| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6934 |
Name | TCF7L2 |
Synonym | TCF-4|TCF4;transcription factor 7-like 2 (T-cell specific, HMG-box);TCF7L2;transcription factor 7-like 2 (T-cell specific, HMG-box) |
Definition | HMG box transcription factor 4|T-cell factor 4|T-cell factor-4 variant A|T-cell factor-4 variant B|T-cell factor-4 variant C|T-cell factor-4 variant D|T-cell factor-4 variant E|T-cell factor-4 variant F|T-cell factor-4 variant G|T-cell factor-4 variant H| |
Position | 10q25.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | AP-1 transcription factor network;PID Curated;200118 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Type 2 diabetes;NHGRI |
Disease | fasting glucose-related traits;GAD |
Disease | diabetes, gestational;GAD |
Disease | body mass insulin;GAD |
Disease | clinicopathological characteristics of hepatocellular carcinoma;GAD |
Disease | Diabetes;KEGG DISEASE |
Disease | type 2 diabetes;GAD |
Disease | Posttransplantation diabetes mellitus (PTDM);GAD |
Disease | Two-hour glucose challenge;NHGRI |
Disease | METABOLIC;GAD |
Disease | Type 2 diabetes and other traits;NHGRI |
Disease | Metabolic syndrome;NHGRI |
Disease | Glycated hemoglobin levels;NHGRI |
Disease | Diabetes mellitus, type 2, susceptibility to;OMIM |
Disease | diabetes, type 2;GAD |
Disease | Fasting glucose-related traits;NHGRI |
Disease | Coronary Artery Disease;GAD |
Disease | diabetes, type 2 glucose insulin;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | type 2 diabetes and other traits;GAD |
Disease | two-hour glucose challenge;GAD |
Disease | Metabolic diseases;KEGG DISEASE |
Disease | body mass cholesterol, HDL diabetes, type 2 glucose insulin metabolic syndrome triglycerides;GAD |
Disease | Type II diabetes mellitus;KEGG DISEASE;H00409 |
External Links | |
Links to Entrez Gene | 6934 |
Links to all GeneRIF Items | 6934 |
Links to iHOP | 6934 |
Sequence Information | |
Nucleotide Sequence | >6934 : length: 4303 GAGGGGAAATGGACATCAATTTCACAGGGTCATCTGATTCCTCATTAGTAGTTCCTATTT GGCAAATTAAAATGCATTTTCAGATAATTGTTGAGATCCTTCAGTGATTATTGTATTGTT TATAAAGTAAATCAGCAGATGGTGTTTGTTTTCCCAATTGATGGGATCCCAAGATTAGCA AGTATTACTTGGGAAGATGAGAATTGGGTGAACAATCTTGCTCTTCCTATTTCGGGATAC CTGCTTCATTGATGGGTGGTCTCTAGGACTTCAGAGGGAAAGGCTGAGGATAGACTTAGA CCTTGGGGAGGGTCTGAGCCAATCAGTGACTTACATTCACTCAGTTGCCATCTAATAGGT