| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2324 |
Name | FLT4 |
Synonym | FLT41|LMPH1A|PCL|VEGFR3;fms-related tyrosine kinase 4;FLT4;fms-related tyrosine kinase 4 |
Definition | FLT-4|VEGFR-3|fms-like tyrosine kinase 4|soluble VEGFR3 variant 1|soluble VEGFR3 variant 2|soluble VEGFR3 variant 3|tyrosine-protein kinase receptor FLT4|vascular endothelial growth factor receptor 3 |
Position | 5q35.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Signaling by VEGF;Reactome;REACT:12529 |
Pathway | VEGF binds to VEGFR leading to receptor dimerization;PID Reactome;500649 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Disease | Hemangioma, capillary infantile, somatic;OMIM |
Disease | Lymphedema, hereditary I;OMIM |
External Links | |
Links to Entrez Gene | 2324 |
Links to all GeneRIF Items | 2324 |
Links to iHOP | 2324 |
Sequence Information | |
Nucleotide Sequence | >2324 : length: 6042 AAGGGACTGCTGTAAATGAGCCTTCAGGGCCCCCCCCAACTCACCCACAAGATAAGCACC AGCTTCTTGGGCTCGTGGTACCGGCCCTTCCTGCTGGAGTCCCAGGCCATCCCTAGCCCC GCGTCCACCCAGCCTCCACCCACTGCACACACCAGCCCCAGCACCATGGCCTTTCGCCCA CCCTGGACGTGCCCTTTGGGAGACTGCTGGGAACTCCGGGCAGACGGTGCTGCTCCAAGC GGAAGGGGCCTTCCGGGGCAGGTGATGGCTTCGTTCCCGCTCACAGTGTGCCTCAGACTT TCAGGCCTGGTGAGTGGCTACTCCATGACCCCCCCGACCTTGAACATCACGGAGGAGTCA CACGTCATCGACACCGGTGACAGCCTGTCCATCTCCTGCAGGGGACAGCACCCCCTCGAG TGGGCTTGGCCAGGAGCTCAGGAGGCGCCAGCCACCGGAGACAAGGACAGCGAGGACACG GGGGTGGTGCGAGACTGCGAGGGCACAGACGCCAGGCCCTACTGCAAGGTGTTGCTGCTG CACGAGGTACATGCCAACGACACAGGCAGCTACGTCTGCTACTACAAGTACATCAAGGCA CGCATCGAGGGCACCACGGCCGCCAGCTCCTACGTGTTCGTGAGAGCTTGCTCCCTCTCC ATAGACTTTGAGCAGCCATTCATCAACAAGCCTGACACGCTCTTGGTCAACAGGAAGGAC GCCATGTGGGTGCCCTGTCTGGTGTCCATCCCCGGCCTCAATGTCACGCTGCGCTCGCAA AGCTCGGTGCTGTGGCCAGACGGGCAGGAGGTGGTGTGGGATGACCGGCGGGGCATGCTC GTGTCCACGCCACTGCTGCACGATGCCCTGTACCTGCAGTGCGAGACCACCTGGGGAGAC CAGGACTTCCTTTCCAACCCCTTCCTGGTGCACATCACAGGCAACGAGCTCTATGACATC CAGCTGTTGCCCAGGAAGTCGCTGGAGCTGCTGGTAGGGGAGAAGCTGGTCCTGAACTGC ACCGTGTGGGCTGAGTTTAACTCAGGTGTCACCTTTGACTGGGACTACCCAGGGAAGCAG GCAGAGCGGGGTAAGTGGGTGCCCGAGCGACGCTCCCAGCAGACCCACACAGAACTCTCC AGCATCCTGACCATCCACAACGTCAGCCAGCACGACCTGGGCTCGTATGTGTGCAAGGCC AACAACGGCATCCAGCGATTTCGGGAGAGCACCGAGGTCATTGTGCATGAAAATCCCTTC ATCAGCGTCGAGTGGCTCAAAGGACCCATCCTGGAGGCCACGGCAGGAGACGAGCTGGTG AAGCTGCCCGTGAAGCTGGCAGCGTACCCCCCGCCCGAGTTCCAGTGGTACAAGGATGGA AAGGCACTGTCCGGGCGCCACAGTCCACATGCCCTGGTGCTCAAGGAGGTGACAGAGGCC AGCACAGGCACCTACACCCTCGCCCTGTGGAACTCCGCTGCTGGCCTGAGGCGCAACATC AGCCTGGAGCTGGTGGTGAATGTGCCCCCCCAGATACATGAGAAGGAGGCCTCCTCCCCC AGCATCTACTCGCGTCACAGCCGCCAGGCCCTCACCTGCACGGCCTACGGGGTGCCCCTG CCTCTCAGCATCCAGTGGCACTGGCGGCCCTGGACACCCTGCAAGATGTTTGCCCAGCGT AGTCTCCGGCGGCGGCAGCAGCAAGACCTCATGCCACAGTGCCGTGACTGGAGGGCGGTG ACCACGCAGGATGCCGTGAACCCCATCGAGAGCCTGGACACCTGGACCGAGTTTGTGGAG GGAAAGAATAAGACTGTGAGCAAGCTGGTGATCCAGAATGCCAACGTGTCTGCCATGTAC AAGTGTGTGGTCTCCAACAAGGTGGGCCAGGATGAGCGGCTCATCTACTTCTATGTGACC ACCATCCCCGACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAG CCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACGAGCATCTGCGCTGGTACCGC CTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAAC GTGCATCTGTTCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGC CACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCGAGCACGAGGGCCACTATGTG TGCGAAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTG CAGGCCCTGGAAGCCCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGC GACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACGCGCCCAGCATCGTGTGGTAC AAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAG CTGAGCATCCAGCGCGTGCGCGAGGAGGATGCGGGACGCTATCTGTGCAGCGTGTGCAAC GCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGGAAGGCTCCGAGGATAAGGGC AGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTC CTCCTCCTCATCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTAC CTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGGAGCAATGCGAATACCTGTCC TACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGC TACGGCGCCTTCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGC TGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCACGGCCAGCGAGCACCGCGCG CTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTC CTCGGGGCGTGCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTAC GGCAACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCTTCAGCCCCTGCGCGGAGAAG TCTCCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGG CGGCCGGGGAGCAGCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCG AGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACCTGTGGCTGAGCCCGCTGACCATGGAA GATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAG TGCATCCACAGAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAG ATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACCCCGACTACGTCCGCAAGGGC AGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACC ACGCAGAGTGACGTGTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCC TCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCCAGCGGCTGAGAGACGGCACA AGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATCATGCTGAACTGCTGG TCCGGAGACCCCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCCTGGGGGACCTG CTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCATGGCCCCGCGCAGCTCTCAG AGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCT GACGCTGAGGACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAAC TGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGACCCGTGGTTCCTCCAGGATG AAGACATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAG ACAGACAGTGGGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGA CAAGAAAGCGGCTTCAGCTGTAAAGGACCTGGCCAGAATGTGGCTGTGACCAGGGCACAC CCTGACTCCCAAGGGAGGCGGCGGCGGCCTGAGCGGGGGGCCCGAGGAGGCCAGGTGTTT TACAACAGCGAGTATGGGGAGCTGTCGGAGCCAAGCGAGGAGGACCACTGCTCCCCGTCT GCCCGCGTGACTTTCTTCACAGACAACAGCTACTAAGCAGCATCGGACAAGACCCCCAGC ACTTGGGGGTTCAGGCCCGGCAGGGCGGGCAGAGGGCTGGAGGCCCAGGCTGGGAACTCA TCTGGTTGAACTCTGGTGGCACAGGAGTGTCCTCTTCCCTCTCTGCAGACTTCCCAGCTA GGAAGAGCAGGACTCCAGGCCCAAGGCTCCCGGAATTCCGTCACCACGACTGGCCAGGGC CACGCTCCAGCTGCCCCGGCCCCTCCCCCTGAGATTCAGATGTCATTTAGTTCAGCATCC GCAGGTGCTGGTCCCGGGGCCAGCACTTCCATGGGAATGTCTCTTTGGCGACCTCCTTTC ATCACACTGGGTGGTGGCCTGGTCCCTGTTTTCCCACGAGGAATCTGTGGGTCTGGGAGT CACACAGTGTTGGAGGTTAAGGCATACGAGAGCAGAGGTCTCCCAAACGCCCTTTCCTCC TCAGGCACACAGCTACTCTCCCCACGAGGGCTGGCTGGCCTCACCCACCCCTGCACAGTT GAAGGGAGGGGCTGTGTTTCCATCTCAAAGAAGGCATTTGCAGGGTCCTCTTCTGGGCCT GACCAAACAGCCAACTAGCCCCTGGGGTGGCCACCAGTATGACAGTATTATACGCTGGCA ACACAGAGGCAGCCCGCACACCTGCGCCTGGGTGTTGAGAGCCATCCTGCAAGTCTTTTT CAACAGAACTTCACAGACTGTTAGAGCTGCTGAGAAGAATTTGCTTTCCGAATTCAGCCT GGAAGGCGCCCAGGGACAGCTGTACTGAGTCTAGATGACTCTGACCCCCGCCCCAGGTCA AGGCCAGCAGAGCAGTCAGTGCCTCTGGAGAAGGCCCTTGCTCTCCCACCTGGCCCAGAC TCCGAGGAGCCTGGGTCTGGAGCTGCCGGTCTGGTTCTTCCCTTTAGAGCCCGGATCTGC CACCTGCGGCCCCTCCCAAGCCGTGAACCAGCTCATGAGAGATGAACACTGTGGGATCCA CTCAGGAAGGCTCGGGGCTGGCACAAAGGACCACCCAGCATTGCCCTGTGCCACCCAGCA CTCAGTGGACATTCTGGGGACCTGCCTTCAGCCTTTTCCTGCCCTGTGCCTGACATCAGC ACCCTGGCTGGTCAGAATGCCGCCCTCCCAGAGGAGCAGCCGAGAGATCCCCTGAAGGCT GGAGGCATTCTGCTCAGGACCCCTATCCCAGCTCACAGTGCCCAACCATCTCACCAGGAG AAAGAGCCACATCCCCACGTTAGGACCACGGAGACTGACCACCACCCTGACCCCCCAAAC CCACGCACCAGACGCTTGCAGGACAGGCGCCGCGCAGCGGGCAGGGGCTTGCCCGGCCGA CCCTCCCCTCCCCACCTCCCCCACTGCGCGTTACTCCAGGATATGCCGAGTGCACGTATA AGGTCATCTTCGTCGTCCCCGTGGACCTCCCCCTTCCTCTGCACGTCGTCCAACGTGGGA CTGGCGTGTCAGGCTTCCCTGGGAGGATCTGGAGGTTGTTCTCTGCAGAGAACCAGCCTG GCTCCTGGCGCGCACCTCTGCTCCCTTCTCCTCACTACCCACCCACGCATGTACCGGGAA AAAAACTACTATGCCCTTCTAGACCATGTTCTGAGAAAAGATCGAAAATATTTAACAAGA GATAATAATAAATCTGATGCCGGTCTTTGTGTGTGTTGCGGA |
Protein Sequence | >2324 : length: 1446 MSLQGPPQLTHKISTSFLGSWYRPFLLESQAIPSPASTQPPPTAHTSPSTMAFRPPWTCP LGDCWELRADGAAPSGRGLPGQVMASFPLTVCLRLSGLVSGYSMTPPTLNITEESHVIDT GDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHA NDTGSYVCYYKYIKARIEGTTAASSYVFVRACSLSIDFEQPFINKPDTLLVNRKDAMWVP CLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLS NPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQAERGK WVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISVEW LKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTY TLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQ WHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKNKT VSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLS CQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLS LSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEM QCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCV NSSASVAVEGSEDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIM DPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVA VKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSN FLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASP DQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFG LARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPG VQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRG LQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVSFP GCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGF SCKGPGQNVAVTRAHPDSQGRRRRPERGARGGQVFYNSEYGELSEPSEEDHCSPSARVTF FTDNSY |