| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4321 |
Name | MMP12 |
Synonym | HME|ME|MME|MMP-12;matrix metallopeptidase 12;MMP12;matrix metallopeptidase 12 |
Definition | macrophage metalloelastase|matrix metallopeptidase 12 (macrophage elastase)|matrix metalloproteinase 12 (macrophage elastase) |
Position | 11q22.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Disease | Endometrial cancer;FunDO |
Disease | gastric cardia adenocarcinoma and esophageal squamous cell carcinoma;GAD |
Disease | Emphysema;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Malignant glioma;FunDO |
Disease | IMMUNE;GAD |
Disease | Lung cancer;FunDO |
Disease | Multiple sclerosis;FunDO |
Disease | Periodontitis;FunDO |
Disease | bladder cancer;GAD |
Disease | CANCER;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | coronary artery luminal dimensions;GAD |
Disease | lung cancer;GAD |
Disease | rheumatoid arthritis;GAD |
Disease | lung function;GAD |
Disease | Endometriosis;FunDO |
Disease | Atherosclerosis;FunDO |
Disease | Cervical cancer;FunDO |
Disease | Chronic obstructive airway disease;FunDO |
Disease | Actinic keratosis;FunDO |
External Links | |
Links to Entrez Gene | 4321 |
Links to all GeneRIF Items | 4321 |
Links to iHOP | 4321 |
Sequence Information | |
Nucleotide Sequence | >4321 : length: 1877 CAGAACCCGGACTAAGGGCTATATAAAGAGGAACAGTTCAGGAACTTAGGCTAGAAAGGA ACACAGTAAACTGAATTGATCCGTTTAGAAGTTTACAATGAAGTTTCTTCTAATACTGCT CCTGCAGGCCACTGCTTCTGGAGCTCTTCCCCTGAACAGCTCTACAAGCCTGGAAAAAAA TAATGTGCTATTTGGTGAAAGATACTTAGAAAAATTTTATGGCCTTGAGATAAACAAACT TCCAGTGACAAAAATGAAATATAGTGGAAACTTAATGAAGGAAAAAATCCAAGAAATGCA GCACTTCTTGGGTCTGAAAGTGACCGGGCAACTGGACACATCTACCCTGGAGATGATGCA CGCACCTCGATGTGGAGTCCCCGATGTCCATCATTTCAGGGAAATGCCAGGGGGGCCCGT ATGGAGGAAACATTATATCACCTACAGAATCAATAATTACACACCTGACATGAACCGTGA GGATGTTGACTACGCAATCCGGAAAGCTTTCCAAGTATGGAGTAATGTTACCCCCTTGAA ATTCAGCAAGATTAACACAGGCATGGCTGACATTTTGGTGGTTTTTGCCCGTGGAGCTCA TGGAGACTTCCATGCTTTTGATGGCAAAGGTGGAATCCTAGCCCATGCTTTTGGACCTGG ATCTGGCATTGGAGGGGATGCACATTTCGATGAGGACGAATTCTGGACTACACATTCAGG AGGCACAAACTTGTTCCTCACTGCTGTTCACGAGATTGGCCATTCCTTAGGTCTTGGCCA TTCTAGTGATCCAAAGGCCGTAATGTTCCCCACCTACAAATATGTTGACATCAACACATT TCGCCTCTCTGCTGATGACATACGTGGCATTCAGTCCCTGTATGGAGACCCAAAAGAGAA CCAACGCTTGCCAAATCCTGACAATTCAGAACCAGCTCTCTGTGACCCCAATTTGAGTTT TGATGCTGTCACTACCGTGGGAAATAAGATCTTTTTCTTCAAAGACAGGTTCTTCTGGCT GAAGGTTTCTGAGAGACCAAAGACCAGTGTTAATTTAATTTCTTCCTTATGGCCAACCTT GCCATCTGGCATTGAAGCTGCTTATGAAATTGAAGCCAGAAATCAAGTTTTTCTTTTTAA AGATGACAAATACTGGTTAATTAGCAATTTAAGACCAGAGCCAAATTATCCCAAGAGCAT ACATTCTTTTGGTTTTCCTAACTTTGTGAAAAAAATTGATGCAGCTGTTTTTAACCCACG TTTTTATAGGACCTACTTCTTTGTAGATAACCAGTATTGGAGGTATGATGAAAGGAGACA GATGATGGACCCTGGTTATCCCAAACTGATTACCAAGAACTTCCAAGGAATCGGGCCTAA AATTGATGCAGTCTTCTACTCTAAAAACAAATACTACTATTTCTTCCAAGGATCTAACCA ATTTGAATATGACTTCCTACTCCAACGTATCACCAAAACACTGAAAAGCAATAGCTGGTT TGGTTGTTAGAAATGGTGTAATTAATGGTTTTTGTTAGTTCACTTCAGCTTAATAAGTAT TTATTGCATATTTGCTATGTCCTCAGTGTACCACTACTTAGAGATATGTATCATAAAAAT AAAATCTGTAAACCATAGGTAATGATTATATAAAATACATAATATTTTTCAATTTTGAAA ACTCTAATTGTCCATTCTTGCTTGACTCTACTATTAAGTTTGAAAATAGTTACCTTCAAA GGCCAAGAGAATTCTATTTGAAGCATGCTCTGTAAGTTGCTTCCTAACATCCTTGGACTG AGAAATTATACTTACTTCTGGCATAACTAAAATTAAGTATATATATTTTGGCTCAAATAA AATTGAAAAAAAAATCA |
Protein Sequence | >4321 : length: 470 MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC |