| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 317 |
Name | APAF1 |
Synonym | APAF-1|CED4;apoptotic peptidase activating factor 1;APAF1;apoptotic peptidase activating factor 1 |
Definition | apoptotic protease-activating factor 1 |
Position | 12q23 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Formation of apoptosome;PID Reactome;500886 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | apoptotic signaling in response to dna damage;PID BioCarta;100204 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | stress induction of hsp regulation;PID BioCarta;100142 |
Pathway | Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014 |
Pathway | west nile virus;PID BioCarta;100001 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | role of mitochondria in apoptotic signaling;PID BioCarta;100106 |
Pathway | caspase cascade in apoptosis;PID BioCarta;100218 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Parkinson's disease;KEGG PATHWAY;hsa05012 |
Disease | Cancer;FunDO |
Disease | Depression;FunDO |
Disease | Intestinal disease;FunDO |
External Links | |
Links to Entrez Gene | 317 |
Links to all GeneRIF Items | 317 |
Links to iHOP | 317 |
Sequence Information | |
Nucleotide Sequence | >317 : length: 7204 AAGAAGAGGTAGCGAGTGGACGTGACTGCTCTATCCCGGGCAAAAGGGATAGAACCAGAG GTGGGGAGTCTGGGCAGTCGGCGACCCGCGAAGACTTGAGGTGCCGCAGCGGCATCCGGA GTAGCGCCGGGCTCCCTCCGGGGTGCAGCCGCCGTCGGGGGAAGGGCGCCACAGGCCGGG AAGACCTCCTCCCTTTGTGTCCAGTAGTGGGGTCCACCGGAGGGCGGCCCGTGGGCCGGG CCTCACCGCGGCGCTCCGGGACTGTGGGGTCAGGCTGCGTTGGGTGGACGCCCACCTCGC CAACCTTCGGAGGTCCCTGGGGGTCTTCGTGCGCCCCGGGGCTGCAGAGATCCAGGGGAG GCGCCTGTGAGGCCCGGACCTGCCCCGGGGCGAAGGGTATGTGGCGAGACAGAGCCCTGC ACCCCTAATTCCCGGTGGAAAACTCCTGTTGCCGTTTCCCTCCACCGGCCTGGAGTCTCC CAGTCTTGTCCCGGCAGTGCCGCCCTCCCCACTAAGACCTAGGCGCAAAGGCTTGGCTCA TGGTTGACAGCTCAGAGAGAGAAAGATCTGAGGGAAGATGGATGCAAAAGCTCGAAATTG TTTGCTTCAACATAGAGAAGCTCTGGAAAAGGACATCAAGACATCCTACATCATGGATCA CATGATTAGTGATGGATTTTTAACAATATCAGAAGAGGAAAAAGTAAGAAATGAGCCCAC TCAACAGCAAAGAGCAGCTATGCTGATTAAAATGATACTTAAAAAAGATAATGATTCCTA CGTATCATTCTACAATGCTCTACTACATGAAGGATATAAAGATCTTGCTGCCCTTCTCCA TGATGGCATTCCTGTTGTCTCTTCTTCCAGTGGTAAAGATTCAGTTAGTGGAATAACTTC GTATGTAAGGACAGTCCTGTGTGAAGGTGGAGTACCACAGAGGCCAGTTGTTTTTGTCAC AAGGAAGAAGCTGGTGAATGCAATTCAGCAGAAGCTCTCCAAATTGAAAGGTGAACCAGG ATGGGTCACCATACATGGAATGGCAGGCTGTGGGAAGTCTGTATTAGCTGCAGAAGCTGT TAGAGATCATTCCCTTTTAGAAGGTTGTTTCCCAGGGGGAGTGCATTGGGTTTCAGTTGG GAAACAAGACAAATCTGGGCTTCTGATGAAACTGCAGAATCTTTGCACACGGTTGGATCA GGATGAGAGTTTTTCCCAGAGGCTTCCACTTAATATTGAAGAGGCTAAAGACCGTCTCCG CATTCTGATGCTTCGCAAACACCCAAGGTCTCTCTTGATCTTGGATGATGTTTGGGACTC TTGGGTGTTGAAAGCTTTTGACAGTCAGTGTCAGATTCTTCTTACAACCAGAGACAAGAG TGTTACAGATTCAGTAATGGGTCCTAAATATGTAGTCCCTGTGGAGAGTTCCTTAGGAAA GGAAAAAGGACTTGAAATTTTATCCCTTTTTGTTAATATGAAGAAGGCAGATTTGCCAGA ACAAGCTCATAGTATTATAAAAGAATGTAAAGGCTCTCCCCTTGTAGTATCTTTAATTGG TGCACTTTTACGTGATTTTCCCAATCGCTGGGAGTACTACCTCAAACAGCTTCAGAATAA GCAGTTTAAGAGAATAAGGAAATCTTCGTCTTATGATTATGAGGCTCTAGATGAAGCCAT GTCTATAAGTGTTGAAATGCTCAGAGAAGACATCAAAGATTATTACACAGATCTTTCCAT CCTTCAGAAGGACGTTAAGGTGCCTACAAAGGTGTTATGTATTCTCTGGGACATGGAAAC TGAAGAAGTTGAAGACATACTGCAGGAGTTTGTAAATAAGTCTCTTTTATTCTGTGATCG GAATGGAAAGTCGTTTCGTTATTATTTACATGATCTTCAAGTAGATTTTCTTACAGAGAA GAATTGCAGCCAGCTTCAGGATCTACATAAGAAGATAATCACTCAGTTTCAGAGATATCA CCAGCCGCATACTCTTTCACCAGATCAGGAAGACTGTATGTATTGGTACAACTTTCTGGC CTATCACATGGCCAGTGCCAAGATGCACAAGGAACTTTGTGCTTTAATGTTTTCCCTGGA TTGGATTAAAGCAAAAACAGAACTTGTAGGCCCTGCTCATCTGATTCATGAATTTGTGGA ATACAGACATATACTAGATGAAAAGGATTGTGCAGTCAGTGAGAATTTTCAGGAGTTTTT ATCTTTAAATGGACACCTTCTTGGACGACAGCCATTTCCTAATATTGTACAACTGGGTCT CTGTGAGCCGGAAACTTCAGAAGTTTATCAGCAAGCTAAGCTGCAGGCCAAGCAGGAGGT CGATAATGGAATGCTTTACCTGGAATGGATAAACAAAAAAAACATCACGAATCTTTCCCG CTTAGTTGTCCGCCCCCACACAGATGCTGTTTACCATGCCTGCTTTTCTGAGGATGGTCA GAGAATAGCTTCTTGTGGAGCTGATAAAACCTTACAGGTGTTCAAAGCTGAAACAGGAGA GAAACTTCTAGAAATCAAGGCTCATGAGGATGAAGTGCTTTGTTGTGCATTCTCTACAGA TGACAGATTTATAGCAACCTGCTCAGTGGATAAAAAAGTGAAGATTTGGAATTCTATGAC TGGGGAACTAGTACACACCTATGATGAGCACTCAGAGCAAGTCAATTGCTGCCATTTCAC CAACAGTAGTCATCATCTTCTCTTAGCCACTGGGTCAAGTGACTGCTTCCTCAAACTTTG GGATTTGAATCAAAAAGAATGTCGAAATACCATGTTTGGTCATACAAATTCAGTCAATCA CTGCAGATTTTCACCAGATGATAAGCTTTTGGCTAGTTGTTCAGCTGATGGAACCTTAAA GCTTTGGGATGCGACATCAGCAAATGAGAGGAAAAGCATTAATGTGAAACAGTTCTTCCT AAATTTGGAGGACCCTCAAGAGGATATGGAAGTGATAGTGAAGTGTTGTTCGTGGTCTGC TGATGGTGCAAGGATAATGGTGGCAGCAAAAAATAAAATCTTTCTTTTTGACATTCATAC TAGTGGCCTATTGGGAGAAATCCACACGGGCCATCACAGCACCATCCAGTACTGTGACTT CTCCCCACAAAACCATTTGGCAGTGGTTGCTTTGTCCCAGTACTGTGTAGAGTTGTGGAA TACAGACTCACGTTCAAAGGTGGCTGATTGCAGAGGACATTTAAGTTGGGTTCATGGTGT GATGTTTTCTCCTGATGGATCATCATTTTTGACATCTTCTGATGACCAGACAATCAGGCT CTGGGAGACAAAGAAAGTATGTAAGAACTCTGCTGTAATGTTAAAGCAAGAAGTAGATGT TGTGTTTCAAGAAAATGAAGTGATGGTCCTTGCAGTTGACCATATAAGACGTCTGCAACT CATTAATGGAAGAACAGGTCAGATTGATTATCTGACTGAAGCTCAAGTTAGCTGCTGTTG CTTAAGTCCACATCTTCAGTACATTGCATTTGGAGATGAAAATGGAGCCATTGAGATTTT AGAACTTGTAAACAATAGAATCTTCCAGTCCAGGTTTCAGCACAAGAAAACTGTATGGCA CATCCAGTTCACAGCCGATGAGAAGACTCTTATTTCAAGTTCTGATGATGCTGAAATTCA GGTATGGAATTGGCAATTGGACAAATGTATCTTTCTACGAGGCCATCAGGAAACAGTGAA AGACTTTAGACTCTTGAAAAATTCAAGACTGCTTTCTTGGTCATTTGATGGAACAGTGAA GGTATGGAATATTATTACTGGAAATAAAGAAAAAGACTTTGTCTGTCACCAGGGTACAGT ACTTTCTTGTGACATTTCTCACGATGCTACCAAGTTTTCATCTACCTCTGCTGACAAGAC TGCAAAGATCTGGAGTTTTGATCTCCTTTTGCCACTTCATGAATTGAGGGGCCACAACGG CTGTGTGCGCTGCTCTGCCTTCTCTGTGGACAGTACCCTGCTGGCAACGGGAGATGACAA TGGAGAAATCAGGATATGGAATGTCTCAAACGGTGAGCTTCTTCATTTGTGTGCTCCGCT TTCAGAAGAAGGAGCTGCTACCCATGGAGGCTGGGTGACTGACCTTTGCTTTTCTCCAGA TGGCAAAATGCTTATCTCTGCTGGAGGATATATTAAGTGGTGGAACGTTGTCACTGGGGA ATCCTCACAGACCTTCTACACAAATGGAACCAATCTTAAGAAAATACACGTGTCCCCTGA CTTCAAAACATATGTGACTGTGGATAATCTTGGTATTTTATATATTTTACAGACTTTAGA ATAAAATAGTTAAGCATTAATGTAGTTGAACTTTTTAAATTTTTGAATTGGAAAAAAATT CTAATGAAACCCTGATATCAACTTTTTATAAAGCTCTTAATTGTTGTGCAGTATTGCATT CATTACAAAAGTGTTTGTGGTTGGATGAATAATATTAATGTAGCTTTTTCCCAAATGAAC ATACCTTTAATCTTGTTTTTCATGATCATCATTAACAGTTTGTCCTTAGGATGCAAATGA AAATGTGAATACATACCTTGTTGTACTGTTGGTAAAATTCTGTCTTGATGCATTCAAAAT GGTTGACATAATTAATGAGAAGAATTTGGAAGAAATTGGTATTTTAATACTGTCTGTATT TATTACTGTTATGCAGGCTGTGCCTCAGGGTAGCAGTGGCCTGCTTTTTGAACCACACTT ACCCCAAGGGGGTTTTGTTCTCCTAAATACAATCTTAGAGGTTTTTTGCACTCTTTAAAT TTGCTTTAAAAATATTGTGTCTGTGTGCATAGTCTGCAGCATTTCCTTTAATTGACTCAA TAAGTGAGTCTTGGATTTAGCAGGCCCCCCCACCTTTTTTTTTTGTTTTTGGAGACAGAG TCTTGCTTTGTTGCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACCACAATCGCTGC CTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGTG CGCACATGCCAGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCG GGATGGTCTCGATCTCTTGACCTCATGATCTACCCGCCTTGGCCTCCCAAAGTGCTGAGA TTACAGGCGTGAGCCACCGTGCCTGGCCAGGCCCCTTCTCTTTTAATGGAGACAGGGTCT TGCACTATCACCCAGGCTGGAGTGCAGTGGCATAATCATACCTCATTGCAGCCTCAGACT CCTGGGTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAGTAGCTGAGACTACAGGCACGAG CCACCACACCCAGCTAATTTTTAAGTTTTCTTGTAGAGACAGGGTCTCACTATGTTGTCT AGGCTGGTCTTGAACTCTTGGCCTCAAGTAATCCTCCTGCCTCAGCCTCCCAAAGTGTTG GGATTGCAGATATGAGCCACTGGCCTGGCCTTCAGCAGTTCTTTTTGTGAAGTAAAACTT GTATGTTGGAAAGAGTAGATTTTATTGGTCTACCCTTTTCTCACTGTAGCTGCTGGCAGC CCTGTGCCATATCTGGACTCTAGTTGTCAGTATCTGAGTTGGACACTATTCCTGCTCCCT CTTGTTTCTTACATATCAGACTTCTTACTTGAATGAAACCTGATCTTTCCTAATCCTCAC TTTTTTCTTTTTTAAAAAGCAGTTTCTCCACTGCTAAATGTTAGTCATTGAGGTGGGGCC AATTTTAATCATAAGCCTTAATAAGATTTTTCTAAGAAATGTGAAATAGAACAATTTTCA TCTAATTCCATTTACTTTTAGATGAATGGCATTGTGAATGCCATTCTTTTAATGAATTTC AAGAGAATTCTCTGGTTTTCTGTGTAATTCCAGATGAGTCACTGTAACTCTAGAAGATTA ACCTTCCAGCCAACCTATTTTCCTTTCCCTTGTCTCTCTCATCCTCTTTTCCTTCCTTCT TTCCTTTCTCTTCTTTTATCTCCAAGGTTAATCAGGAAAAATAGCTTTTGACAGGGGAAA AAACTCAATAACTAGCTATTTTTGACCTCCTGATCAGGAACTTTAGTTGAAGCGTAAATC TAAAGAAACATTTTCTCTGAAATATATTATTAAGGGCAATGGAGATAAATTAATAGTAGA TGTGGTTCCCAGAAAATATAATCAAAATTCAAAGATTTTTTTTGTTTCTGTAACTGGAAC TAAATCAAATGATTACTAGTGTTAATAGTAGATAACTTGTTTTTATTGTTGGTGCATATT AGTATAACTGTGGGGTAGGTCGGGGAGAGGGTAAGGGAATAGATCACTCAGATGTATTTT AGATAAGCTATTTAGCCTTTGATGGAATCATAAATACAGTGAATACAATCCTTTGCATTG TTAAGGAGGTTTTTTGTTTTTAAATGGTGGGTCAAGGAGCTAGTTTACAGGCTTACTGTG ATTTAAGCAAATGTGAAAAGTGAAACCTTAATTTTATCAAAAGAAATTTCTGTAAATGGT ATGTCTCCTTAGAATACCCAAATCATAATTTTATTTGTACACACTGTTAGGGGCTCATCT CATGTAGGCAGAGTATAAAGTATTACCTTTTGGAATTAAAAGCCACTGACTGTTATAAAG TATAACAACACACATCAGGTTTTAAAAAGCCTTGAATGGCCCTTGTCTTAAAAAGAAATT AGGAGCCAGGTGCGGTGGCACGTGCCTGTAATCCCAGCTCCTTGGGAGGCTAAGACAGGA GGATTCCTTGAGCCCTGGAGTTTGAGTCCAGCCTGGGTGACATAGCAAGACCCTGTCTTA AAAGAAAAATGGGAAGAAAGACAAGGTAACATGAAGAAAGAAGAGATACCTAGTATGATG GAGCTGCAAATTTCATGGCAGTTCATGCAGTCGGTCAAGAGGAGGATTTTGTTTTGTAGT TTGCAGATGAGCATTTCTAAAGCATTTTCCCTTGCTGTATTTTTTTGTATTATAAATTAC ATTGGACTTCATATATATAATTTTTTTTTACATTATATGTCTCTTGTATGTTTTGAAACT CTTGTATTTATGATATAGCTTATATGATTTTTTTGCCTTGGTATACATTTTAAAATATGA ATTTAAAAAATTTTTGTAAAAATAAAATTCACAAAATTGTTTTGAAAAACAAAAAAAAAA AAAA |
Protein Sequence | >317 : length: 1248 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE |