| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5291 |
Name | PIK3CB |
Synonym | P110BETA|PI3K|PI3KBETA|PIK3C1;phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta;PIK3CB;phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
Definition | PI3-kinase p110 subunit beta|PI3-kinase subunit beta|PI3K-beta|PtdIns-3-kinase p110|phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform|phosphatidylino |
Position | 3q22.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Axon guidance mediated by netrin;PANTHER;P00009 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | GPVI-mediated activation cascade;PID Reactome;500294 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Carbohydrate digestion and absorption;KEGG PATHWAY;hsa04973 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | mTOR signaling pathway;KEGG PATHWAY;hsa04150 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | 3-phosphoinositide biosynthesis;BioCyc;PWY-6352 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | diabetes, type 2;GAD |
Disease | METABOLIC;GAD |
External Links | |
Links to Entrez Gene | 5291 |
Links to all GeneRIF Items | 5291 |
Links to iHOP | 5291 |
Sequence Information | |
Nucleotide Sequence | >5291 : length: 5931 GGCCCCGTGGTTATGAATGTGCTTCAGTTTCATAATGCCTCCTGCTATGGCAGACATCCT TGACATCTGGGCGGTGGATTCACAGATAGCATCTGATGGCTCCATACCTGTGGATTTCCT TTTGCCCACTGGGATTTATATCCAGTTGGAGGTACCTCGGGAAGCTACCATTTCTTATAT TAAGCAGATGTTATGGAAGCAAGTTCACAATTACCCAATGTTCAACCTCCTTATGGATAT TGACTCCTATATGTTTGCATGTGTGAATCAGACTGCTGTATATGAGGAGCTTGAAGATGA AACACGAAGACTCTGTGATGTCAGACCTTTTCTTCCAGTTCTCAAATTAGTGACAAGAAG TTGTGACCCAGGGGAAAAATTAGACTCAAAAATTGGAGTCCTTATAGGAAAAGGTCTGCA TGAATTTGATTCCTTGAAGGATCCTGAAGTAAATGAATTTCGAAGAAAAATGCGCAAATT CAGCGAGGAAAAAATCCTGTCACTTGTGGGATTGTCTTGGATGGACTGGCTAAAACAAAC ATATCCACCAGAGCATGAACCATCCATCCCTGAAAACTTAGAAGATAAACTTTATGGGGG AAAGCTCATCGTAGCTGTTCATTTTGAAAACTGCCAGGACGTGTTTAGCTTTCAAGTGTC TCCTAATATGAATCCTATCAAAGTAAATGAATTGGCAATCCAAAAACGTTTGACTATTCA TGGGAAGGAAGATGAAGTTAGCCCCTATGATTATGTGTTGCAAGTCAGCGGGAGAGTAGA ATATGTTTTTGGTGATCATCCACTAATTCAGTTCCAGTATATCCGGAACTGTGTGATGAA CAGAGCCCTGCCCCATTTTATACTTGTGGAATGCTGCAAGATCAAGAAAATGTATGAACA AGAAATGATTGCCATAGAGGCTGCCATAAATCGAAATTCATCTAATCTTCCTCTTCCATT ACCACCAAAGAAAACACGAATTATTTCTCATGTTTGGGAAAATAACAACCCTTTCCAAAT TGTCTTGGTTAAGGGAAATAAACTTAACACAGAGGAAACTGTAAAAGTTCATGTCAGGGC TGGTCTTTTTCATGGTACTGAGCTCCTGTGTAAAACCATCGTAAGCTCAGAGGTATCAGG GAAAAATGATCATATTTGGAATGAACCACTGGAATTTGATATTAATATTTGTGACTTACC AAGAATGGCTCGATTATGTTTTGCTGTTTATGCAGTTTTGGATAAAGTAAAAACGAAGAA ATCAACGAAAACTATTAATCCCTCTAAATATCAGACCATCAGGAAAGCTGGAAAAGTGCA TTATCCTGTAGCGTGGGTAAATACGATGGTTTTTGACTTTAAAGGACAATTGAGAACTGG AGACATAATATTACACAGCTGGTCTTCATTTCCTGATGAACTCGAAGAAATGTTGAATCC AATGGGAACTGTTCAAACAAATCCATATACTGAAAATGCAACAGCTTTGCATGTTAAATT TCCAGAGAATAAAAAACAACCTTATTATTACCCTCCCTTCGATAAGATTATTGAAAAGGC AGCTGAGATTGCAAGCAGTGATAGTGCTAATGTGTCAAGTCGAGGTGGAAAAAAGTTTCT TCCTGTATTGAAAGAAATCTTGGACAGGGATCCCTTGTCTCAACTGTGTGAAAATGAAAT GGATCTTATTTGGACTTTGCGACAAGACTGCCGAGAGATTTTCCCACAATCACTGCCAAA ATTACTGCTGTCAATCAAGTGGAATAAACTTGAGGATGTTGCTCAGCTTCAGGCGCTGCT TCAGATTTGGCCTAAACTGCCCCCCCGGGAGGCCCTAGAGCTTCTGGATTTCAACTATCC AGACCAGTACGTTCGAGAATATGCTGTAGGCTGCCTGCGACAGATGAGTGATGAAGAACT TTCTCAATATCTTTTACAACTGGTGCAAGTGTTAAAATATGAGCCTTTTCTTGATTGTGC CCTCTCTAGATTCCTATTAGAAAGAGCACTTGGTAATCGGAGGATAGGGCAGTTTCTATT TTGGCATCTTAGGTCAGAAGTGCACATTCCTGCTGTCTCAGTACAATTTGGTGTCATCCT TGAAGCATACTGCCGGGGAAGTGTGGGGCACATGAAAGTGCTTTCTAAGCAGGTTGAAGC ACTCAATAAGTTAAAAACTTTAAATAGTTTAATCAAACTGAATGCCGTGAAGTTAAACAG AGCCAAAGGGAAGGAGGCCATGCATACCTGTTTAAAACAGAGTGCTTACCGGGAAGCCCT CTCTGACCTGCAGTCACCCCTGAACCCATGTGTTATCCTCTCAGAACTCTATGTTGAAAA GTGCAAATACATGGATTCCAAAATGAAGCCTTTGTGGCTGGTATACAATAACAAGGTATT TGGTGAGGATTCAGTTGGAGTGATTTTTAAAAATGGTGATGATTTACGACAGGATATGTT GACACTCCAAATGTTGCGCTTGATGGATTTACTCTGGAAAGAAGCTGGTTTGGATCTTCG GATGTTGCCTTATGGCTGTTTAGCAACAGGAGATCGCTCTGGCCTCATTGAAGTTGTGAG CACCTCTGAAACAATTGCTGACATTCAGCTGAACAGTAGCAATGTGGCTGCTGCAGCAGC CTTCAACAAAGATGCCCTTCTGAACTGGCTTAAAGAATACAACTCTGGGGATGACCTGGA CCGAGCCATTGAGGAATTTACACTGTCCTGTGCTGGCTACTGTGTAGCTTCTTATGTCCT TGGGATTGGTGACAGACATAGTGACAACATCATGGTCAAAAAAACTGGCCAGCTCTTCCA CATTGACTTTGGACATATTCTTGGAAATTTCAAATCTAAGTTTGGCATTAAAAGGGAGCG AGTGCCTTTTATTCTTACCTATGATTTCATCCATGTCATTCAACAAGGAAAAACAGGAAA TACAGAAAAGTTTGGCCGGTTCCGCCAGTGTTGTGAGGATGCATATCTGATTTTACGACG GCATGGGAATCTCTTCATCACTCTCTTTGCGCTGATGTTGACTGCAGGGCTTCCTGAACT CACATCAGTCAAAGATATACAGTATCTTAAGGACTCTCTTGCATTAGGGAAGAGTGAAGA AGAAGCACTCAAACAGTTTAAGCAAAAATTTGATGAGGCGCTCAGGGAAAGCTGGACTAC TAAAGTGAACTGGATGGCCCACACAGTTCGGAAAGACTACAGATCTTAACGATCAGCCTT CGCTCCTAATGTATTTGTTGGTTTCATTTCATTTTCATTTTGCACTTGCACTAAATTGAA CATGACCCTGTTAGAGATGTTATAAAGGGAATGAAATCCTGGAACTCAGAGTTAAATTAA GAACAAGGCATCCCACAGAACCTAATCTGAACAATCCCCGATGATTCCCTCTGCTTTTTG AATGCTTCCAAGACTTATCATGAAAACTGTCAATGGATAATCATTTCCTGCTGACTTTGC ACGCCAAGGAATGCTACTAGGGATTGTTTCCGTTTTTGTTTGTTTTTTCTAATATTTGGT ACTTCCCAGAATGGTGTAAATACTTCTTTTCAATGTTGTGACCAAGTATTGTCACTCAGC CAACAACTTTTCCACACCTGGGGGTTGGTGGCTGTTCTTACTGTCCAAATGAAGCTAAAA AGAAAGGCATCTTTCTTCCCTTTTAAAATTGTGTAAACTGCAAATTATAATATAATTTGA ATTTATGATTATTTTCCAGAAGAAATCTTGTAAACCTGTGGATACTCATTAATTCTTTTG TTAATATTTATTTCCATGATAGCATCATTCCAGCCAGACTTGCTGAAAATCTACTGGTGA GGCAAATATAATATATATAAATATGCTACATATATATTTATAAAATTTCTAGTGGGAGTT CTATATAAATGTTTCTTTGGTATTCTTCAGCCTGTGATTTAAAGTTTTACAAAAAGCAGA GCTTTTTCCTAAGTTACTTTTCAGTTAGGTAACTGTGTGATCCAGTTCTTCCAGCTGCTT CTATAATGAGGCACATATTAATACAGTTTTTATATGGTATCTATGAAAGAGTTCACTTCA TAGAGAATAATACTTGAGCAAATGTATCCAAGAAAGCAAGCAAATGAAAAGAAACCTATT TATGGAATAAACTCCAGATCTGAAATTCAGTATTTTAGAAAAATGCCAGCTCTTCTTACT GTATTTATTAAAACTTGTAATAATGTGATTTTTTTCAAGGATATTAGTTCAAATTGAAAT GGTTTCACGCCACACGGAAATCTTTAAGTTATTTGTTGAGGTACCATATATTTAGGGTGC TAGGGGCAAGTAATGTTAATATGTGCAATAGGAACTACTGGTTTGAATGTGTAAATGGGT GATCTCTCTGAGTCCTGGCAACATCCAGCAAAACTACTGCTTATTCTCCAAAGAATATTG GGAGCTCTCAATCCTCGGTGATATGGGAAAGAGAACTGAGTATTTGCCCTATGACTGAGC TTTCTATAGGAATTTTATTAAAGAATGTTTAATTTTGTTGTCCTTCTTAATGTTCTCAGT CAAATAAATGAGTGAGCTGGTTTCGGCTGCTCTTGGAATGGGTGAGCCTCTTCTTTATGG GTAGACTGGGCCTTTGGAACTTGGCACTGGAACTCCAAGAAATGGCCAAGTCAGTAGACA AACCAACCTCAGGAATAGGCTAAGGCTTATTATGGCCTCTTCCCTGACTTCTCCCCTTGT TTCCCAGCCTCATCAGGCATGGTATAGGAGGCCCCCTGGACTTTGGTGGGAGCCTGAGGT AAGGAGCCATGCATATGGGAGGTGTCCTGAAGTCTGGGTAGTTACTTGGCACTGAGCCAA GGCCAGACTCTGCTGCTTTGGAGCTCTTGTTCATGGGGCAGATGCTGGAGCAGTCCAGTT CCTTGGAAATAACTCAGCTGAGGATGGGAGTTGGCCCCTGAATTCCTCATTTCCAGGGCT GGTGTAGACTCACTGAGACTTCCAGGAATAGAACTATGGAAGGACAGGTTTGTTCAGAGA TCTTTGTCTAGTAGCCACCCACCATTTCATGAACCAGGCCGCAGGTCAGTGGTTTGGAGA ATGGTGAACACTGCCAGGAAGAAATGGATACCATTCTTTCCAGAGGGGTCTCCTCAGCCA AAAGGAGGGCCTTGATAAATACATGCCAAATCAGTGAAGTTCAAGTCAACTGTTTTTCCC ATATGGGCACCAAATTGTATCTTTCCTGTTTTCTTTGAAGGGTTAAGTAACGTGACCATA GTCACAGAGTAGTTGATGGAGCCAGTATTCAAACCCAGAAAGTAAGAAGCCTATTTTAAT TATCTGTGCTCTTTACTCACAATGCCTCAGTATACATTTCAGATTTATTGGGTTCCACAA ATAGAAATCTATGGAAATTTTGAATCAAATTGCATTAAGCTATAGACAAGGTTGAGACAA ATTGACATCTCCAGAATATTGAGTTTTCCAAAATATGTAAGTGGAGTACCCATTTATTTA GATTATCTTTCATTTATATCCGCAATGATTTATAGTATTCTGTGTTTACATATTATGCAT CGTTTGTTAGATTCCTGGGTAAGTGACTTTATTGTAAGTTTCATTGTTGTTAATCTATAG CAATCATTCTCCAAGTGTGGTCCCCTGATGAGGAGCATCAGCATCACCAGAGAGAACTGG TTAAAAATGCAAATTCTTAATTTTTAATTTTTGTGAGTACATAGTAGATATATATATGGG GTACATGGAATATTTTGATACAGGCATATAACATGTAATTATCGCATCAGGGTAATTGGG GTATCCATTACCTCAAGCATTTATCCTTTGTATTAGAAACAATCCAGTTATACTCTTTTA GTTATTTTAAGATCTATAATTAAATTATCGACTATAGTTAAAAAAAAAAAA |
Protein Sequence | >5291 : length: 1070 MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS |