| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4137 |
Name | MAPT |
Synonym | DDPAC|FTDP-17|MAPTL|MSTD|MTBT1|MTBT2|PPND|PPP1R103|TAU;microtubule-associated protein tau;MAPT;microtubule-associated protein tau |
Definition | G protein beta1/gamma2 subunit-interacting factor 1|PHF-tau|neurofibrillary tangle protein|paired helical filament-tau|protein phosphatase 1, regulatory subunit 103 |
Position | 17q21.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | LKB1 signaling events;PID Curated;200061 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Signaling mediated by p38-gamma and p38-delta;PID Curated;200143 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | deregulation of cdk5 in alzheimers disease;PID BioCarta;100086 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Caspase-mediated cleavage of cytoskeletal proteins;PID Reactome;500271 |
Disease | inherited dementia FTDP-17;GAD |
Disease | Ischemia;FunDO |
Disease | Central nervous system disease;FunDO |
Disease | Supranuclear palsy, progressive;OMIM |
Disease | Alzheimer's disease;GAD |
Disease | Nervous system diseases;KEGG DISEASE |
Disease | Nervous system disease;FunDO |
Disease | Progressive supranuclear palsy;KEGG DISEASE;H00077 |
Disease | Down syndrome;FunDO |
Disease | progressive supranuclear palsy;GAD |
Disease | Depression;FunDO |
Disease | Pick disease;OMIM |
Disease | Brain disease;FunDO |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | Pick's disease;KEGG DISEASE;H00078 |
Disease | Amyotrophic lateral sclerosis;KEGG DISEASE;H00058 |
Disease | Neuropathy;FunDO |
Disease | dementia, frontotemporal;GAD |
Disease | Parkinson's disease;GAD |
Disease | Supranuclear Palsy, Progressive;GAD |
Disease | Dementia, frontotemporal, with or without parkinsonism;OMIM |
Disease | Dental plaque;FunDO |
Disease | Familial atypical progressive supranuclear palsy;GAD |
Disease | frontotemporal dementia and Pick-like 3R and 4R tauopathy;GAD |
Disease | cognitive ability;GAD |
Disease | PSYCH;GAD |
Disease | Tauopathy and respiratory failure;OMIM |
Disease | primary progressive aphasia;GAD |
Disease | Parkinson disease, susceptibility to;OMIM |
Disease | Prion disease;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | Myopathy;FunDO |
Disease | Neurodegenerative disorder;FunDO |
Disease | Hydrocephalus;FunDO |
Disease | Neurodegenerative Diseases;GAD |
Disease | Parkinson's disease;NHGRI |
Disease | Supranuclear palsy, progressive atypical;OMIM |
Disease | Rheumatism;FunDO |
Disease | Neurodegenerative diseases;KEGG DISEASE |
Disease | Behavior disease;FunDO |
External Links | |
Links to Entrez Gene | 4137 |
Links to all GeneRIF Items | 4137 |
Links to iHOP | 4137 |
Sequence Information | |
Nucleotide Sequence | >4137 : length: 6914 CCGGCGCGCGCCCTCGCAGTCACCGCCACCCAACAGCTCCGGCACCAACAGCAGCGCCGC TGCCACCGCCCACCTTCTGCCGCCGCCACCACAGCCACCTTCTCCTCCTCCGCTGTCCTC TCCGTCCTCGCCTCTGTCGACTATCAGGTGAGCTTTGAACCAGGATGGCTGAGCCCCGCC AGGAGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTGGGGGACAGGAAAGATC AGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGACACGGACGCTGGCCTGAAAGAAT CTCCCCTGCAGACCCCCACTGAGGACGGATCTGAGGAACCGGGCTCTGAAACCTCTGATG CTAAGAGCACTCCAACAGCGGAAGATGTGACAGCACCCTTAGTGGATGAGGGAGCTCCCG GCAAGCAGGCTGCCGCGCAGCCCCACACGGAGATCCCAGAAGGAACCACAGCTGAAGAAG CAGGCATTGGAGACACCCCCAGCCTGGAAGACGAAGCTGCTGGTCACGTGACCCAAGAGG AGTTGAGAGTTCCAGGCCGGCAGAGGAAGGCGCCTGAAAGGCCCCTGGCCAATGAGATTA GCGCCCACGTCCAGCCTGGACCCTGCGGAGAGGCCTCTGGGGTCTCTGGGCCGTGCCTCG GGGAGAAAGAGCCAGAAGCTCCCGTCCCGCTGACCGCGAGCCTTCCTCAGCACCGTCCCG TTTGCCCAGCGCCTCCTCCAACAGGAGGCCCTCAGGAGCCCTCCCTGGAGTGGGGACAAA AAGGCGGGGACTGGGCCGAGAAGGGTCCGGCCTTTCCGAAGCCCGCCACCACTGCGTATC TCCACACAGAGCCTGAAAGTGGTAAGGTGGTCCAGGAAGGCTTCCTCCGAGAGCCAGGCC CCCCAGGTCTGAGCCACCAGCTCATGTCCGGCATGCCTGGGGCTCCCCTCCTGCCTGAGG GCCCCAGAGAGGCCACACGCCAACCTTCGGGGACAGGACCTGAGGACACAGAGGGCGGCC GCCACGCCCCTGAGCTGCTCAAGCACCAGCTTCTAGGAGACCTGCACCAGGAGGGGCCGC TGCTGAAGGGGGCAGGGGGCAAAGAGAGGCCGGGGAGCAAGGAGGAGGTGGATGAAGACC GCGACGTCGATGAGTCCTCCCCCCAAGACTCCCCTCCCTCCAAGGCCTCCCCAGCCCAAG ATGGGCGGCCTCCCCAGACAGCCGCCAGAGAAGCCACCAGCATCCCAGGCTTCCCAGCGG AGGGTGCCATCCCCCTCCCTGTGGATTTCCTCTCCAAAGTTTCCACAGAGATCCCAGCCT CAGAGCCCAACGGGCCCAGTGCAGGGCGGGCCAAAGGGCAGGATGCCCCCCTGGAGTTCA CGTTTCACGTGGAAATCACACCCAACGTGCAGAAGGAGCAGGCGCACTCGGAGGAGCATT TGGGAAGGGCTGCATTTCCAGGGGCCCCTGGAGAGGGGCCAGAGGCCCGGGGCCCCTCTT TGGGAGAGGACACAAAAGAGGCTGACCTTCCAGAGCCCTCTGAAAAGCAGCCTGCTGCTG CTCCGCGGGGGAAGCCCGTCAGCTGGGTCCCTCAACTCAAAGCTCGCATGGTCAGTAAAA GCAAAGACGGGACTGGAAGCGATGACAAAAAAGCCAAGACATCCACACGTTCCTCTGCTA AAACCTTGAAAAATAGGCCTTGCCTTAGCCCCAAACACCCCACTCCTGGTAGCTCAGACC CTCTGATCCAACCCTCCAGCCCTGCTGTGTGCCCAGAGCCACCTTCCTCTCCTAAATACG TCTCTTCTGTCACTCCCCGAACTGGCAGTTCTGGAGCAAAGGAGATGAAACTCAAGGGGG CTGATGGTAAAACGAAGATCGCCACACCGCGGGGAGCAGCCCCTCCAGGCCAGAAGGGCC AGGCCAACGCCACCAGGATTCCAGCAAAAACCCCACCCGCTCCAAAGACACCACCCAGCT CTGGTGAACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCCCCAGGCA CTCCCGGCAGCCGCTCCCGCACCCCGTCCCTTCCAACCCCACCCACCCGGGAGCCCAAGA AGGTGGCGGTGGTCCGTACTCCACCCAAGTCGCCGTCTTCCGCCAAGAGCCGCCTGCAGA CAGCCCCCGTGCCCATGCCAGACCTGAAGAACGTCAAGTCCAAGATCGGCTCCACTGAGA ACCTGAAGCACCAGCCGGGAGGCGGGAAGGTGCAGATAATTAATAAGAAGCTGGATCTTA GCAACGTCCAGTCCAAGTGTGGCTCAAAGGATAATATCAAACACGTCCCGGGAGGCGGCA GTGTGCAAATAGTCTACAAACCAGTTGACCTGAGCAAGGTGACCTCCAAGTGTGGCTCAT TAGGCAACATCCATCATAAACCAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGAAGCTTG ACTTCAAGGACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTG GCGGAGGAAATAAAAAGATTGAAACCCACAAGCTGACCTTCCGCGAGAACGCCAAAGCCA AGACAGACCACGGGGCGGAGATCGTGTACAAGTCGCCAGTGGTGTCTGGGGACACGTCTC CACGGCATCTCAGCAATGTCTCCTCCACCGGCAGCATCGACATGGTAGACTCGCCCCAGC TCGCCACGCTAGCTGACGAGGTGTCTGCCTCCCTGGCCAAGCAGGGTTTGTGATCAGGCC CCTGGGGCGGTCAATAATCGTGGAGAGGAGAGAATGAGAGAGTGTGGAAAAAAAAAGAAT AATGACCCGGCCCCCGCCCTCTGCCCCCAGCTGCTCCTCGCAGTTCGGTTAATTGGTTAA TCACTTAACCTGCTTTTGTCACTCGGCTTTGGCTCGGGACTTCAAAATCAGTGATGGGAG TAAGAGCAAATTTCATCTTTCCAAATTGATGGGTGGGCTAGTAATAAAATATTTTAAAAA AAAACATTCAAAAACATGGCCACATCCAACATTTCCTCAGGCAATTCCTTTTGATTCTTT TTTCTTCCCCCCTCCATGTAGAAGAGGGGGAAGGAGAGGCTCTGAAAGCTGCTTCTGGGG GATTTCAAGGGACTGGGGGTGCCAACCACCTCTGGCCCTGTTGTGGGGGTGTCACAGAGG CAGTGGCAGCAACAAAGGATTTGAAACTTGGTGTGTTCGTGGAGCCACAGGCAGACGATG TCAACCTTGTGTGAGTGTGACGGGGGTTGGGGTGGGGCGGGAGGCCACGGGGGAGGCCGA GGCAGGGGCTGGGCAGAGGGGAGAGGAAGCACAAGAAGTGGGAGTGGGAGAGGAAGCCAC GTGCTGGAGAGTAGACATCCCCCTCCTTGCCGCTGGGAGAGCCAAGGCCTATGCCACCTG CAGCGTCTGAGCGGCCGCCTGTCCTTGGTGGCCGGGGGTGGGGGCCTGCTGTGGGTCAGT GTGCCACCCTCTGCAGGGCAGCCTGTGGGAGAAGGGACAGCGGGTAAAAAGAGAAGGCAA GCTGGCAGGAGGGTGGCACTTCGTGGATGACCTCCTTAGAAAAGACTGACCTTGATGTCT TGAGAGCGCTGGCCTCTTCCTCCCTCCCTGCAGGGTAGGGGGCCTGAGTTGAGGGGCTTC CCTCTCTGCTCCACAGAAACCCTGTTTTATTGAGTTCTGAAGGTTGGAACTGCTGCCATG ATTTTGGCCACTTTGCAGACCTGGGACTTTAGGGCTAACCAGTTCTCTTTGTAAGGACTT GTGCCTCTTGGGAGACGTCCACCCGTTTCCAAGCCTGGGCCACCGGCATCTCTGGAGTGT GTGGGGGTCTGGGAGGCGGGTCCCGAGCCCCCTGTCCTTCCCACGGCCACTGCAGTCACC CCTGTCTGCCCCGCTGTGCTGTTGTCTGCCGTGAGAGCCCAATCACTGCCTATACCCCTC ATCACGTCACAATGTCCCGAATTCCCAGCCTCACCACCCCTTCTCAGTAATGACCCTGGT TGGTTGCAGGAGGTACCTACTCCATACTGAGGGTGAAATTAAGGGAAGGCAAAGTCCAGG CACCAGAGTGGGACCCCAGCCTCTCACTCTCAGTTCCACTCATCCAACTGGGACCCTCAC CACGAATCTCACGATCTGATTCGGTTCCCTGTCTCCTCCTCCCGTCACAGATGTGAGCCA GGGCACTGCTCAGCTGTGACCCTAGGTGTTTCTGCCTTGTTGACATGGAGAGAGCCCTTT CCCCTGAGAAGGCCTGGCCCCTTCCTGTGCTGAGCCCACAGCAGCAGGCTGGGTGTCTTG GTTGTCAGTGGTGGCACCAGGATGGAAGGGCAAGGCACCCAGGGCAGGCCCACAGTCCCG CTGTCCCCCACTTGCACCCTAGCTTGTAGCTGCCAACCTCCCAGACAGCCCAGCCCGCTG CTCAGCTCCACATGCATAGTATCAGCCCTCCACACCCGACAAAGGGGAACACACCCCCTT GGAAATGGTTCTTTCCCCCCAGTCCCAGCTGGAAGCCATGCTGTCTGTTCTGCTGGAGCA GCTGAACATATACATAGATGTTGCCCTGCCCTCCCCATCTGCACCCTGTTGAGTTGTAGT TGGATTTGTCTGTTTATGCTTGGATTCACCAGAGTGACTATGATAGTGAAAAGAAAAAAA AAAAAAAAAAAAGGACGCATGTATCTTGAAATGCTTGTAAAGAGGTTTCTAACCCACCCT CACGAGGTGTCTCTCACCCCCACACTGGGACTCGTGTGGCCTGTGTGGTGCCACCCTGCT GGGGCCTCCCAAGTTTTGAAAGGCTTTCCTCAGCATCTGGGACCCAACAGAGACCAGCTT CTAGCAGCTAAGGAGGCCGTTCAGCTGTGACGAAGGCCTGAAGCACAGGATTAGGACTGA AGCGATGATGTCCCCTTCCCTACTTCCCCTTGGGGCTCCCTGTGTCAGGGCACAGACTAG GTCTTGTGGCTGGTCTGGCTTGCGGCGCGAGGATGGTTCTCTCTGGTCATAGCCCGAAGT CTCACAGCAGTCCCAAAGGAGGCTTACAACTCCTGCATCACAAGAAAAAGGAAGCCACTG CCAGCTGGGGGGATCTGCAGCTCCCAGAAGCTCCGTGAGCCTCAGCCTACCCCTCAGACT GGGTTCCTCTCCAAGCTCGCCCTCTGGAGGGGCAGCGCAGCCTCCCACCAAGGGCCCTGC GACCACAGCAGGGATTGGGATGAATTGCCTGTCCTGGATCTGCTCTAGAGGCCCAAGCTG CCTGCCTGAGGAAGGATGACTTGACAAGTCAGGAGACACTGTTCCCAAAGCCTTGACCAG AGCACCTCAGCCCGCTGACCTTGCACAAACTCCATCTGCTGCCATGAGAAAAGGGAAGCC GCCTTTGCAAAACATTGCTGCCTAAAGAAACTCAGCAGCCTCAGGCCCAATTCTGCCACT TCTGGTTTGGGTACAGTTAAAGGCAACCCTGAGGGACTTGCAGTAGAAATCCAGGGCCTC CCCTGGGGCTGGCAGCTTCGTGTGCAGCTAGAGCTTTACCTGCAAGGAAGTCTCTGGGCC CAGAACTCTCCACCAAGAGCCTCCCTGCCGTTCGCTGAGTCCCAGCAATTCTAAGTTGAA GGGATCTGAGAAGGAGAAGGAAATGTGGGGTAGATTTGGTGGTGGTTAGAGATATGCCCC CCTCATTACTGCCAACAGTTTCGGCCGCATTTCTTCACGCACCTCGGTTCCTCTTCCTGA AGTTCTTGTGCCCTGCTCTTCAGCACCATGGGCCTTATACGGAAGGCTCTGGGATCTCCC CCTTGTGGGGCAGGCTCTTGGGGCCAGCCTAAGATCATGGTTTAGGGTGATCAGTGCTGG CAGATAAATTGAAAAGGCACGCTGGCTTGTGATCTTAAATGAGGACAATCCCCCCAGGGC TGGGCACTCCTCCCCTCCCCTCACTTCTCCCACCTGCAGAGCCAGTGTCCTTGGGTGGGC TAGATAGGATATACTGTATGCCGGCTCCTTCAAGCTGCTGACTCACTTTATCAATAGTTC CATTTAAATTGACTTCAGTGGTGAGACTGTATCCTGTTTGCTATTGCTTGTTGTGCTATG GGGGGAGGGGGGAGGAATGTGTAAGATAGTTAACATGGGCAAAGGGAGATCTTGGGGTGC AGCACTTAAACTGCCTCGTAACCCTTTTCATGATTTCAACCACATTTGCTAGAGGGAGGG AGCAGCCACGGAGTTAGAGGCCCTTGGGGTTTCTCTTTTCCACTGACAGGCTTTCCCAGG CAGCTGGCTAGTTCATTCCCTCCCCAGCCAGGTGCAGGCGTAGGAATATGGACATCTGGT TGCTTTGGCCTGCTGCCCTCTTTCAGGGGTCCTAAGCCCACAATCATGCCTCCCTAAGAC CTTGGCATCCTTCCCTCTAAGCCGTTGGCACCTCTGTGCCACCTCTCACACTGGCTCCAG ACACACAGCCTGTGCTTTTGGAGCTGAGATCACTCGCTTCACCCTCCTCATCTTTGTTCT CCAAGTAAAGCCACGAGGTCGGGGCGAGGGCAGAGGTGATCACCTGCGTGTCCCATCTAC AGACCTGCGGCTTCATAAAACTTCTGATTTCTCTTCAGCTTTGAAAAGGGTTACCCTGGG CACTGGCCTAGAGCCTCACCTCCTAATAGACTTAGCCCCATGAGTTTGCCATGTTGAGCA GGACTATTTCTGGCACTTGCAAGTCCCATGATTTCTTCGGTAATTCTGAGGGTGGGGGGA GGGACATGAAATCATCTTAGCTTAGCTTTCTGTCTGTGAATGTCTATATAGTGTATTGTG TGTTTTAACAAATGATTTACACTGACTGTTGCTGTAAAAGTGAATTTGGAAATAAAGTTA TTACTCTGATTAAA |
Protein Sequence | >4137 : length: 862 MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG HVTQEELRVPGRQRKAPERPLANEISAHVQPGPCGEASGVSGPCLGEKEPEAPVPLTASL PQHRPVCPAPPPTGGPQEPSLEWGQKGGDWAEKGPAFPKPATTAYLHTEPESGKVVQEGF LREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDL HQEGPLLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSI PGFPAEGAIPLPVDFLSKVSTEIPASEPNGPSAGRAKGQDAPLEFTFHVEITPNVQKEQA HSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSWVPQLKA RMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPP SSPKYVSSVTPRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAP KTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSA KSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKH VPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDN ITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDM VDSPQLATLADEVSASLAKQGL |