| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7297 |
Name | TYK2 |
Synonym | IMD35|JTK1;tyrosine kinase 2;TYK2;tyrosine kinase 2 |
Definition | non-receptor tyrosine-protein kinase TYK2 |
Position | 19p13.2 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | no2-dependent il-12 pathway in nk cells;PID BioCarta;100093 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | IL27-mediated signaling events;PID Curated;200023 |
Pathway | il22 soluble receptor signaling pathway;PID BioCarta;100131 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | il12 and stat4 dependent signaling pathway in th1 development;PID BioCarta;100133 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | ifn alpha signaling pathway;PID BioCarta;100139 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | stat3 signaling pathway;PID BioCarta;100028 |
Disease | Autoimmune disease;FunDO |
Disease | Lupus erythematosus;FunDO |
Disease | Other well-defined immunodeficiency syndromes;KEGG DISEASE;H00107 |
Disease | Type 1 diabetes;NHGRI |
Disease | Prostate cancer;FunDO |
Disease | Thrombocythemia, Hemorrhagic;FunDO |
Disease | type 1 diabetes;GAD |
Disease | IMMUNE;GAD |
Disease | Immune system diseases;KEGG DISEASE |
Disease | lupus erythematosus;GAD |
Disease | Sarcoidosis;FunDO |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Tyrosine kinase 2 deficiency;OMIM |
External Links | |
Links to Entrez Gene | 7297 |
Links to all GeneRIF Items | 7297 |
Links to iHOP | 7297 |
Sequence Information | |
Nucleotide Sequence | >7297 : length: 4262 AAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGA AGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCG CGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACT GCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACA ACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCC CAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCT GAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCC GTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGG GCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAG GAAGTCTGCATCCACATTGCACATAAAGTTGGTATCACTCCTCCTTGCTTCAATCTCTTT GCCCTCTTCGATGCTCAGGCCCAAGTCTGGTTGCCCCCAAACCACATCCTAGAGATCCCC AGAGATGCAAGCCTGATGCTATATTTCCGCATAAGGTTTTATTTCCGGAACTGGCATGGC ATGAATCCTCGGGAACCGGCTGTGTACCGTTGTGGGCCCCCAGGAACCGAGGCATCCTCA GATCAGACAGCACAGGGGATGCAACTCCTGGACCCAGCCTCATTTGAGTACCTCTTTGAG CAGGGCAAGCATGAGTTTGTGAATGACGTGGCATCACTGTGGGAGCTGTCGACCGAGGAG GAGATCCACCACTTTAAGAATGAGAGCCTGGGCATGGCCTTTCTGCACCTCTGTCACCTC GCTCTCCGCCATGGCATCCCCCTGGAGGAGGTGGCCAAGAAGACCAGCTTCAAGGACTGC ATCCCGCGCTCCTTCCGCCGGCATATCCGGCAGCACAGCGCCCTGACCCGGCTGCGCCTT CGGAACGTCTTCCGCAGGTTCCTGCGGGACTTCCAGCCGGGCCGACTCTCCCAGCAGATG GTCATGGTCAAATACCTAGCCACACTCGAGCGGCTGGCACCCCGCTTCGGCACAGAGCGT GTGCCCGTGTGCCACCTGAGGCTGCTGGCCCAGGCCGAGGGGGAGCCCTGCTACATCCGG GACAGTGGGGTGGCCCCTACAGACCCTGGCCCTGAGTCTGCTGCTGGGCCCCCAACCCAC GAGGTGCTGGTGACAGGCACTGGTGGCATCCAGTGGTGGCCAGTAGAGGAGGAGGTGAAC AAGGAGGAGGGTTCTAGTGGCAGCAGTGGCAGGAACCCCCAAGCCAGCCTGTTTGGGAAG AAGGCCAAGGCTCACAAGGCAGTCGGCCAGCCGGCAGACAGGCCGCGGGAGCCACTGTGG GCCTACTTCTGTGACTTCCGGGACATCACCCACGTGGTGCTGAAAGAGCACTGTGTCAGC ATCCACCGGCAGGACAACAAGTGCCTGGAGCTGAGCTTGCCTTCCCGGGCTGCGGCGCTG TCCTTCGTGTCGCTGGTGGACGGCTATTTCCGCCTGACGGCCGACTCCAGCCACTACCTG TGCCACGAGGTGGCTCCCCCACGGCTGGTGATGAGCATCCGGGATGGGATCCACGGACCC CTGCTGGAGCCATTTGTGCAGGCCAAGCTGCGGCCCGAGGACGGCCTGTACCTCATTCAC TGGAGCACCAGCCACCCCTACCGCCTGATCCTCACAGTGGCCCAGCGTAGCCAGGCACCA GACGGCATGCAGAGCTTGCGGCTCCGAAAGTTCCCCATTGAGCAGCAGGACGGGGCCTTC GTGCTGGAGGGCTGGGGCCGGTCCTTCCCCAGCGTTCGGGAACTTGGGGCTGCCTTGCAG GGCTGCTTGCTGAGGGCCGGGGATGACTGCTTCTCTCTGCGTCGCTGTTGCCTGCCCCAA CCAGGAGAAACCTCCAATCTCATCATCATGCGGGGGGCTCGGGCCAGCCCCAGGACACTC AACCTCAGCCAGCTCAGCTTCCACCGGGTTGACCAGAAGGAGATCACCCAGCTGTCCCAC TTGGGCCAGGGCACAAGGACCAACGTGTATGAGGGCCGCCTGCGAGTGGAGGGCAGCGGG GACCCTGAGGAGGGCAAGATGGATGACGAGGACCCCCTCGTGCCTGGCAGGGACCGTGGG CAGGAGCTACGAGTGGTGCTCAAAGTGCTGGACCCTAGTCACCATGACATCGCCCTGGCC TTCTACGAGACAGCCAGCCTCATGAGCCAGGTCTCCCACACGCACCTGGCCTTCGTGCAT GGCGTCTGTGTGCGCGGCCCTGAAAATATCATGGTGACAGAGTACGTGGAGCACGGACCC CTGGATGTGTGGCTGCGGAGGGAGCGGGGCCATGTGCCCATGGCTTGGAAGATGGTGGTG GCCCAGCAGCTGGCCAGCGCCCTCAGCTACCTGGAGAACAAGAACCTGGTTCATGGTAAT GTGTGTGGCCGGAACATCCTGCTGGCCCGGCTGGGGTTGGCAGAGGGCACCAGCCCCTTC ATCAAGCTGAGTGATCCTGGCGTGGGCCTGGGCGCCCTCTCCAGGGAGGAGCGGGTGGAG AGGATCCCCTGGCTGGCCCCCGAATGCCTACCAGGTGGGGCCAACAGCCTAAGCACCGCC ATGGACAAGTGGGGGTTTGGCGCCACCCTCCTGGAGATCTGCTTTGACGGAGAGGCCCCT CTGCAGAGCCGCAGTCCCTCCGAGAAGGAGCATTTCTACCAGAGGCAGCACCGGCTGCCC GAGCCCTCCTGCCCACAGCTGGCCACACTCACCAGCCAGTGTCTGACCTATGAGCCAACC CAGAGGCCATCATTCCGCACCATCCTGCGTGACCTCACCCGGCTGCAGCCCCACAATCTT GCTGACGTCTTGACTGTGAACCCGGACTCACCGGCGTCGGACCCTACGGTTTTCCACAAG CGCTATTTGAAAAAGATCCGAGATCTGGGCGAGGGTCACTTCGGCAAGGTCAGCTTGTAC TGCTACGATCCGACCAACGACGGCACTGGCGAGATGGTGGCGGTGAAAGCCCTCAAGGCA GACTGCGGCCCCCAGCACCGCTCGGGCTGGAAGCAGGAGATTGACATTCTGCGCACGCTC TACCACGAGCACATCATCAAGTACAAGGGCTGCTGCGAGGACCAAGGCGAGAAGTCGCTG CAGCTGGTCATGGAGTACGTGCCCCTGGGCAGCCTCCGAGACTACCTGCCCCGGCACAGC ATCGGGCTGGCCCAGCTGCTGCTCTTCGCCCAGCAGATCTGCGAGGGCATGGCCTATCTG CACGCGCAGCACTACATCCACCGAGACCTAGCCGCGCGCAACGTGCTGCTGGACAACGAC AGGCTGGTCAAGATCGGGGACTTTGGCCTAGCCAAGGCCGTGCCCGAAGGCCACGAGTAC TACCGCGTGCGCGAGGATGGGGACAGCCCCGTGTTCTGGTATGCCCCAGAGTGCCTGAAG GAGTATAAGTTCTACTATGCGTCAGATGTCTGGTCCTTCGGGGTGACCCTGTATGAGCTG CTGACGCACTGTGACTCCAGCCAGAGCCCCCCCACGAAATTCCTTGAGCTCATAGGCATT GCTCAGGGTCAGATGACAGTTCTGAGACTCACTGAGTTGCTGGAACGAGGGGAGAGGCTG CCACGGCCCGACAAATGTCCCTGTGAGGTCTATCATCTCATGAAGAACTGCTGGGAGACA GAGGCGTCCTTTCGCCCAACCTTCGAGAACCTCATACCCATTCTGAAGACAGTCCATGAG AAGTACCAAGGCCAGGCCCCTTCAGTGTTCAGCGTGTGCTGAGGCACAATGGCAGCCCTG CCTGGGAGGACTGGACCAGGCAGTGGCTGCAGAGGGAGCCTCCTGCTCCCTGCTCCAGGA TGAAACCAAGAGGGGGATGTCAGCCTCACCCACACCGTGTGCCTTACTCCTGTCTAGAGA CCCCACCTCTGTGAACTTATTTTTCTTTCTTGGCCGTGAGCCTAACCATGATCTTGAGGG ACCCAACATTTGTAGGGGCACTAATCCAGCCCTTAAATCCCCCAGCTTCCAAACTTGAGG CCCACCATCTCCACCATCTGGTAATAAACTCATGTTTTCTCTGCTGGAAAAAAAAAAAAA AA |
Protein Sequence | >7297 : length: 1187 MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC |