| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 57580 |
Name | PREX1 |
Synonym | P-REX1;phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1;PREX1;phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
Definition | phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein|ptdIns(3,4,5)-dependent Rac exchanger 1 |
Position | 20q13.13 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Regulation of RAC1 activity;PID Curated;200165 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Disease | tonometry;GAD |
Disease | Tonometry;NHGRI |
External Links | |
Links to Entrez Gene | 57580 |
Links to all GeneRIF Items | 57580 |
Links to iHOP | 57580 |
Sequence Information | |
Nucleotide Sequence | >57580 : length: 6633 CGGCGCCGCGCGGCCGCGCTAGAATGGAGGCGCCCAGCGGCAGCGAGCCCGGCGGCGACG GGGCCGGGGACTGCGCCCACCCGGACCCCCGGGCCCCTGGCGCCGCGGCGCCCAGCTCCG GCCCCGGCCCGTGCGCGGCCGCCCGGGAGTCCGAGCGCCAGCTGCGCCTCCGCCTCTGCG TCCTCAACGAGATCTTGGGCACCGAGAGGGACTACGTGGGCACCTTGCGCTTCTTGCAGT CGGCATTCCTGCATCGCATCCGGCAGAACGTGGCCGACTCAGTGGAGAAGGGCCTCACGG AGGAGAATGTCAAGGTCCTGTTCTCGAACATCGAAGACATCCTGGAAGTTCATAAGGATT TCTTGGCCGCCTTGGAGTATTGTTTACACCCGGAGCCGCAGTCTCAGCATGAACTTGGGA ATGTTTTCTTAAAATTCAAGGACAAGTTCTGCGTGTACGAGGAGTATTGCAGCAACCATG AGAAAGCCCTGAGGCTGCTGGTGGAGCTGAACAAGATCCCTACCGTGCGCGCCTTCCTTT TGAGCTGCATGCTTCTGGGAGGCCGGAAGACCACGGACATCCCTTTGGAAGGCTACCTGT TGTCTCCGATCCAGAGGATCTGCAAGTACCCGCTCCTCCTTAAGGAGCTGGCCAAGAGGA CTCCCGGCAAGCACCCAGACCACCCCGCGGTCCAGAGTGCCCTGCAGGCCATGAAGACCG TTTGCTCCAACATCAATGAGACCAAGCGGCAGATGGAGAAGCTGGAAGCCCTGGAGCAGC TGCAGTCCCACATCGAAGGCTGGGAGGGTTCCAACCTCACAGACATCTGCACTCAGCTCC TCCTGCAAGGGACTTTGTTAAAGATCTCTGCGGGCAACATCCAGGAAAGGGCCTTCTTCC TCTTCGACAACCTTCTCGTCTACTGCAAGCGGAAATCCAGGGTCACCGGGAGCAAGAAGT CCACCAAGAGGACCAAATCCATCAACGGCTCCCTCTACATCTTCAGGGGTCGAATCAACA CTGAAGTCATGGAGGTGGAGAATGTGGAAGATGGGACAGCGGATTACCATAGCAACGGCT ATACCGTCACCAACGGCTGGAAGATCCACAACACGGCCAAGAATAAGTGGTTTGTCTGCA TGGCCAAGACGGCAGAGGAGAAGCAGAAGTGGCTGGATGCCATCATCCGCGAGCGGGAGC AGCGCGAGAGCCTGAAGCTGGGCATGGAGCGTGATGCCTACGTCATGATTGCGGAGAAGG GGGAGAAGCTGTACCACATGATGATGAACAAGAAGGTGAACCTCATCAAGGACCGCCGGA GAAAGCTGAGCACTGTCCCCAAGTGCTTTCTTGGCAATGAGTTCGTTGCCTGGCTCCTAG AAATTGGTGAAATCAGCAAGACGGAAGAAGGAGTCAACTTGGGCCAAGCCCTGTTGGAGA ATGGCATCATCCACCATGTTTCCGACAAGCACCAGTTCAAGAATGAGCAGGTGATGTATC GCTTCCGCTACGACGATGGCACCTACAAGGCCCGAAGTGAGCTGGAGGACATCATGTCCA AGGGTGTGAGGCTTTACTGCCGTCTTCACAGCCTCTACACCCCGGTGATCAAAGACCGTG ATTACCACCTGAAGACCTACAAGTCAGTGCTTCCCGGGAGCAAGCTGGTGGACTGGCTGC TGGCTCAGGGAGACTGCCAGACTCGGGAGGAGGCAGTGGCGCTCGGCGTGGGTCTGTGCA ACAATGGCTTCATGCACCACGTGCTGGAGAAGAGCGAGTTCAGGGATGAGTCCCAGTACT TCCGCTTTCATGCTGACGAGGAGATGGAGGGGACCAGCAGCAAGAACAAACAGCTTCGCA ACGACTTCAAGCTGGTGGAGAACATTCTGGCCAAGCGCCTGCTGATCCTGCCCCAGGAGG AGGACTATGGCTTTGACATCGAGGAGAAGAACAAGGCTGTGGTGGTGAAGTCCGTCCAGA GGGGCTCGCTGGCTGAGGTGGCTGGCCTGCAGGTGGGGAGGAAGATCTACTCCATCAATG AGGACCTGGTGTTCCTGCGGCCGTTTTCAGAGGTGGAGTCCATCCTCAACCAGTCCTTCT GCTCCCGCCGCCCTCTGCGCCTCCTGGTGGCCACGAAGGCCAAAGAGATCATCAAAATCC CCGACCAGCCGGACACACTGTGCTTCCAGATTCGTGGAGCTGCCCCACCGTACGTCTATG CTGTGGGGAGAGGCTCTGAGGCCATGGCTGCAGGGCTCTGTGCTGGTCAGTGCATTCTGA AGGTCAATGGCAGCAACGTGATGAACGATGGTGCCCCTGAGGTCCTGGAGCACTTCCAGG CATTCCGGAGTCGGCGCGAAGAGGCCCTGGGCCTGTACCAGTGGATCTACCACACCCATG AGGATGCCCAGGAAGCACGAGCCAGTCAGGAGGCCTCCACTGAGGACCCCAGTGGCGAGC AGGCCCAGGAGGAAGACCAGGCTGATTCAGCCTTCCCACTGCTGTCCCTGGGTCCCCGGC TGAGCCTGTGTGAGGACAGCCCCATGGTCACCCTGACTGTGGACAACGTGCACCTGGAAC ACGGCGTGGTGTATGAGTATGTGAGCACGGCAGGCGTCAGGTGCCATGTGCTGGAGAAGA TCGTGGAGCCCCGCGGCTGCTTCGGCCTCACCGCCAAGATCCTCGAGGCCTTTGCTGCCA ATGACAGCGTCTTCGTGGAGAACTGCAGGCGGCTCATGGCCCTGAGCAGCGCCATCGTGA CCATGCCCCACTTTGAGTTCCGCAACATCTGTGACACCAAGCTGGAGAGCATTGGCCAGA GGATTGCCTGCTACCAGGAGTTTGCAGCCCAACTGAAGAGCAGGGTCAGCCCACCCTTCA AACAAGCCCCCCTGGAGCCCCACCCGCTGTGTGGCCTGGACTTCTGCCCCACCAATTGCC ACATCAACCTCATGGAAGTGTCCTACCCCAAGACCACCCCCTCAGTGGGCAGGTCCTTCA GCATCCGCTTTGGACGCAAACCCTCCCTCATCGGCCTTGACCCGGAGCAAGGCCACCTGA ACCCCATGTCGTACACCCAGCACTGCATCACCACCATGGCTGCTCCCTCCTGGAAGTGCT TGCCTGCTGCAGAGGGTGATCCCCAAGGCCAGGGTCTCCATGATGGCAGCTTCGGGCCAG CCAGTGGGACCCTTGGTCAGGAAGACCGGGGCCTCAGCTTCCTACTCAAGCAGGAGGACC GTGAGATCCAGGATGCCTACCTGCAGCTCTTCACCAAGCTGGATGTGGCCCTGAAGGAGA TGAAGCAATATGTCACCCAGATCAACAGGCTGCTGTCCACCATCACAGAGCCCACCTCGG GTGGGTCCTGCGACGCATCCTTGGCTGAGGAGGCCTCCTCCCTGCCCCTGGTCAGTGAAG AGAGCGAGATGGACAGGAGTGACCATGGGGGCATCAAGAAGGTGTGCTTCAAGGTGGCCG AGGAGGACCAGGAGGACTCAGGCCACGACACCATGAGTTATCGCGACTCCTACAGCGAGT GTAACAGCAATCGAGACTCGGTCCTGTCCTACACCAGCGTGAGAAGTAACAGCTCCTACT TGGGCAGCGACGAGATGGGGTCTGGAGATGAGCTGCCCTGTGACATGCGGATCCCATCTG ACAAGCAGGACAAGCTTCATGGCTGCCTGGAGCACCTCTTTAACCAGGTGGACTCCATCA ATGCTCTCCTCAAGGGGCCAGTCATGAGCCGGGCTTTCGAAGAGACCAAGCATTTCCCTA TGAACCACAGCTTACAAGAGTTTAAACAGAAAGAAGAGTGTACAATCCGTGGCCGGAGCC TGATCCAGATTAGCATCCAGGAGGACCCCTGGAACCTCCCCAACTCCATCAAGACCCTGG TGGACAACATTCAGAGATATGTGGAAGATGGGAAGAACCAGCTGCTCCTGGCCTTGCTGA AGTGCACAGACACGGAGCTGCAGCTGCGCAGAGACGCGATCTTCTGCCAGGCCCTGGTGG CCGCCGTGTGCACCTTCTCCGAGCAGCTGCTGGCGGCCCTGGGCTACCGCTACAACAACA ATGGCGAGTACGAGGAGAGCAGCCGCGACGCCAGCCGCAAGTGGCTGGAGCAGGTGGCGG CCACGGGCGTCCTGCTGCACTGCCAGTCCCTGCTCTCGCCAGCCACAGTGAAGGAGGAAC GGACCATGCTGGAGGACATCTGGGTGACGCTGTCAGAGCTGGACAATGTCACCTTCTCCT TTAAGCAGCTGGACGAGAACTATGTGGCCAACACCAACGTCTTCTACCACATTGAGGGCA GCCGGCAGGCGCTGAAGGTCATCTTCTACCTCGACAGCTACCACTTCTCCAAGCTGCCCT CCCGCCTGGAGGGTGGGGCCAGCCTGAGGCTGCACACAGCGCTGTTCACGAAAGTGCTGG AGAACGTGGAGGGGCTGCCTTCTCCAGGCAGCCAGGCCGCGGAGGATTTGCAGCAGGACA TCAACGCGCAGTCCCTGGAGAAAGTTCAGCAGTATTACCGCAAACTCAGGGCATTTTACC TGGAGCGGTCTAACCTGCCCACGGATGCCAGCACCACGGCGGTAAAGATAGACCAGCTGA TCCGCCCCATCAATGCCCTGGATGAGCTCTGCCGCCTCATGAAGTCCTTTGTCCACCCAA AGCCTGGTGCTGCTGGGAGTGTGGGCGCCGGCCTCATCCCCATCTCCTCGGAGCTCTGCT ACCGCCTGGGGGCCTGCCAGATGGTCATGTGTGGCACAGGCATGCAGAGGAGCACCCTGA GCGTGTCCCTGGAGCAGGCGGCCATCTTGGCACGGAGCCACGGGTTGCTGCCCAAGTGCA TCATGCAGGCCACGGACATCATGCGGAAGCAGGGCCCAAGGGTGGAGATTCTGGCCAAAA ACCTGCGAGTCAAGGACCAGATGCCCCAGGGTGCTCCGCGCCTCTACCGCCTCTGCCAGC CGCCGGTGGATGGGGACCTCTGAACACCCAAATGCCCCACGCTGGGCCGCGGCCTCTGGA GCTGGGATTTGGGAGGACACAGCAGGCAGCGCTGGCCTTCTCCAGGGATGGCCCAAGGCT TCCGCAGCCGCCCGTTCCGGGACCTGCCCAGCGTCCTCCCTGCCTCCTTCCGGGACAAGC CTGGCCACCCTCGCTGTGATGACGAGCTGGCTGATTGGCCCTGGGCCGGCCCATTCTTCA CACGCCTGCCAGAAGCTGGAGGGGTGCTGGAGACCCATAGAGCTGATGGGAGCAGCTGGT GCCTGGCCTTCGGCTCCTGCGTCCCCAGAACCCAAGGGAACGTCATGGAGGCCACATGGG GCCACCCGGCTCCCTCGGGATGGCTCCGCCTGCACTTTTGAAACCCCGGTTTCCTTCAAC GTCCACATTCCAGGTGACCACACGTGTCTCCTCCTCCTCATCTTAGCTTCCAGGTTCACC CTAACCCTGTACTAACCTGCTTGGTGGACTTGGAAAAGACTTGGCTCTGTCGGGAAAGGA GAGACGGGGCCTCCATCACGCCTGTTACCAGAGGATCCCCGAGAGCCACACCAGCTCTGG ACATCACCGCCCCTGGAACTGGGGCCACCAGCCCTGGGCACGAGATTTGCTCTGACTTTA TTTATATGGCATGAAATCTCTGGTTTATTTTGGGATTTTTTGTTGTTGGTGTTGTCAAAG TTTGTTTTTTCTAAAGTTGTGTGATTATATATTTGACATTTTACATTTCAAAGAAAGGTA TGTTGTCTAACAGGGGACCAACAGAAGGTAGTATTGACAACTGTTCCTGCTTCTACTAAA AAAAAAAGAGCACAAAAGAAAAACTAAATTATTGAAAAATTAAAAAATGTCATTGTTTCC TGTTTGTTAATATTAGGGTTGTAAGGTGTCGTTTTGAGGTATCGACTGTGATTCCTTCCC CCACCCTCCATTCTCCAGCGGTTGGCCGGTGTTAGAACTCGCTCTCTTTGAGTGACTGGC TACAAGGGCCTGAGAGGTGGCCAGCCAGGGTTGGAGCTGGAGGGGATGGAGCCCCACCTG AGGTGCCGTGTCACACGGGTTAGAGGGTCACTGGGAAACACCGGGCGGTGGCTTCTGTGA TTTATTTTCTTGATGGTAACTTCTCAGAGCAGGGCGATTGGGACATCACCAGCCAGAGCA CAGGAAGCCACCCTGCCTGCTGGGGAGGAGGGACCCACACAAGCCCCCTCGGCAGTTTGT CCCCCCAGCTTCGGTATGCCTTCAGGGAAAGGTCACAGCTGGGGAGGAAGCGGGGGGACG CCTGTCACCCCTGGCAGGTGGTGAGTTCAGGTGGGGGCTCCCTGCTGCCCCCAGGCCTGG GAGCTTGAAGCCCTCCCGGCATCTGGCATCCGAGCCTCCCGCCCTCCAGGGTGCGCTTCC CTCTCTTGCCGCAGCATACACGAGGGCAGGCAGTGGCCTTGTCACTGTATCTTGCATCAG AGACAAAGGAGGACCCGCTTTAGCCCTGCTGCGGGAAATGGGGGAGGGCCCAGGGCCAGC GCATTGTGCACTGGTTTACTTTAAAATGTACAGATTCTTCTCGTTAAATTCTTGATAGAT TTTTTATTATTATTAAAAGTCAGTTTATAATAC |
Protein Sequence | >57580 : length: 1659 MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGT ERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYC LHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGG RKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINET KRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVY CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWK IHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMM MNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS DKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEE MEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVA GLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLC FQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREE ALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSP MVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVEN CRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPH PLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQH CITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYL QLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSD HGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGS GDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEF KQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ LRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVI FYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEK VQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSV GAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIM RKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDL |