| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5740 |
Name | PTGIS |
Synonym | CYP8|CYP8A1|PGIS|PTGI;prostaglandin I2 (prostacyclin) synthase;PTGIS;prostaglandin I2 (prostacyclin) synthase |
Definition | cytochrome P450, family 8, subfamily A, polypeptide 1|prostacyclin synthase|prostaglandin I2 synthase |
Position | 20q13.13 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Prostanoid metabolism;PID Reactome;500770 |
Pathway | Eicosanoids;PID Reactome;500201 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | eicosanoid metabolism;PID BioCarta;100180 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | prostanoid biosynthesis;BioCyc;PWY66-374 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | Arachidonic acid metabolism;KEGG PATHWAY;hsa00590 |
Disease | REPRODUCTION;GAD |
Disease | hypertension;GAD |
Disease | breast cancer;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | cardiovascular;GAD |
Disease | CANCER;GAD |
Disease | Myocardial Infarction;GAD |
Disease | Hypertension, essential;OMIM |
Disease | Cerebral Infarction;GAD |
Disease | patent ductus arteriosus;GAD |
External Links | |
Links to Entrez Gene | 5740 |
Links to all GeneRIF Items | 5740 |
Links to iHOP | 5740 |
Sequence Information | |
Nucleotide Sequence | >5740 : length: 5603 GGAGTGGGCCAGGCCGCCAGCCCCGCCAGCCCCGCCAGCCCCGCCAGCCCCGCGATGGCT TGGGCCGCGCTCCTCGGCCTCCTGGCCGCACTGTTGCTGCTGCTGCTACTGAGCCGCCGC CGCACGCGGCGACCTGGTGAGCCTCCCCTGGACCTGGGCAGCATCCCCTGGTTGGGGTAT GCCTTGGACTTTGGAAAAGATGCTGCCAGCTTCCTCACGAGGATGAAGGAGAAGCACGGT GACATCTTTACTATACTGGTTGGGGGCAGGTATGTCACCGTTCTCCTGGACCCACACTCC TACGACGCGGTGGTGTGGGAGCCTCGCACCAGGCTCGACTTCCATGCCTATGCCATCTTC CTCATGGAGAGGATTTTTGATGTGCAGCTTCCACATTACAGCCCCAGTGATGAAAAGGCC AGGATGAAACTGACTCTTCTCCACAGAGAGCTCCAGGCACTCACAGAAGCCATGTATACC AACCTCCATGCAGTGCTGTTGGGCGATGCTACAGAAGCAGGCAGTGGCTGGCACGAGATG GGTCTCCTCGACTTCTCCTACAGCTTCCTGCTCAGAGCCGGCTACCTGACTCTTTACGGA ATTGAGGCGCTGCCACGCACCCATGAAAGCCAGGCCCAGGACCGCGTCCACTCAGCTGAT GTCTTCCACACCTTTCGCCAGCTCGACCGGCTGCTCCCCAAACTGGCCCGTGGCTCCCTG TCAGTGGGGGACAAGGACCACATGTGCAGTGTCAAAAGTCGCCTGTGGAAGCTGCTATCC CCAGCCAGGCTGGCCAGGCGGGCCCACCGGAGCAAATGGCTGGAGAGTTACCTGCTGCAC CTGGAGGAGATGGGTGTGTCAGAGGAGATGCAGGCACGGGCCCTGGTGCTGCAGCTGTGG GCCACACAGGGGAATATGGGTCCCGCTGCCTTCTGGCTCCTGCTCTTCCTTCTCAAGAAT CCTGAAGCCCTGGCTGCTGTCCGCGGAGAGCTCGAGAGTATCCTTTGGCAAGCGGAGCAG CCTGTCTCGCAGACGACCACTCTCCCACAGAAGGTTCTAGACAGCACACCTGTGCTTGAT AGCGTGCTGAGTGAGAGCCTCAGGCTTACAGCTGCCCCCTTCATCACCCGCGAGGTTGTG GTGGACCTGGCCATGCCCATGGCAGACGGGCGAGAATTCAACCTGCGACGTGGTGACCGC CTCCTCCTCTTCCCCTTCCTGAGCCCCCAGAGAGACCCAGAAATCTACACAGACCCAGAG GTATTTAAATACAACCGATTCCTGAACCCTGACGGATCAGAGAAGAAAGACTTTTACAAG GATGGGAAACGGCTGAAGAATTACAACATGCCCTGGGGGGCGGGGCACAATCACTGCCTG GGGAGGAGTTATGCGGTCAACAGCATCAAACAATTTGTGTTCCTTGTGCTGGTGCACTTG GACTTGGAGCTGATCAACGCAGATGTGGAGATCCCTGAGTTTGACCTCAGCAGGTACGGC TTCGGTCTGATGCAGCCGGAACACGACGTGCCCGTCCGCTACCGCATCCGCCCATGACAC AGGGAGCAGATGGATCCACGTGCTCGCCTCTGCCCAGCCTGCCCCAGCCTGCCCCAGCCT CCCAGCTTTCTGTGTGCACAGTTGGCCCGGGTGCAGGTGCTAGCATTACCACTTCCCTGC TTTTCTCCCAGAAGGCTGGGTCCAGGGGAGGGAAAAGCTAAGAGGGTGAACAAAGAAAAG ACATTGAAAGCTCTATGGATTATCCACTGCAAAGTTTTCTTTCCAAAATCAGGCTTTGTC TGCTCCCAATTCACCTCGTTACTCTCACCTCGTGATATCCACAAATGCTATTCAGATAAG GCAGAACTAGGAGTCTTCACTGCTCTGCCCCCAACTCCCGGAGGTGTCACCTTCCTAGTT CTTATGAGCTAGCATGGCCCGGGCCTTATCCAGTCAAAGCGGATGCTGGCCACAGAAAGG CCACTCAGGATGTCCTTTGTGTCCATTGATGTCATTCAGCAGTCAGTCCCCCAATAATCC TTAAACTAGCTAAAACCAAAGGAGTCCCTTAGAAGATCTGCTTCCCTGGGGCCCCATTTG CCAGATTGCCCCATTGCTCACACTACTTGAGAAAATGCAGGAGAGCTTCCCCCAAGGCTG ATGCATTCCCGGTGCAGAACAGGGGCACCCTCCAAACACTGGGCTCTGAGGAGTGGAGTT CTCTGTTCTAGAGTGACAGGCACCAGATGGGATGGGCTTTCTCAGTGTCAGCACTCAGGT AGGGAGCTAAGGAAGACACAGCCCAGACAAGATGGCTGGAAGGAGCCAGCCAGGACTCCT TAGACTGATCAAGCCAAAAAAGAAGGTGCCGATTTCATGCATTCTAGTGCAGAAGCCCCA ACTGTGATCACGATCCAGTCTGCAGACGTGTTTTGTTTGGACTTCACTTAAAAAAATGCC TTAGTTGTTATCATCTTTGGGAGAGTTCATTCAAAATGTCCAGCTTCTCTTGAAAACTTG GTATATCTGGCCACACTGGGCTCACATTCCCAAGGGTAACTCTTGGCCAGAGCTGAGTGG CAGCCGCCTCCCTTATGCAGGACATGTGCTCTCGGCTTCACCAGGGTTCTGACCGGGTCT GCTTCTGCATTCACAGCGCCTCCTGGACCTGAAGGCATCTGAGTGTGAGACCCTGTTCTA ACTCTTAGAAGTGACATTGTAAGAGGTGGTGGGGACCAGCTAATTGGTCCAACCCAGCCT GAGTGCACCACCCTTTGAACAAATGTATCAGTGATGAAAATTTGCCTTTGCCCCGGCTTG CCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCGGGAGTTCA AGACCAGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAACATAAAAAAATTAGTCAG GTGTGGCGGTGCGTGCCTGTAATCCCAGCTATTCAGGAGGCTGAGGCACCAGAATTGCTT GAACCCAGGAGGTGGAGGTTGCAGTGAACTGAGACTGCGCCACGGCACTCCAGCCTGGGC GACAGAGCAAGACTCTGTCTCAATAAATAAATAATTAATTAAAATAAAAAACAGCTTAAA GAGAAAAATGGCCTGCAAACCTTTTTTATGATGCTATTTTTATTAATATAAAGTCCTGTT TATTGAGACCCTTTAAATGCCTGCGAGAGACCCTACAGACAGTATGTCTACTCCTCACAG CATCTCTATGAAGAGAAGGAGGGTTGTGCCCACTTCATAGATGAGAAAACTGAGAGGTGA GGTGACTTGCCTGGGGCCACATAGCTCATAAGCTGTAGAACTCTGCAGGCAGATTTACTG TCCCAGGAGCAAATGCTGGATGAGCAACTCCTGTTCTTTGGGCTCAAGGGGACTGGTGAT GGGACAATTCTTCTCGACTTCAGGAGCTGACAGAGCCAGAGGCACCTAAACTTGGGTACA TCTTGTAAGACACATAATGAGGTCCCTCTAGCTTTAGCTGGAGGGAGATAAAAGAACCCC AGACCTCTGAATGTCCCAGAGGCTAGTCTCTTCTCAGAGCAGCACTGGGGTTTGGGGGCT TCCCTGGGCCTCAGCCTCCAGGCACCCCCAGGATTCCCAGAGAGACGCTGTGATTGGCAG GAGGCAGGATATCCCCAGGGAAACCCATCTTCACGCCTGGGTGACCCCCACTGCCGCCTC CTTCTTAACTCTGCAGGAAATCAGAGCTGGCAGCCTCCAGTGGGAGGACAGAGCCGGTTT CCGTGGCAACCCTCAGCTGCCTCATCGTGGCTGGGAAGGGAAGGAAGCAAGCCGGCAGAA ATAGCTATGGAAGGTCTTGCGCAGGCTGCAACCCTGGTGTGCTGGGCGAAAACCCTTATG ACTCCCCCCTTCCAAATCAGGCTGGGTTGTCACTGAGACTAGATTCTCACCTGCCTTCAA AGAAGGGCCAATTCCCTTTAAAGGTCGCACCTCCTTGGAACCACAGTCATTAGTGAATTA CACTCAAGGAAAAGATGTGCTCCCACCAGGCAGCTCCAGCTGTTACCTGAGATACTGAAG TGCAGCTCAGGAGACGATTATTTAAACCTGCCCTTGTTTTAATCGTTATTTTTCTCTTTA AAAAAAATAGAAGCTATAAAGAAAAGAGGGAGAGATGAGTGGGTTAGCTACCTGCTATGC GCTAGTTAGGAAGTTACCTGGATGCCATTGTATTTCTTCATCCCTTGCTTAAGAATCAAA ATTACTGGACATATGTTAGGAATACTCTTTCTTTCTTTCTTTCTTTTTAAGCTCAGTGGC AAGAATGAAATACTCTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGCTGCCCA GGCTAGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTCTGCCTCCCGTGTTCACACC ATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCACACCCGGC TAATTTTTGGATTTTTAGTAGAGATGGGATTTCACCGTATTAGCCAGGATGGTCTTGATC TCCTGAGCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGC CACCGCGCCCAGCCAAGAATAAAATACTCTTAAGTTGATCTAATGAAGTGTTTCCTTACC ATTGTGATTATTGTTACTATTATTTGCTATATTTTAATATTGTTGTTTACCAAATATTCT CCTTTAAACAGACTCGCTTTTTAAACTTTTTTTTTTTTTTTTGAGACGGAGTTTCACGCT TATTGCCCAGGCTGGAGTGCAATGGCACGATCTCAGCTCACCACAACCTCCACCTCCTGG GTTTAAGCAATGCTTCTGCCTCAGCTTCCCAAGTAGCTGAGATTACAGGCGCACACCACC ACGCCCAACTGATTTTTGTATTTTTAGTAGAGACGGGGTTTCCCCATGTTGGTCAGGCTG GTCTCGAACTCCTGACCTCGTGATTTGCCTGCCTGGGCCTCCCAAAGTGCTAGGATTACA GGCATGAGCCACCATGCCCGGCCTAAACTTTGTTTTTAAAATGAACTTTTTTTCCCCCCA ATTGCTGCCAATAGTGGATAACATGTATCACTCACTGCCAAAAATAGAAAGTGACCATGA AAAATAAATTCGCTGGGGAAGGGGGCTCCATGCTGGTGTGGCCAAGGCTGAGAGCTCTCT CTTCTCTGTTACAAAACGAGATAAGCAAGTGTTAGAATTGCCTTAAGGCCACACTGGCAT CTCCCTGACCTTCTCCAGGGACAGAAGCAGGAGTAAGTTTCTCATCCCATGGGCGACCAG GGCCATCTCCTCCCACCAGTGGCCCCCACTCACAGGGAGCTGGCAATGCCCTACCTGCCT GTTCTCCAGATGGAGAAACAGGCTCTGAGATTTCACAGGTCTTGCCCAAAGTCATTGATT TTGATGATTAAAAAGAATAAACACAGTGTTTCCTGAGTAGCAGTGATTGTTATGCCTTGC TATTTTAATAAAGATTCTATTTTCGTATAACATTGTCAAGTGGAAACATGCTGAAATCTA TTAAACCATCTTTGTTTGTGGAA |
Protein Sequence | >5740 : length: 500 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR YGFGLMQPEHDVPVRYRIRP |