| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6850 |
Name | SYK |
Synonym | p72-Syk;spleen tyrosine kinase;SYK;spleen tyrosine kinase |
Definition | tyrosine-protein kinase SYK |
Position | 9q22 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | ras-independent pathway in nk cell-mediated cytotoxicity;PID BioCarta;100095 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | GPVI-mediated activation cascade;PID Reactome;500294 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | bcr signaling pathway;PID BioCarta;100227 |
Pathway | il 2 signaling pathway;PID BioCarta;100130 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
External Links | |
Links to Entrez Gene | 6850 |
Links to all GeneRIF Items | 6850 |
Links to iHOP | 6850 |
Sequence Information | |
Nucleotide Sequence | >6850 : length: 5129 TCCGGGCTCATGGGCGCGGTCAGCAGGGCGGGCCAGGGCGGCGGGGCGCGACACTGGGAG GAAGTGCGGGCCGCCTGCCCGGGCGCGTTAAGGAAGTTGCCCAAAATGAGGAAGAGCCGC GGGCCCGGCGGCTGAGGCCACCCCGGCGGCGGCTGGAGAGCGAGGAGGAGCGGGTGGCCC CGCGCTGCGCCCGCCCTCGCCTCACCTGGCGCAGGTGGACACCTGCGCAGGTGTGTGCCC TCCGGCCCCTGAAGCATGGCCAGCAGCGGCATGGCTGACAGCGCCAACCACCTGCCCTTC TTTTTCGGCAACATCACCCGGGAGGAGGCAGAAGATTACCTGGTCCAGGGGGGCATGAGT GATGGGCTTTATTTGCTGCGCCAGAGCCGCAACTACCTGGGTGGCTTCGCCCTGTCCGTG GCCCACGGGAGGAAGGCACACCACTACACCATCGAGCGGGAGCTGAATGGCACCTACGCC ATCGCCGGTGGCAGGACCCATGCCAGCCCCGCCGACCTCTGCCACTACCACTCCCAGGAG TCTGATGGCCTGGTCTGCCTCCTCAAGAAGCCCTTCAACCGGCCCCAAGGGGTGCAGCCC AAGACTGGGCCCTTTGAGGATTTGAAGGAAAACCTCATCAGGGAATATGTGAAGCAGACA TGGAACCTGCAGGGTCAGGCTCTGGAGCAGGCCATCATCAGTCAGAAGCCTCAGCTGGAG AAGCTGATCGCTACCACAGCCCATGAAAAAATGCCTTGGTTCCATGGAAAAATCTCTCGG GAAGAATCTGAGCAAATTGTCCTGATAGGATCAAAGACAAATGGAAAGTTCCTGATCCGA GCCAGAGACAACAACGGCTCCTACGCCCTGTGCCTGCTGCACGAAGGGAAGGTGCTGCAC TATCGCATCGACAAAGACAAGACAGGGAAGCTCTCCATCCCCGAGGGAAAGAAGTTCGAC ACGCTCTGGCAGCTAGTCGAGCATTATTCTTATAAAGCAGATGGTTTGTTAAGAGTTCTT ACTGTCCCATGTCAAAAAATCGGCACACAGGGAAATGTTAATTTTGGAGGCCGTCCACAA CTTCCAGGTTCCCATCCTGCGACTTGGTCAGCGGGTGGAATAATCTCAAGAATCAAATCA TACTCCTTCCCAAAGCCTGGCCACAGAAAGTCCTCCCCTGCCCAAGGGAACCGGCAAGAG AGTACTGTGTCATTCAATCCGTATGAGCCAGAACTTGCACCCTGGGCTGCAGACAAAGGC CCCCAGAGAGAAGCCCTACCCATGGACACAGAGGTGTACGAGAGCCCCTACGCGGACCCC GAGGAGATCAGGCCCAAGGAGGTTTACCTGGACCGAAAGCTGCTGACGCTGGAAGACAAA GAACTGGGCTCTGGTAATTTTGGAACTGTGAAAAAGGGCTACTACCAAATGAAAAAAGTT GTGAAAACCGTGGCTGTGAAAATACTGAAAAACGAGGCCAATGACCCCGCTCTTAAAGAT GAGTTATTAGCAGAAGCAAATGTCATGCAGCAGCTGGACAACCCGTACATCGTGCGGATG ATCGGGATATGCGAGGCCGAGTCCTGGATGCTGGTTATGGAGATGGCAGAACTTGGTCCC CTCAATAAGTATTTGCAGCAGAACAGACATGTCAAGGATAAGAACATCATAGAACTGGTT CATCAGGTTTCCATGGGCATGAAGTACTTGGAGGAGAGCAATTTTGTGCACAGAGATCTG GCTGCAAGAAATGTGTTGCTAGTTACCCAACATTACGCCAAGATCAGTGATTTCGGACTT TCCAAAGCACTGCGTGCTGATGAAAACTACTACAAGGCCCAGACCCATGGAAAGTGGCCT GTCAAGTGGTACGCTCCGGAATGCATCAACTACTACAAGTTCTCCAGCAAAAGCGATGTC TGGAGCTTTGGAGTGTTGATGTGGGAAGCATTCTCCTATGGGCAGAAGCCATATCGAGGG ATGAAAGGAAGTGAAGTCACCGCTATGTTAGAGAAAGGAGAGCGGATGGGGTGCCCTGCA GGGTGTCCAAGAGAGATGTACGATCTCATGAATCTGTGCTGGACATACGATGTGGAAAAC AGGCCCGGATTCGCAGCAGTGGAACTGCGGCTGCGCAATTACTACTATGACGTGGTGAAC TAACCGCTCCCGCACCTGTCGGTGGCTGCCTTTGATCACAGGAGCAATCACAGGAAAATG TATCCAGAGGAATTGATTGTCAGCCACCTCCCTCTGCCAGTCGGGAGAGCCAGGCTTGGA TGGAACATGCCCACAACTTGTCACCCAAAGCCTGTCCCAGGACTCACCCTCCACAAAGCA AAGGCAGTCCCGGGAGAAAAGACGGATGGCAGGATCCAAGGGGCTAGCTGGATTTGTTTG TTTTCTTGTCTGTGTGATTTTCATACAGGTTATTTTTACGATCTGTTTCCAAATCCCTTT CATGTCTTTCCACTTCTCTGGGTCCCGGGGTGCATTTGTTACTCATCGGGCCCAGGGACA TTGCAGAGTGGCCTAGAGCACTCTCACCCCAAGCGGCCTTTTCCAAATGCCCAAGGATGC CTTAGCATGTGACTCCTGAAGGGAAGGCAAAGGCAGAGGAATTTGGCTGCTTCTACGGCC ATGAGACTGATCCCTGGCCACTGAAAAGCTTTCCTGACAATAAAAATGTTTTGAGGCTTT AAAAAGAAAATCAAGTTTGACCAGTGCAGTTTCTAAGCATGTAGCCAGTTAAGGAAAGAA AGAAAGAAAAAAAAAAAAGGCCTGGATACTGCTTTTGCTGTCTCTGTTATGAGATGGAAG ACTTACATGTTTGTGATAAAAGGGGACCATGAGAATGAATTGGCTTGGCTTACTTTCCCC CTGAAATCCTCTCTCCTGCAGACTGTCTTGAAGACCTGGTGACTGGTAAATAAAGCCCTG CATGGAGGCTGCACAGCAGGGGCAAGAGGCCCATCCCCCAGCATCTCACTGAGGACAGCT TCAGGCTGCCTTCCTCTGAACGTGGTCCACACCTTCCTCTCCTCCACAGAGAGGGTGCCG CCAGAATCCCCTGTCGCTTTCTGTGTCTGCAATGGGGGGCAGCACAGGGATCAAAGCCAT CTAAAGAGTTTCCAAAGAAAGTATTAATTCAGAACAAGCCAAAGACCCTGAGCCTCACCA CAAACAGGCCTTTTGGAGTGTGAATTTGAGTTGAAGATACAAGATCGGAGAATGATTTTC TGGTCTTAACTAATCCTCATCTTCATGTTTGATCTTTAAGAAGTCATCACCCATTGATTT CAGTTTTGCTGTACCTCTTGAAAGTTAAAGAGACATCTCAGCACTTTAGGAGGCCGAGGC GGGTGGATCACTTGAGGTAAGGAGTTTGAGACTAGCCTGGCCAATATGGTAAAACCCCAT CTCTACTAAAAATACAAAAATTAGCCGGGCATGGTGGCATGTGTCTGTAGTCCCAGCTAC TCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAAACGGAGGTCGCAGTGAGCCAA GATCATGCCACTGCACTCCAGCTTGGGCATCACAGCGAGACTCTGTCAAAACAAACAAAC AAAAAAACAACTTAAAGAGGTAATTTAGCCATCATTCTTATGCCAGCAGATATAAATAAA CTTGGACCCATCTGGTCTTCAGCTAAACCTGAGACATTTTAAAGTGCATGGACAGCCATG GACAGCAGGCCCTCCTCTAACAGGGGATGCAAGGCATGGAGAAAGACAATCAGTACCCAA GCTCAGCCACAGAAGACAGGAGTCACTCATATAACTTGTGTTTAGAAGTTTTTGGTAGCC ACGCACACTTTCTGAAATCACACTATCTGGTGGTTTAATCATATTTTTAAAGACAGAATC CCTGAGTGCTGAGCAGATTCTCAAAACACATTTAGAATCCCTGAAATTAGAAAGATCAAT GACAAAATATCTGTCAGCCAGGCCACAAACAGGTGTAAAATTATGAAAGGAGTGGTTGGA TGTGCCAAGTTTGGTAAAGTGGTGACTGCATCTGAGAAAGAGGCTGTGAGGCTGAACTCT TGGTGGCTTCCTTCTGTAACTTCCAGAGGGAGTCTTCAACACAGGCCCCGTGCTCGTAGG AATACGGTAGCACCTATGTAGGAAGTGCGTGGAGTTTTCTGTCTTCTTTCTGTGTGATTT TTGGCCTTTTTATCAGCACTTCTCCCCTCCCAGGAGCCTGGGGATGCCAAACATCCAGAA TGTGATGGGACAAGATGGGGGCAGGGGCCTCACCTCCCTGCAGAGGTCCGGCCAGGTCTC CTTGTCCCTGGACAATCTCCTGAGCCTCTCTGCTTGGTGGAGCAGGCACCTGTGTGCAGA ATTCCCACTGTGGCCAGCACGAGGAAGTCTTTTCTAGTGAAAATGTGTCTTGTGGTCAGG AATAATTATCCTTTCCCCTGTAGCCACCAAGGAGGGCAAATAGAGAAAGGTAACCTAATT GAAGGATTGGTCATGTGAAAAGGGCTACATTTGGGAAGCTGGGAAAGGCCTCCAGGCTTC TAGAGCAGCTAGCTTGGGCTGGATTCTCATACCCAGGCTGCCCCTTGGATTGTTCTACCC AAGCTTTTCCCTGGGGTCTGGGCTCACTCCATAAGGTAAGGTGCCTTTTACCTTATGGTC CTTCTTTAGCAGGTAACAAAGGAGCATCAGGGGCAGGCTGCCCTGGTGGCATCACACTGG CTAGTGAGGCCGTGAATATCTTGTCCCCCAGCAGGGCCGACAGTTTCTATCACAGAAAAC AGTGTGTTCAGTGGTGAAAATCGTTGCATGCATGTTTTCATCTGAGCGTGTCCTTCTCCC ATACTCCCTATCAGCCAGCCCTGCCTGTAGCTGCTGTATGGTGATTGCACTTGGACATCA GTCCAATGACTGCAAGTCGGCCTGGATTTTCACTTGCAGAGGCTACAGCTGCATTGTCAG GTCTCCCAGCCCTGCAGAGAGCTCCCTCCACTGGTTAGCAGTGTGTTGTGTTTTCCATTC ATTTCAGAAGAGCTACATTGTGTCACTGGACATTTTTAAAAACTGTGATTTTTAATAAAA ATTTAAAATTTGCTTTGTGATGAAAAAAA |
Protein Sequence | >6850 : length: 635 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN |