTAACCCTGGAAAAGGGGAGGGAAAAA GGCAGATAAGCAGTGATGACATCAGCAGGAAACTAGTATCAGGCTACCCAGTCCTGAAGA TTCAGTTTTCACTTAAACAACCAGCAAGTCTTGAAGTCTCTTCCCAAGCAAATGGGAGCT TCTTTGGACCTTGGAGCACACAGAGGATTCTACTTTCTTTAAAACTTTGTTTTCAGGCAA TTTCCCTGAGAACCGTTTACTTCCAGAAGATTGGTGGAGCTTGATCTGAAGGCTGGCCAT GAAATCTCAAGGTCAACATTGGTATTCCAGTTCAGATAAAAACTGTAAAGTGAGCTTTCG TGAGAAGCTTCTGATTATTGATTCAAACCTGGGGGTCCAAGATGTGGAGAACCTCAAGTT TCTCTGCATAGGATTGGTCCCCAACAAGAAGCTGGAGAAGTCCAGCTCAGCCTCAGATGT TTTTGAACATCTCTTGGCAGAGGATCTGCTGAGTGAGGAAGACCCTTTCTTCCTGGCAGA ACTCCTCTATATCATACGGCAGAAGAAGCTGCTGCAGCACCTCAACTGTACCAAAGAGGA AGTGGAGCGACTGCTGCCCACCCGACAAAGGGTTTCTCTGTTTAGAAACCTGCTCTACGA ACTGTCAGAAGGCATTGACTCAGAGAACTTAAAGGACATGATCTTCCTTCTGAAAGACTC GCTTCCCAAAACTGAAATGACCTCCCTAAGTTTCCTGGCATTTCTAGAGAAACAAGGTAA AATAGATGAAGATAATCTGACATGCCTGGAGGACCTCTGCAAAACAGTTGTACCTAAACT TTTGAGAAACATAGAGAAATACAAAAGAGAGAAAGCTATCCAGATAGTGACACCTCCTGT AGACAAGGAAGCCGAGTCGTATCAAGGAGAGGAAGAACTAGTTTCCCAAACAGATGTTAA GACATTCTTGGAAGCCTTACCGCAGGAGTCCTGGCAAAATAAGCATGCAGGTAGTAATGG TAACAGAGCCACAAATGGTGCACCAAGCCTGGTCTCCAGGGGGATGCAAGGAGCATCTGC TAACACTCTAAACTCTGAAACCAGCACAAAGAGGGCAGCTGTGTACAGGATGAATCGGAA CCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTTACCTCCCTGAAGGACAGACA AGGAACCCATAAAGATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGT GCATATACACAATAATGTGACGAAAGTGGAAATGGAGATGGTCCTGCAGAAGCAGAAGTG CAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATT TGGAGCTGTCTACTCTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTT CACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAACTCTTTTTCATCCAGGCCTG CCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCA GGCACCCACTTCCCTGCAGGACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGC CACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCAGCTGGTATATTCAGTC TCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCAC TGCTGTCAACGATGATGTGAGTCGAAGAGTGGACAAACAGGGAACAAAGAAACAGATGCC CCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGCCCCTGGATGCACTTTC ATTATAGCAGAGAGTTTTTGTTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTC CAGCCTCCTGCCCAGCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAAC ACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTTGCAAGTCTAAATGTTA GAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCACCCAGACTGGAGTGCAGGGGG GCAATCACGGCTCACTGTAGTCTCGACCTCCCAGGCTCAAGCTGTCCTCCCGCCTCAGCT TCCCAAGTAGCTGGGACCACAGGTGTGTACCACCGTGCCCGGATTTTTTTTATTCTTTAT TTTTTGTAGAGATGGAGGGATCTCACTTTGTTGCACAGGCTGGTTTCAAACTCCTAGGCC CAAGTGATCCTCCCACCTCTGTCCCCAAAATACTGGGATTATAGGCACGAGCCACCACAC CTGGCCAGAAAACTTTCATTATTGAAGACTTGGATTGTAGCCTTGGTTTTGGATGTCTAT TCTGAAGACAGAGTAATTGGCTTTGGTTTGTGCAGGTACTTTTTCTTTGAGACAGAGTCA CTCCGTCACCTGGGCTGGAGTGCAGTGGTGGGATCACTGTTCACTGCAGCCTTGACCTCC CAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAGACTACAGGTGTGTGTC CATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGC TGGTCTCAAACTCCTGGGCTCAAGCGATCCTCCCACCTCAGCTTCTCAAAGTTCTGGGAC TACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATTTTAAGGTTCCTTGGTG TTCAAAAACCACGTTCTTAGCCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCC TTAGTTATAATTCTGTGTCCCCTCTGCATGCCCTTAAACATTGGACAGTGAGGTCACAGT CCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTTTTGCACATCTAGTGAG GTGAAAATTTGGTCTATGCCAGGCCCATTTCCTGCTTTTGTGTAAGGAAGGTGCTCACAT AGGAAGTTTTTATTTGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACA CTCAGCTGCTCTGCAAGCAGAAACTTTACAACCTGATGTCATATTCCATTTTGGACTGGG TGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGGCAGATCACTTG AGGTCAGGAGTTCGAGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACA CAAAAATTAGCCAGGTGTGGCGGCGAGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGA CAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGC ACTCCAGCTTGGGCAACAGGGCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTG GAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGACTGAAGCAAAGAAGGGA ATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCT TGAATCAGGACTCAATCTACAGGCCAGCACCTTTCTCTTGGCCGGATGTCCTCAGGGCTG GCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTGCTACTACACTTTGCTC CTCTGGCCCAAGGCATGAGGAGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCA CTGGGCTCTTCTTGGCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGGCTCTGTAAGGA CGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTACTTGAGCTTTTTTTTT TTTTTTTTTCAATTTCTAGAGGAACTTTTTCTCTGTTAATTCCTGGAACTGTATTTTGAA TCCTTAAAGGTGAGCCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTAT AGATGAGGCAGCTGAGGCCTGGGGATGTGAACAACCTGCTCACAGTCCTCATTTACTGGA TTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCATTAGGAGTGTTT CATTTGATATGTGAATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGT GGTGCCTGCATTTATAATTATTTATGTGAAAGTCAAATTCATGTACAGTAAATTTGTTAT AAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAG CTTGACAGAGGGAATGTCTAATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAA ACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAGCCTCATGCATTTCAAGGAAATCACTT CTTTTCTAACAGCGAGCAGCCAGAAAGAGAAGAGAGTAAAATACAGATAAGACAGCTCTG GCATAGAGGGAGGTGGGGGGGTGGGGGAAGTCTCTTGGGTAACTGCCAAACTTTGCCTTC ATACAATGGGTTCCAGGAAAACAATGAGCCTTAATAAGCACATTCCTTTCCCTTCAGGTG CACTAAGTGGGGAAGCTAAAAGCAGACTGGAGGGGGGTGGGGTGTACCTACAGCTGCAGA AATATTGTATGGGAACGGACACACAACTCTCCCTCCCAGATAAGCACAGCAAAGAGACAT AGAAGCAATCCAAGCCTCTGATAAACTCTCCCACCCTAAATCCTTAAAAACTCTTAGTCT GTAAGTGAGTGGGCTCTGACCTAACTCGGCCAGAAGCCCCTTTCAAATTTGTTTTCTCTA AAATAAACCTGTCCTTGGCTGTCAAGCCACCTTTCATGTTTCTTTCCTCTTTCTTTAATT CTTACACATGTGTCAGGATGATCTCCCAAAACCGTGTTCATAACAGTCAGGGCCAAAAGC TAGTGGTCACAGTCCTTGTCCAGTTGGCAGAACTGACATGTGAAGGCAAGTGAAGGATGG TGAGATACTGAGGAAAGAGCAAAGGATCTGGAGATCAAAGCCCTGCATTTCCATTTTGTC CTGATTCCTTTGCTCAGAGACACTAACTAAATCAAGCTAGCTTTTTTCAGCCTTGTCTGT AAAGTAGAGAAAACATTAGCTGTTGGGAAGACGAAAAAGAATGTGTCCTATGTGTGCATC TATTTAAATCTAACTGTGCTGAGGTGCATATAAATGCCTTTAGGTGGTAGGGTCTTCCGG TTGTAACTGCAACAGAAATAGCAGGACTTAAGTTCCTTTGTGCGTAATTCCAGCTGACTT TATTAGCGGCAACTCAGCACTAGCATTACCCCTGACATACTCTGAGTAAGATCTAATTCT TCCCTCACTGGTTCGTGATGTCTACCGCAGCAGAAGGCCAGCTCTTGACTCTGAGTTCAG TTGGACAAAATGCTGTTGATAAAACCTCCTGTCAGGCCTCTGAGCCCAAGCTAAGCCATC ATATCCCTTGTGACCTGCACATATATATCCAGATGGCCTGAAGTAACTGAAGAATCACAA AAGAAGTGAAAATGGCCTGTTCCTGCCTTAACTGATGACATTACCTTGTGAAATTCCTTC TCCTGGCTCATCCTGGCTCAAAAGCTCCCCCAGTGAGCACCTTGTGACCCCCATCCCTGC CAGCCAGAGAACAACCCCCTTTGACTGTAATTTTCCACTACTTACCCAAATCCTATAAAA CGGCCCCACCCCTATCTCCCTTCACTGACTTTCTTTTCGGACTCAGCCCACCTGCACCCA GGTGATTAAAAAGCTTTATTGCTCAC |
Protein Sequence | >843 : length: 522 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSIL TAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL |