| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 335 |
Name | APOA1 |
Synonym | apolipoprotein A-I;APOA1;apolipoprotein A-I |
Definition | apo-AI |
Position | 11q23-q24 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Lipoprotein metabolism;PID Reactome;500795 |
Pathway | Chylomicron-mediated lipid transport;PID Reactome;500796 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | mechanism of gene regulation by peroxisome proliferators via ppara;PID BioCarta;100066 |
Pathway | ABC-family proteins mediated transport;PID Reactome;500331 |
Pathway | FOXA2 and FOXA3 transcription factor networks;PID Curated;200073 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | Transmembrane transport of small molecules;Reactome;REACT:15518 |
Pathway | PPAR signaling pathway;KEGG PATHWAY;hsa03320 |
Pathway | HDL-mediated lipid transport;PID Reactome;500797 |
Disease | hyperlipidemia;GAD |
Disease | Polyneuropathy;FunDO |
Disease | LDL cholesterol;GAD |
Disease | Cardiovascular disease;FunDO |
Disease | Alzheimer's disease;GAD |
Disease | triglycerides;GAD |
Disease | cardiovascular;GAD |
Disease | Lung cancer;FunDO |
Disease | cholesterol, HDL;GAD |
Disease | carotid atherosclerosis;GAD |
Disease | cholesterol, total;GAD |
Disease | Cholelithiasis;FunDO |
Disease | hyperalphalipoproteinemia;GAD |
Disease | Liver cancer;FunDO |
Disease | reduced expression of the apolipoprotein A-I gene and resolution of disputed paternity;GAD |
Disease | Immunologic deficiency syndrome;FunDO |
Disease | cardiac and cutaneous amyloidosis;GAD |
Disease | Triglycerides;NHGRI |
Disease | stroke, ischemic;GAD |
Disease | Lp(a);GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | IMMUNE;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | decreased production rate of apolipoprotein A-I;GAD |
Disease | elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations;GAD |
Disease | METABOLIC;GAD |
Disease | Schizophrenia;FunDO |
Disease | Yersinia infection;FunDO |
Disease | Colon cancer;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | Corneal clouding, autosomal recessive;OMIM |
Disease | Amyloidosis, 3 or more types;OMIM |
Disease | Drug abuse;FunDO |
Disease | lipoprotein;GAD |
Disease | brain aneurysm;GAD |
Disease | diabetes, type 2;GAD |
Disease | stroke, hemorrhagic;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | hypercholesterolemia;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Adenovirus infection;FunDO |
Disease | apolipoprotein A-I levels;GAD |
Disease | Hyperuricemia;FunDO |
Disease | HDL cholesterol;NHGRI |
Disease | reduced HDL cholesterol and LpA-I;GAD |
Disease | gallstones;GAD |
Disease | HDL cholesterol;GAD |
Disease | plasma high density lipoprotein cholesterol and apolipoprotein AI;GAD |
Disease | lipids;GAD |
Disease | Aortic valve disease;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | premature coronary artery disease and familial hypoalphalipoproteinemia;GAD |
Disease | cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides;GAD |
Disease | ApoA-I and apoC-III deficiency, combined;OMIM |
Disease | Hepatitis B;FunDO |
Disease | Hyperlipidemia;FunDO |
Disease | LDL cholesterol;NHGRI |
Disease | elevated serum apolipoprotein AI levels;GAD |
Disease | multiple sclerosis;GAD |
Disease | cerebral infarct;GAD |
Disease | Liver tumor;FunDO |
Disease | Hypoalphalipoproteinemia;OMIM |
Disease | Gallbladder disease;FunDO |
Disease | Amyloidosis;FunDO |
Disease | familial combined hyperlipidaemia.;GAD |
Disease | coronary atherosclerosis;GAD |
Disease | Cholesterol, total;NHGRI |
Disease | Atherosclerosis;GAD |
Disease | myocardial infarct;GAD |
Disease | cholesterol, LDL;GAD |
Disease | Metastatic cancer to brain;FunDO |
External Links | |
Links to Entrez Gene | 335 |
Links to all GeneRIF Items | 335 |
Links to iHOP | 335 |
Sequence Information | |
Nucleotide Sequence | >335 : length: 970 TAGGCCCTGCAAGAGCTGGCTGCTTAGAGACTGCGAGAAGGAGGTGCGTCCTGCTGCCTG CCCCGGTCACTCTGGCTCCCCAGCTCAAGGTCCCCCACGGCCCTTCAGGATGAAAGCTGC GGTGCTGACCTTGGCCGTGCTCTTCCTGACGGGGAGCCAGGCTCGGCATTTCTGGCAGCA AGATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACTGTGTACGTGGA TGTGCTCAAAGACAGCGGCAGAGACTATGTGTCCCAGTTTGAAGGCTCCGCCTTGGGAAA ACAGCTAAACCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACCTTCAGCAAGCT GCGCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAAAAGGAGACAGA GGGCCTGAGGCAGGAGATGAGCAAGGATCTGGAGGAGGTGAAGGCCAAGGTGCAGCCCTA CCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGCCAGAAGGTGGA GCCGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAGCTGCAAGAGAA GCTGAGCCCACTGGGCGAGGAGATGCGCGACCGCGCGCGCGCCCATGTGGACGCGCTGCG CACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCGCGCCTTGAGGC TCTCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCCACCGAGCATCT GAGCACGCTCAGCGAGAAGGCCAAGCCCGCGCTCGAGGACCTCCGCCAAGGCCTGCTGCC CGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTACACTAAGAAGCT CAACACCCAGTGAGGCGCCCGCCGCCGCCCCCCTTCCCGGTGCTCAGAATAAACGTTTCC AAAGTGGGAA |
Protein Sequence | >335 : length: 267 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ GLLPVLESFKVSFLSALEEYTKKLNTQ |