GGTCCTCCCTTAGAAAATTGGCGGCTTTCTGGCAGTGTTTGGCCCTCTCTTTGGGGAAGT GTGGATTACTAGAGTGCAGGCGACAGAGATGGCCTGGGATGGACAGCTTAGTCATCATGA AAGAATGTGTAAGGCATCGGGTGGCCCCTGAATTCTGTCTGACACATTTGTTTTCCCAGA AATAGAATTGCATTGGAGAGTTGGGGCCCAGTTATTAGAAATATGGGGATGGGGTGCTTG TACTTGTTGCAGTCTTGTGGCTTCTCATAATCTTTTCTCTCCTAATCCTTCCTCTTGCCT ACATGTTGCAATTCTGATGACTTTTTGCAGCGCACAGTTCATTTTTCTTCAGCATCCCGC TCAGCACACTGGCTTCCTTTATGTCTTAATGGGCATCCGTCTTTCCTTTTCATGTCATTG ATTCTCACTCGTGGCCCCCATCTTCCCTGTATGCTTATTGAATAGGTGCTTAAAAAACAA AAACAAAAACAAAAACAAAAAAACTTTACCTTAGATTGTTATGATCATCTTATCCATAGC AACAAATGAAAGTACACAGGTCTTGATTGAATGCCAAGGCTGCAGTTCAATCTAGGAAGC TCCATTTTCAGTCCGGCAGCACACATTACTCTGCGTACAAAACGATTGAACACCAGATTG CAGTTCAGTATCTCCAGATGAAATGGCCACTGCTTGATGTCCAGGCAGGGAGCCTCCAGA GTAGACAAGCCCTCAAGGATGCCCGGTCCCCATCACCGGCACACATTGTCCAGAGCCCCC TCCCTTGCTGCACTCAGGGACATGACTGTCAGCACTTCTACCCCCCCTCAGACTTCACTG TCAGCACTCAAGTCTTCAGGGACATGAAAAGGAGCCACTCCTTACAAAAAGTTGGGGAGC CCTGGTGTATTGAGTCTAACAAAGTGCCAGTGGTGCAGCACCCTCACCATGTCCACCCCC TCACGCCTCTTATCACGTACAGCAATGAACACTTCACGCCGGGAAACCCACCTCCACACT TACCAGCCGACGTAGACCCCAAAACAGGAATCCCACGGCCTCCGCACCCTCCAGATATAT CCCCGTATTACCCACTATCGCCTGGCACCGTAGGACAAATCCCCCATCCGCTAGGATGGT TAGTACCACAGCAAGGTCAACCAGTGTACCCAATCACGACAGGAGGATTCAGACACCCCT ACCCCACAGCTCTGACCGTCAATGCTTCCATGTCCAGCTTTCTGTCTTCTAGGTTCCCTC CCCATATGGTCCCACCACATCATACGCTACACACGACGGGCATTCCGCATCCGGCCATAG TCACACCAACAGTCAAACAGGAATCGTCCCAGAGTGATGTCGGCTCACTCCATAGTTCAA AGCATCAGGACTCCAAAAAGGAAGAAGAAAAGAAGAAGCCCCACATAAAGAAACCTCTTA ATGCATTCATGTTGTATATGAAGGAAATGAGAGCAAAGGTCGTAGCTGAGTGCACGTTGA AAGAAAGCGCGGCCATCAACCAGATCCTTGGGCGGAGGTGGCATGCACTGTCCAGAGAAG AGCAAGCGAAATACTACGAGCTGGCCCGGAAGGAGCGACAGCTTCATATGCAACTGTACC CCGGCTGGTCCGCGCGGGATAACTATGGAAAGAAGAAGAAGAGGAAAAGGGACAAGCAGC CGGGAGAGACCAATGAACACAGCGAATGTTTCCTAAATCCTTGCCTTTCACTTCCTCCGA TTACAGACCTGAGCGCTCCTAAGAAATGCCGAGCGCGCTTTGGCCTTGATCAACAGAATA ACTGGTGCGGCCCTTGCAGGAGAAAAAAAAAGTGCGTTCGCTACATACAAGGTGAAGGCA GCTGCCTCAGCCCACCCTCTTCAGATGGAAGCTTACTAGATTCGCCTCCCCCCTCCCCGA ACCTGCTAGGCTCCCCTCCCCGAGACGCCAAGTCACAGACTGAGCAGACCCAGCCTCTGT CGCTGTCCCTGAAGCCCGACCCCCTGGCCCACCTGTCCATGATGCCTCCGCCACCCGCCC TCCTGCTCGCTGAGGCCACCCACAAGGCCTCCGCCCTCTGTCCCAACGGGGCCCTGGACC TGCCCCCAGCCGCTTTGCAGCCTGCCGCCCCCTCCTCATCAATTGCACAGCCGTCGACTT CTTCCTTACATTCCCACAGCTCCCTGGCCGGGACCCAGCCCCAGCCGCTGTCGCTCGTCA CCAAGTCTTTAGAATAGCTTTAGCGTCGTGAACCCCGCTGCTTTGTTTATGGTTTTGTTT CACTTTTCTTAATTTGCCCCCCACCCCCACCTTGAAAGGTTTTGTTTTGTACTCTCTTAA TTTTGTGCCATGTGGCTACATTAGTTGATGTTTATCGAGTTCATTGGTCAATATTTGACC CATTCTTATTTCAATTTCTCCTTTTAAATATGTAGATGAGAGAAGAACCTCATGATTCTA CCAAAATTTTTATCAACAGCTGTTTAAAGTCTTTGTAGCGTTTAAAAAATATATATATAT ACATAACTGTTATGTAGTTCGGATAGCTTAGTTTTAAAAGACTGATTAAAAAACAAAAAG AAAAAAAAAGCAATTTTGAAGCAGCCCTCCAGAAGGAGTTGGTTCTGTATTATTTGTATT AAATACGAGCTTGCGAACCAATCATTTTACATCTGGTTTTTAAACCGTAAGGGCACCATG AATGCAGTGCCGTTACTTTTTTTTTTTTTTTCTGTGTGAAACAACTCTTATTGTGATGTT ACTTGTTATTGTTTAAATGTACAGAAACAAAGGGTAAAAATGTGTTAATATACCTTGTTC CATGGTGTTGTTCTTTTGGGGGGAGGGGACGCTACTCAACACTTAATAGAATCACAACGC TGTTGGGCCAGTAGTATTTATTGCTTTAGAGATTGCTTGTCGTACCTGTATGTCGTCCCT TTTTAAATATGTTTTCCTTTTTCTTGAAACTGTATAAAGTTTTTTTCCCCCTTAGCATAA GCATCTTATATATAACAACTCATTTGTACAAGGTTTTTAAGTTTATATATAAAATGTGTA TATATATTTTTGTTTCCCCTTTTTGACTTTTTTTTTTCTGTATGAAACCCAGATGTCACC AAATGGACATTAATAGTTGCATTAAGGATCAGTAGCATTAACAAAAGTTGCTTTAAAAGC CATTATGTAAAACAAGACTTGAAAATGAGTGAGGGAATTTTAGCGACACTGTCTGAGCAG CAGTGGGAACCATCTTCGTTTCCCCTTTGAACTCCCAGTGGGATGCCCTACCCTGCGCCC TTAGGACCCGGACTGACCGTGTACAAAACTTTACGTGCCAAAATTCTCAGTGAATTTAGC TTTCTCCCTCTTTTTGATGCTGTAATTTTTGTTCATCATGTTTTGCTGTGATGTTACATA GGTAGATTTGTATGTAGTTTTAATGTCACCTATAACAAAATGTGTTTGGTAGCAGATTGT CCAGAAAGCATTTTAAATGAAGAGGTATAAACCCTTAAGGGCCAAAATTCTGTATATTAG ATTACTCTTAAACGAAAAACCAGCTGCCGCTTTTATGTACACATATTACATACGAGTAGG CAGCAGACTTTAAAAATAAAAAAAACCTAGGCATGTTGATGTTGCAAAATGCTGTATAAA GCTGAAACCTGTTCATTCAGTGCCATTGTAGTTGACATGAAGCGATTGTAAAACTGTCTC CGATTTTTCTCTGGTTTATTAAAATGCTAACTATAACATTTTTTGTGAATACTTTGAATG TTTCCTAACAGTTGTGATGTTACTGTTCCGTTTTATGCTCTTATTCCAAGTTCATTTTTA ATGGTTTGGAAGCCATTTTTGTAATGAATAAATGTTCATGCTGTACAGTATCTGTAGCAT GCCGTTCTGGATTAATAAAAGCAACTTAGTATGTGCAGATAAA |
Protein Sequence | >6934 : length: 672 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP AHIVQSPLPCCTQGHDCQHFYPPSDFTVSTQVFRDMKRSHSLQKVGEPWCIESNKVPVVQ HPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQ IPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSSFLSSRFPPHMVPPHHTLHTT GIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAK VVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKK KRKRDKQPGETNEHSECFLNPCLSLPPITDANTPKKCRALFGLDRQTLWCKPCRRKKKCV RYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLS MMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQ PQPLSLVTKSLE |