| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 54658 |
Name | UGT1A1 |
Synonym | BILIQTL1|GNT1|HUG-BR1|UDPGT|UDPGT 1-1|UGT1|UGT1A;UDP glucuronosyltransferase 1 family, polypeptide A1;UGT1A1;UDP glucuronosyltransferase 1 family, polypeptide A1 |
Definition | UDP glycosyltransferase 1 family, polypeptide A1|UDP-glucuronosyltransferase 1-1|UDP-glucuronosyltransferase 1-A|UDP-glucuronosyltransferase 1A1|UGT-1A|UGT1*1|UGT1-01|UGT1.1|bilirubin UDP-glucuronosyltransferase 1-1|bilirubin UDP-glucuronosyltransferase i |
Position | 2q37 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Steroid hormone biosynthesis;KEGG PATHWAY;hsa00140 |
Pathway | Heme degradation;PID Reactome;500861 |
Pathway | Starch and sucrose metabolism;KEGG PATHWAY;hsa00500 |
Pathway | Porphyrin and chlorophyll metabolism;KEGG PATHWAY;hsa00860 |
Pathway | Metabolism of xenobiotics by cytochrome P450;KEGG PATHWAY;hsa00980 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | Pentose and glucuronate interconversions;KEGG PATHWAY;hsa00040 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Drug metabolism - other enzymes;KEGG PATHWAY;hsa00983 |
Pathway | Ascorbate and aldarate metabolism;KEGG PATHWAY;hsa00053 |
Pathway | Drug metabolism - cytochrome P450;KEGG PATHWAY;hsa00982 |
Pathway | Retinol metabolism;KEGG PATHWAY;hsa00830 |
Pathway | Metabolism of porphyrins;Reactome;REACT:9431 |
Disease | HEMATOLOGICAL;GAD |
Disease | Hyperbilirubinemia, familial transcient neonatal;OMIM |
Disease | Drug Hypersensitivity;GAD |
Disease | 1-hydroxypyrene, urinary;GAD |
Disease | sickle cell anemia;GAD |
Disease | irinotecan pharmacokinetics;GAD |
Disease | cholelithiasis;GAD |
Disease | Gilbert syndrome;GAD |
Disease | Bilirubin levels;NHGRI |
Disease | Inherited disorders of cofactor/vitamin metabolism;KEGG DISEASE |
Disease | irinotecan pharmacokinetics lung cancer;GAD |
Disease | cardiovascular disease;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Gilbert syndrome;OMIM |
Disease | METABOLIC;GAD |
Disease | agranulocytosis;GAD |
Disease | irinotecan pharmacogenetics;GAD |
Disease | colorectal cancer;GAD |
Disease | Serum bilirubin levels;NHGRI |
Disease | Genetic disorders;KEGG DISEASE |
Disease | CARDIOVASCULAR;GAD |
Disease | Gilbert's syndrome;GAD |
Disease | CANCER;GAD |
Disease | hyperbilirubinemia;GAD |
Disease | Crigler-Najjar syndrome, type II;OMIM |
Disease | carvedilol pharmacokinetics;GAD |
Disease | Bilirubin, serum level of, QTL1;OMIM |
Disease | Hemolysis;GAD |
Disease | bilirubin;GAD |
Disease | leukemia;GAD |
Disease | irinotecan toxicity;GAD |
Disease | gastrointestinal toxicity;GAD |
Disease | breast cancer;GAD |
Disease | neonatal hyperbilirubinemia;GAD |
Disease | Choledocholithiasis;GAD |
Disease | endometrial cancer;GAD |
Disease | Hyperbilirubinemia;KEGG DISEASE;H00208 |
Disease | ovarian cancer;GAD |
Disease | serum bilirubin concentration;GAD |
Disease | Crigler-Najjar syndrome, type I;OMIM |
External Links | |
Links to Entrez Gene | 54658 |
Links to all GeneRIF Items | 54658 |
Links to iHOP | 54658 |
Sequence Information | |
Nucleotide Sequence | >54658 : length: 2357 AGGAGCAAAGGCGCCATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTG CTGCTGTGTGTGCTGGGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTG GATGGCAGCCACTGGCTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACAT GAAATAGTTGTCCTAGCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACC TTGAAGACGTACCCTGTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTC GGGCATAATGTTTTTGAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAA ATAAAAAAGGACTCTGCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAG CTCATGGCCTCCCTGGCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCT TGCAGCCCCATCGTGGCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTG CCATGCAGCCTGGAATTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGG CCTCTCTCCTCTCATTCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATT GCCTTTTCACAGAACTTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCA GAATTCCTTCAGAGAGAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTG TTTAGAAGTGACTTTGTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTT GGTGGAATCAACTGCCTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAAT GCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCA GAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGG CGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTA CCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCC CATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGT GATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTT CTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGT TACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTG GACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGC CCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTC TTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGG AAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAA GTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAAC AGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAG CCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAG ATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTT TTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGC CTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGT TTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTC AGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTT TGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATA TGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAG AAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTA TGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAATAAATTAAT AAATTTATATAAATTCT |
Protein Sequence | >54658 : length: 533 MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH |