| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4436 |
Name | MSH2 |
Synonym | COCA1|FCC1|HNPCC|HNPCC1|LCFS2;mutS homolog 2;MSH2;mutS homolog 2 |
Definition | DNA mismatch repair protein Msh2|hMSH2|mutS homolog 2, colon cancer, nonpolyposis type 1 |
Position | 2p21 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Mismatch repair;KEGG PATHWAY;hsa03430 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Disease | Colorectal cancer;KEGG DISEASE;H00020 |
Disease | Cancers;KEGG DISEASE |
Disease | endometrial cancer;GAD |
Disease | Mismatch repair cancer syndrome;OMIM |
Disease | leukemia;GAD |
Disease | Female reproductive cancer;FunDO |
Disease | Muir-Torre syndrome;OMIM |
Disease | Colorectal cancer, hereditary nonpolyposis, type 1;OMIM |
Disease | CANCER;GAD |
Disease | Ovarian cancer;KEGG DISEASE;H00027 |
Disease | Testicular dysfunction;FunDO |
Disease | Gastritis;FunDO |
Disease | Cancer;FunDO |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Yersinia infection;FunDO |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Lymphoma, Non-Hodgkin;GAD |
Disease | colorectal cancer;GAD |
External Links | |
Links to Entrez Gene | 4436 |
Links to all GeneRIF Items | 4436 |
Links to iHOP | 4436 |
Sequence Information | |
Nucleotide Sequence | >4436 : length: 5315 GGGAGGCGGGAAACAGCTTAGTGGGTGTGGGGTCGCGCATTTTCTTCAACCAGGAGGTGA GGAGGTTTCGACATGGCGGTGCAGCCGAAGGAGACGCTGCAGTTGGAGAGCGCGGCCGAG GTCGGCTTCGTGCGCTTCTTTCAGGGCATGCCGGAGAAGCCGACCACCACAGTGCGCCTT TTCGACCGGGGCGACTTCTATACGGCGCACGGCGAGGACGCGCTGCTGGCCGCCCGGGAG GTGTTCAAGACCCAGGGGGTGATCAAGTACATGGGGCCGGCAGGAGCAAAGAATCTGCAG AGTGTTGTGCTTAGTAAAATGAATTTTGAATCTTTTGTAAAAGATCTTCTTCTGGTTCGT CAGTATAGAGTTGAAGTTTATAAGAATAGAGCTGGAAATAAGGCATCCAAGGAGAATGAT TGGTATTTGGCATATAAGGCTTCTCCTGGCAATCTCTCTCAGTTTGAAGACATTCTCTTT GGTAACAATGATATGTCAGCTTCCATTGGTGTTGTGGGTGTTAAAATGTCCGCAGTTGAT GGCCAGAGACAGGTTGGAGTTGGGTATGTGGATTCCATACAGAGGAAACTAGGACTGTGT GAATTCCCTGATAATGATCAGTTCTCCAATCTTGAGGCTCTCCTCATCCAGATTGGACCA AAGGAATGTGTTTTACCCGGAGGAGAGACTGCTGGAGACATGGGGAAACTGAGACAGATA ATTCAAAGAGGAGGAATTCTGATCACAGAAAGAAAAAAAGCTGACTTTTCCACAAAAGAC ATTTATCAGGACCTCAACCGGTTGTTGAAAGGCAAAAAGGGAGAGCAGATGAATAGTGCT GTATTGCCAGAAATGGAGAATCAGGTTGCAGTTTCATCACTGTCTGCGGTAATCAAGTTT TTAGAACTCTTATCAGATGATTCCAACTTTGGACAGTTTGAACTGACTACTTTTGACTTC AGCCAGTATATGAAATTGGATATTGCAGCAGTCAGAGCCCTTAACCTTTTTCAGGGTTCT GTTGAAGATACCACTGGCTCTCAGTCTCTGGCTGCCTTGCTGAATAAGTGTAAAACCCCT CAAGGACAAAGACTTGTTAACCAGTGGATTAAGCAGCCTCTCATGGATAAGAACAGAATA GAGGAGAGATTGAATTTAGTGGAAGCTTTTGTAGAAGATGCAGAATTGAGGCAGACTTTA CAAGAAGATTTACTTCGTCGATTCCCAGATCTTAACCGACTTGCCAAGAAGTTTCAAAGA CAAGCAGCAAACTTACAAGATTGTTACCGACTCTATCAGGGTATAAATCAACTACCTAAT GTTATACAGGCTCTGGAAAAACATGAAGGAAAACACCAGAAATTATTGTTGGCAGTTTTT GTGACTCCTCTTACTGATCTTCGTTCTGACTTCTCCAAGTTTCAGGAAATGATAGAAACA ACTTTAGATATGGATCAGGTGGAAAACCATGAATTCCTTGTAAAACCTTCATTTGATCCT AATCTCAGTGAATTAAGAGAAATAATGAATGACTTGGAAAAGAAGATGCAGTCAACATTA ATAAGTGCAGCCAGAGATCTTGGCTTGGACCCTGGCAAACAGATTAAACTGGATTCCAGT GCACAGTTTGGATATTACTTTCGTGTAACCTGTAAGGAAGAAAAAGTCCTTCGTAACAAT AAAAACTTTAGTACTGTAGATATCCAGAAGAATGGTGTTAAATTTACCAACAGCAAATTG ACTTCTTTAAATGAAGAGTATACCAAAAATAAAACAGAATATGAAGAAGCCCAGGATGCC ATTGTTAAAGAAATTGTCAATATTTCTTCAGGCTATGTAGAACCAATGCAGACACTCAAT GATGTGTTAGCTCAGCTAGATGCTGTTGTCAGCTTTGCTCACGTGTCAAATGGAGCACCT GTTCCATATGTACGACCAGCCATTTTGGAGAAAGGACAAGGAAGAATTATATTAAAAGCA TCCAGGCATGCTTGTGTTGAAGTTCAAGATGAAATTGCATTTATTCCTAATGACGTATAC TTTGAAAAAGATAAACAGATGTTCCACATCATTACTGGCCCCAATATGGGAGGTAAATCA ACATATATTCGACAAACTGGGGTGATAGTACTCATGGCCCAAATTGGGTGTTTTGTGCCA TGTGAGTCAGCAGAAGTGTCCATTGTGGACTGCATCTTAGCCCGAGTAGGGGCTGGTGAC AGTCAATTGAAAGGAGTCTCCACGTTCATGGCTGAAATGTTGGAAACTGCTTCTATCCTC AGGTCTGCAACCAAAGATTCATTAATAATCATAGATGAATTGGGAAGAGGAACTTCTACC TACGATGGATTTGGGTTAGCATGGGCTATATCAGAATACATTGCAACAAAGATTGGTGCT TTTTGCATGTTTGCAACCCATTTTCATGAACTTACTGCCTTGGCCAATCAGATACCAACT GTTAATAATCTACATGTCACAGCACTCACCACTGAAGAGACCTTAACTATGCTTTATCAG GTGAAGAAAGGTGTCTGTGATCAAAGTTTTGGGATTCATGTTGCAGAGCTTGCTAATTTC CCTAAGCATGTAATAGAGTGTGCTAAACAGAAAGCCCTGGAACTTGAGGAGTTTCAGTAT ATTGGAGAATCGCAAGGATATGATATCATGGAACCAGCAGCAAAGAAGTGCTATCTGGAA AGAGAGAACCTCAGAGTGACAGAGCCAAAAGACCAGTGCCTCATTTTGCTGACATGGAAA AGGAAACTTCGTGGGGGAAAGAGATCTGCTTGCAGTCGGCCAGAGAGACAGAACCAGGGC AGTGCGACTCCAAGTGCATCAGCATAGGCATTGCCAGGAGCTCATGAGGAATGCAGACTG TCAGGTCCCACCCCAGACCTACTCAACAGAAACTACTTGGTAAGCAGATTCCCAGGTGGT TCCAGGCACCTTACAGTTTGAAAAGCACTGCTGCATGCTATCCTACCTTCCTGGTCTGTA ACATCTGTTGCTGTTGAGTATAAAGACACTGTGAACATTGTAAAATCTGCAATTACAAGA TTCTGGATGCTTCATCCTGAGGTCACCTTGGAATGAGATCCTCTGGGATCTGGAGGAAGC AGATGGAGGAGAAACCCCAGGGCTCAATTTTTCTAAGGGCCCAGGCACACCAGTTACCAC TGACCTGCTAGTAAGCCAGGAACTTAGCCCCATGTTGGGGGTTGGCCAAGCGCAGGGAGG AGGCAGCACTCACAAGACAGAGTCCGGAGCATTCTCCACCACAGCCAGTGGCCACTTGGA GAGGGGACCTAGAGTCCCCTGGTAGGTGGCTAGGGAATGGCAGGGTTTGGGGTAGAACTT CCTGGGGCCAGAGTCTCATAGCAGTGGTAGCCAAGAGTTGGCTTAGGGTGAGAGCCAAGG GGCTTCAGTACCCTTCTTCATTCTCTACCAGCACCTCCCCAACCTCCTGGAAACTGCTGT GCTTCCTGCAGTTTCAAGCCCCTCCACCCCCTGTTCCTCACCAACTCTCCCCGTGTAGAA ACTCTGCAGAGAGTATGACCGTGTCTCTTAAAAAAACTTTGGTGAGGATCAGAGGCTGGA CTCTGCCCAAAGCACCCACCTTGGGCTCCACACACTTTCCGGATTGCTGGCTGGTGGCCC CATGCAGAGCCCCCGACCCCGGAAAGTCAGTGGAACTGGACGGAAAAAATGGAAGGGCCA GAAAACTTGGGGAGGACTCCAGAGCTGGGGGTGACACAGGAATAGACCAACGGCCTTTTG TTGTTTCCAAGATCCTCTGAATCTGAGGCAGCCAAACAAGGCATGGGAGTGCTGCTCCAG GTGTCAGGGATGGGTACACTTACTGAACACTTACCCAAGGCTACCACCACCATCTCCAGA TCAAGCAGGAGTTTTTACCCAAAGCCCCCTCACAAGTCACTCAGCCTGCCTTCTGCTCCT CAGATACCCACCCTTCTCTCCAGCTCCTCCCCTCTGTGCGTAGCGCAACACTCACCCCTT CTGGGAAGCCTTGGTGCCCTCTCAGAACTGTACTGGATTCTCTACTTGTCTATGTGAGCA GTGTGTGTGTGTGTCTGTGTGTGCTGTTTGTGTGAGAATTATGTGTGTAAGAAAGGGTGT GGGAGAGTGAGAGAGATACACCTACCTTTGGCAATATTGATGTAACTCTTCTAGGGAGGA TGAGAGCGCAAGCTCTCAGGGAATCCCCCTTTGACTTGCTGGGTAACTTGGGCAACCTCT CCTCCTCTCTGAGCCTTGTGTAAAATGAGGAACAAGGGTAAATTCACCCGCTTTGGGCTG GTCTTGGAGATGCTCTAGGGCTCTTCAGAGAAGACTTCAGGGAGCGGGCGGCAACTGAGG AAAGGCCCACTGGTCCGGACTCCAGCCCCCACCCCTAATTACAGCAGCTCTGCTCCTATT TGCTATAATGGGCTGATTGTTGGCTTTTGTTGACAAAATGGTCTACATGCCTGGGGAAAG TTATGAAGGATCTTTGTGGTGCTTCCAGCTAGAATACTCTAGGAGTGTACCTTTGCTCCA TTCGGCACAATTCTGAGCTGTTCGACGCGGAGGCCCTTGGGCATAGTCAAGACTGAGTGG AAATATGTTCTCTCTCAGCTGGCTTGGCCCAGGAATAGCGGCAGACCATTCCTGGGAGTC CAGGGGAGAGCAGGGGGATCCAGGTACCTTTCTTGTCTCAGTTTTTGATGGCCTGGCAGT GCCCCCACCTGTTTTTTCTTCTTACCTTTCTCCACTCTCCCAGAACTTCCCAAAGGAAGC TGCTCTCATTAAAACAAGGGAGGTTGAAGATCCTAACGCCACAGGCTTGTTCGGGAGGCA GCTCACCTCCTGGAACTGAGTGCAGTCCTGGAGAAAACCAAGTGGATGTGCGGCCCCTTT CCATGGAGCAATTAGGTGGATAACTGTCCAGTCGCTCCTAGGCTTTGTAGAGGCATAGGC TCAGATACAAAGAGACCAGACAGTCTCTCGCTCCAAAGGGGCTGGCCACAAGCACCATGA AGACAGCAGTACCCACTGACTCAGCAATTTCACCAGCTGGAAGTCATCCCAAGGAGATAT CACAGAAAGAAAAGGCCATCTTGCGTAAAGATGATCACTGTGTCATTACTCAAAATAGCC CCAAACTGGGAAACACCCAGCTATCCAGCAATAGGGGTAGTGAATTACAGAACATCAACT AGATGGAATATTATGCACCCACTAAAATTAGACTACGTGAAAACACAGAAACAACATCAG TAATAAAATGTTAATAAAACAGAAGCAGCTCAGTA |
Protein Sequence | >4436 : length: 974 MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKT QGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLA YKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPD NDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD LNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELLSDDSNFGQFELTTFDFSQYM KLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEERL NLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQA LEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFS TVDIQKNGVKFTNSKLTSLNEEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLA QLDAVVSFAHVSNGAPVPYVRPAILEKGQGRIILKASRHACVEVQDEIAFIPNDVYFEKD KQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLK GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMF ATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHV IECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLERENLRVTEPKDQCLILLTWKRKLR GGKRSACSRPERQNQGSGGDFKRKSLVVCKATNPALKWIVPSPLNEFSFIHLEKHSLVLS MELQATSGGAQCPG |