| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2222 |
Name | FDFT1 |
Synonym | DGPT|ERG9|SQS|SS;farnesyl-diphosphate farnesyltransferase 1;FDFT1;farnesyl-diphosphate farnesyltransferase 1 |
Definition | FPP:FPP farnesyltransferase|presqualene-di-diphosphate synthase|squalene synthase|squalene synthetase |
Position | 8p23.1-p22 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | cholesterol biosynthesis II (via 24,25-dihydrolanosterol);BioCyc;PWY66-3 |
Pathway | cholesterol biosynthesis I;BioCyc;PWY66-341 |
Pathway | epoxysqualene biosynthesis;BioCyc;PWY-5670 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Steroid biosynthesis;KEGG PATHWAY;hsa00100 |
Pathway | Cholesterol biosynthesis;PANTHER;P00014 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | cholesterol biosynthesis III (via desmosterol);BioCyc;PWY66-4 |
Disease | Non-alcoholic fatty liver disease histology (other);NHGRI |
Disease | Non-alcoholic fatty liver disease histology (lobular);NHGRI |
Disease | Prostate cancer;FunDO |
External Links | |
Links to Entrez Gene | 2222 |
Links to all GeneRIF Items | 2222 |
Links to iHOP | 2222 |
Sequence Information | |
Nucleotide Sequence | >2222 : length: 2681 AAAAACGGTGGCAACACGCTGGGTTTGCTTTACAACGCTTGGGAAGCTTTGTTGTTTGCA ATAAATTTTAATACTTGTCTGTTTCGGTCTGCACTGCCTTTATGAGCTGTAACACTCACA GGGTAGGTTTGCAGCTTCACTCCTGAAGCCAGTAAGACAACGAACCCACTGGGAGAAACA AACAACTCCAGACGCGCCGACTTAAGAGCTGTAATACTCGCTGTGACGGTCTGCAGCTTC ACTCCTGAGCCAGCGAGACCACGAACCCACCAGAAGGAAGAAACTCCGAACACATCTGAA CATCAGAAGGAACAGACTCCGGACACGCCGCCTTTAAGAACTGTAACACTCACCGCGAGG GTGGGCGGTTTCATTCCTGAAGTCAGTGAGACCAAGAACCAACCAATTCCGGACACACTT GGACTCGACAGACTCTAAGGCTCTACAGAGAGCGGCTGCAGAGCTCACCCGGCTGGCAGG AGCCACCGAGGCCGGACACGTGGGCGACTTATTGACCAAGTGGGGAGGAAGCAGCCCCGC ACTGCTCTCCCGACTGCGGACCACCGTTGGGCTCCTGCGCATCCTAAGCCCCACCGCCTC ACCTCCAGTCCCCACAGCGTTCGCGCTCCCAGCCGGGGTCCAGCCGGCCGGTGAGCGCCT GGGGACCGCAGAGGTGAGAGTCGCGCCCGGGAGTCCGCCGCCTGCGCCAGGATGGAGTTC GTGAAATGCCTTGGCCACCCCGAAGAGTTCTACAACCTGGTGCGCTTCCGGATCGGGGGC AAGCGGAAGGTGATGCCCAAGATGGACCAGGACTCGCTCAGCAGCAGCCTGAAAACTTGC TACAAGTATCTCAATCAGACCAGTCGCAGTTTCGCAGCTGTTATCCAGGCGCTGGATGGG GAAATGCGCAACGCAGTGTGCATATTTTATCTGGTTCTCCGAGCTCTGGACACACTGGAA GATGACATGACCATCAGTGTGGAAAAGAAGGTCCCGCTGTTACACAACTTTCACTCTTTC CTTTACCAACCAGACTGGCGGTTCATGGAGAGCAAGGAGAAGGATCGCCAGGTGCTGGAG GACTTCCCAACGATCTCCCTTGAGTTTAGAAATCTGGCTGAGAAATACCAAACAGTGATT GCCGACATTTGCCGGAGAATGGGCATTGGGATGGCAGAGTTTTTGGATAAGCATGTGACC TCTGAACAGGAGTGGGACAAGTACTGCCACTATGTTGCTGGGCTGGTCGGAATTGGCCTT TCCCGTCTTTTCTCAGCCTCAGAGTTTGAAGACCCCTTAGTTGGTGAAGATACAGAACGT GCCAACTCTATGGGCCTGTTTCTGCAGAAAACAAACATCATCCGTGACTATCTGGAAGAC CAGCAAGGAGGAAGAGAGTTCTGGCCTCAAGAGGTTTGGAGCAGGTATGTTAAGAAGTTA GGGGATTTTGCTAAGCCGGAGAATATTGACTTGGCCGTGCAGTGCCTGAATGAACTTATA ACCAATGCACTGCACCACATCCCAGATGTCATCACCTACCTTTCGAGACTCAGAAACCAG AGTGTGTTTAACTTCTGTGCTATTCCACAGGTGATGGCCATTGCCACTTTGGCTGCCTGT TATAATAACCAGCAGGTGTTCAAAGGGGCAGTGAAGATTCGGAAAGGGCAAGCAGTGACC CTGATGATGGATGCCACCAATATGCCAGCTGTCAAAGCCATCATATATCAGTATATGGAA GAGATTTATCATAGAATCCCCGACTCAGACCCATCTTCTAGCAAAACAAGGCAGATCATC TCCACCATCCGGACGCAGAATCTTCCCAACTGTCAGCTGATTTCCCGAAGCCACTACTCC CCCATCTACCTGTCGTTTGTCATGCTTTTGGCTGCCCTGAGCTGGCAGTACCTGACCACT CTCTCCCAGGTAACAGAAGACTATGTTCAGACTGGAGAACACTGATCCCAAATTTGTCCA TAGCTGAAGTCCACCATAAAGTGGATTTACTTTTTTTCTTTAAGGATGGATGTTGTGTTC TCTTTATTTTTTTCCTACTACTTTAATCCCTAAAAGAACGCTGTGTGGCTGGGACCTTTA GGAAAGTGAAATGCAGGTGAGAAGAACCTAAACATGAAAGGAAAGGGTGCCTCATCCCAG CAACCTGTCCTTGTGGGTGATGATCACTGTGCTGCTTGTGGCTCATGGCAGAGCATTCAG TGCCACGGTTTAGGTGAAGTCGCTGCATATGTGACTGTCATGAGATCCTACTTAGTATGA TCCTGGCTAGAATGATAATTAAAAGTATTTAATTTGAAGCACCATTTGAATGTTCGTAAT AGTAGAAAATGATGTGAATTTTCTTTCTGTTCGGCTCCTATTTTTCTCATCATTTTGTTT TCTTTAATTGGGTTGAATGGAGTAGATAGAAATATTTATGGTTTAGGTAACAGTTAGATG TTTCCTAAGAATGCAAACTGCCTTTTCCACACAAAGGCTGGGAATAAAATTCTGGGTATT CTCGTATTCTCATTTAAAGGAGTTTAGCTTTCAGAGAGAAACAGCAGGATTGCTTTTGAC CTTTTAGAAGATTGGTCTCCAGTAAAGGTGGACATTTTTGAGATTTTTATAATAAAGAAT TTAATTGCTCTGCATTTGTCAAGTAAAAAAAAAAAAAAAAA |
Protein Sequence | >2222 : length: 476 MAAAACGTKAMALFKRTLVLSPAAAPRGPGAGTAPRGCCLPPAAWPCKDWPRGEGGRLWS RLPQSHSHSHSHSHSHSCSSTSPTAVCVVCPQDSLSSSLKTCYKYLNQTSRSFAAVIQAL DGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQV LEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGI GLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYVK KLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLA ACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTRQ IISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH |