| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1806 |
Name | DPYD |
Synonym | DHP|DHPDHASE|DPD;dihydropyrimidine dehydrogenase;DPYD;dihydropyrimidine dehydrogenase |
Definition | dihydropyrimidine dehydrogenase [NADP(+)]|dihydrothymine dehydrogenase|dihydrouracil dehydrogenase |
Position | 1p22 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Pyrimidine catabolism;PID Reactome;500232 |
Pathway | Pantothenate and CoA biosynthesis;KEGG PATHWAY;hsa00770 |
Pathway | beta-Alanine metabolism;KEGG PATHWAY;hsa00410 |
Pathway | Pyrimidine Metabolism;PANTHER;P02771 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Pyrimidine metabolism;KEGG PATHWAY;hsa00240 |
Pathway | Drug metabolism - other enzymes;KEGG PATHWAY;hsa00983 |
Pathway | Metabolism of nucleotides;Reactome;REACT:1698 |
Disease | Inherited disorders of nucleotide metabolism;KEGG DISEASE |
Disease | Dihydropyrimidine dehydrogenase deficiency;KEGG DISEASE;H00193 |
Disease | 5-fluorouracil toxicity;OMIM |
Disease | Genetic disorders;KEGG DISEASE |
Disease | 5-fluorouracil toxicity;GAD |
Disease | 5-flurouracil toxicity;GAD |
Disease | Dihydropyrimidine dehydrogenase deficiency;OMIM |
Disease | 5-fluorouracil- related toxicity;GAD |
Disease | PHARMACOGENOMIC;GAD |
External Links | |
Links to Entrez Gene | 1806 |
Links to all GeneRIF Items | 1806 |
Links to iHOP | 1806 |
Sequence Information | |
Nucleotide Sequence | >1806 : length: 4451 GCTCCGCCCCCGCGCCGCCGGCCCTAGTCTGCCTGTTTTCGACTCGCGCTCCGGCTGCTG TCACTTGGCTCTCTGGCTGGAGCTTGAGGACGCAAGGAGGGTTTGTCACTGGCAGACTCG AGACTGTAGGCACTGCCATGGCCCCTGTGCTCAGTAAGGACTCGGCGGACATCGAGAGTA TCCTGGCTTTAAATCCTCGAACACAAACTCATGCAACTCTGTGTTCCACTTCGGCCAAGA AATTAGACAAGAAACATTGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGTGAGAAGC TGGAGAATAATTTTGATGACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAG AAGCAATGAGATGCCTGAAATGTGCAGATGCCCCGTGTCAGAAGAGCTGTCCAACTAATC TTGATATTAAATCATTCATCACAAGTATTGCAAACAAGAACTATTATGGAGCTGCTAAGA TGATATTTTCTGACAACCCACTTGGTCTGACTTGTGGAATGGTATGTCCAACCTCTGATC TTTGTGTAGGTGGATGCAATTTATATGCCACTGAAGAGGGACCCATTAATATTGGTGGAT TGCAGCAATTTGCTACTGAGGTATTCAAAGCAATGAGTATCCCACAGATCAGAAATCCTT CGCTGCCTCCCCCAGAAAAAATGTCTGAAGCCTATTCTGCAAAGATTGCTCTTTTTGGTG CTGGGCCTGCAAGTATAAGTTGTGCTTCCTTTTTGGCTCGATTGGGGTACTCTGACATCA CTATATTTGAAAAACAAGAATATGTTGGTGGTTTAAGTACTTCTGAAATTCCTCAGTTCC GGCTGCCGTATGATGTAGTGAATTTTGAGATTGAGCTAATGAAGGACCTTGGTGTAAAGA TAATTTGCGGTAAAAGCCTTTCAGTGAATGAAATGACTCTTAGCACTTTGAAAGAAAAAG GCTACAAAGCTGCTTTCATTGGAATAGGTTTGCCAGAACCCAATAAAGATGCCATCTTCC AAGGCCTGACGCAGGACCAGGGGTTTTATACATCCAAAGACTTTTTGCCACTTGTAGCCA AAGGCAGTAAAGCAGGAATGTGCGCCTGTCACTCTCCATTGCCATCGATACGGGGAGTCG TGATTGTACTTGGAGCTGGAGACACTGCCTTTGACTGTGCAACATCTGCTCTACGTTGTG GAGCTCGCCGTGTGTTCATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTG AGGAGATGGAACTTGCTAAGGAAGAAAAGTGTGAATTTCTGCCATTCCTGTCCCCACGGA AGGTTATAGTAAAAGGTGGGAGAATTGTTGCTATGCAGTTTGTTCGGACAGAGCAAGATG AAACTGGAAAATGGAATGAAGATGAAGATCAGATGGTCCATCTGAAAGCCGATGTGGTCA TCAGTGCCTTTGGTTCAGTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAA AATTTAACAGATGGGGTCTCCCAGAAGTAGATCCAGAAACTATGCAAACTAGTGAAGCAT GGGTATTTGCAGGTGGTGATGTCGTTGGTTTGGCTAACACTACAGTGGAATCGGTGAATG ATGGAAAGCAAGCTTCTTGGTACATTCACAAATACGTACAGTCACAATATGGAGCTTCCG TTTCTGCCAAGCCTGAACTACCCCTCTTTTACACTCCTATTGATCTGGTGGACATTAGTG TAGAAATGGCCGGATTGAAGTTTATAAATCCTTTTGGTCTTGCTAGCGCAACTCCAGCCA CCAGCACATCAATGATTCGAAGAGCTTTTGAAGCTGGATGGGGTTTTGCCCTCACCAAAA CTTTCTCTCTTGATAAGGACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCA CCTCTGGCCCCATGTATGGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTG AGAAAACGGCTGCATATTGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTTCCAGACA ACATTGTGATTGCTAGCATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCA AGAAGTCTGAGGATTCTGGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCA TGGGAGAAAGAGGAATGGGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCT GCCGCTGGGTTAGGCAAGCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCA CTGATATTGTGAGCATCGCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCA CCAACACTGTCTCAGGTCTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGG GGATTGCAAAGCGAACTACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTT TGAGAGCTGTGACCTCCATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTG GAATTGACTCTGCTGAAAGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGG TATGCAGTGCCATTCAGAATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCA AAGCCCTGCTTTATCTGAAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAG CTACTGTGAGTCACCAGAAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGA AACTGCCAAGTTTTGGACCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGA TTAGACTGAAAGAACAAAATGTAGCTTTTTCACCACTTAAGAGAAACTGTTTTATCCCCA AAAGGCCTATTCCTACCATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACAT TTGGTGAATTGAGCAACGTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCA ACTGTGGTAAATGCTACATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATC CAGAAACCCACCTGCCCACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTG TTTGCCCTATTGTCGACTGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGA GAGGCGTACCCTTATCTGTGAATCCGGTGTGTTAAGGTGATTTGTGAAACAGTTGCTGTG AACTTTCATGTCACCTACATATGCTGATCTTTTAAAATCATGATCCTTGTGTTCAGCTCT TTCCAAATTAAAACAAATATACATTTTCTAAATAAAAATATGTAATTTCAAAATACATTT GTAAGTGTAAAAAATGTCTCATGTCAATGACCATTCAATTAGTGGTCATAAAATAGAATA ATTCTTTTCTGAGGATAGTAGTTAAATAACTGTGTGGCAGTTAATTGGATGTTCACTGCC AGTTGTCTTATGTGAAAAATTAACTTTTTTGTGGCAATTAGTGTGACAGTTTCCAAATTG CCCTATGCTGTGCTCCATATTTGATTTCTAATTGTAAGTGAAATTAAGCATTTTGAAACA AAGTACTCTTTAACATACAAGAAAATGTATCCAAGGAAACATTTTATCATTAAAAATTAC CTTTAATTTTAATGCTGTTTCTAAGAAAATGTAGTTAGCTCCATAAAGTACAAATGAAGA AAGTCAAAAAATTATTTGCTATGGCAGGATAAGAAAGCCTAAAATTGAGTTTGTAGAACT TTATTAAGTAAAATCCCCTTCGCTGAAATTGCTTATTTTTGGTGTTGGATAGAGGATAGG GAGAATATTTACTAACTAAATACCATTCACTACTCATGCGTGAGATGGGTGTACAAACTC ATCCTCTTTTAATGGCATTTCTCTTTAAACTATGTTCCTAACAAAATGAGATGATAGGAT AGATCCTGGTTACCACTCTTTTGCTGTGCACATACGGGCTCTGACTGGTTTTAATAGTCA CCTTCATGATTATAGCAACTAATGTTTGAACAAAGCTCAAAGTATGCAATGCTTCATTAT TCAAGAATGAAAAATATAATGTTGATAATATATATTAAGTGTGCCAAATCAGTTTGACTA CTCTCTGTTTTAGTGTTTATGTTTAAAAGAAATATATTTTTTGTTATTATTAGATAATAT TTTTGTATTTCTCTATTTTCATAATCAGTAAATAGTGTCATATAAACTCATTTATCTCCT CTTCATGGCATCTTCAATATGAATCTATAAGTAGTAAATCAGAAAGTAACAATCTATGGC TTATTTCTATGACAAATTCAAGAGCTAGAAAAATAAAATGTTTCATTATGCACTTTTAGA AATGCATATTTGCCACAAAACCTGTATTACTGAATAATATCAAATAAAATATCATAAAGC ATTTTAAAAAA |
Protein Sequence | >1806 : length: 1025 MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ NVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS VNPVC |