| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1540 |
Name | CYLD |
Synonym | BRSS|CDMT|CYLD1|CYLDI|EAC|MFT|MFT1|SBS|TEM|USPL2;cylindromatosis (turban tumor syndrome);CYLD;cylindromatosis (turban tumor syndrome) |
Definition | deubiquitinating enzyme CYLD|probable ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin carboxyl-terminal hydrolase CYLD|ubiquitin specific peptidase like 2|ubiquitin thioesterase CYLD|ubiquitin thiolesterase CYLD|ubiquitin-specific-processing protease |
Position | 16q12.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Disease | Multiple familial trichoepithelioma and familial cylindromatosis;GAD |
Disease | Infectious lung disease;FunDO |
Disease | Spiegler-Brooke syndrome;OMIM |
Disease | Multiple myeloma;FunDO |
Disease | CANCER;GAD |
Disease | Cylindromatosis, familial;OMIM |
Disease | Trichoepithelioma, multiple familial, 1;OMIM |
Disease | Hodgkin's disease;FunDO |
Disease | Liver cancer;FunDO |
Disease | Adenoid cystic cancer;FunDO |
Disease | Brooke-Spiegler syndrome;OMIM |
External Links | |
Links to Entrez Gene | 1540 |
Links to all GeneRIF Items | 1540 |
Links to iHOP | 1540 |
Sequence Information | |
Nucleotide Sequence | >1540 : length: 8730 GTGCGGTTCGGAGGCGGGGCAGGTGGGGGCGGGCCCAGGTAGCAGGTTTGGCTGCGCGGG GGCCGCGCGTCGGAGTTTCCCCCTTTCTAGGGTGAGGATGGTTCTACACAGCCACCCGGA GTTCCTTAGTTGAAAGGTGCGCCCTGCTGTGACAGAATGTGGTAATTGTAATCTTTAACA TTTTCATGTAAAACATATTTCCTGATCATCTTTCCATTGTCTTCATGGAAAATTGATAAA TATTTGTGCCTTCCAACTCTCGTCTTGGTTGAATGACTTCATCTTAATACAACATGGACA CCACGTTGCTGAAAACATGCTTTGGGACTGCCACTGAATTTATCTTTTGCGGTTTTATGA CAAAGTTATTAGTAGTTTCCCTTTTTTGAATTAGTATTTTGAAGTTAATATCACAATGAG TTCAGGCTTATGGAGCCAAGAAAAAGTCACTTCACCCTACTGGGAAGAGCGGATTTTTTA CTTGCTTCTTCAAGAATGCAGCGTTACAGACAAACAAACACAAAAGCTCCTTAAAGTACC GAAGGGAAGTATAGGACAGTATATTCAAGATCGTTCTGTGGGGCATTCAAGGATTCCTTC TGCAAAAGGCAAGAAAAATCAGATTGGATTAAAAATTCTAGAGCAACCTCATGCAGTTCT CTTTGTTGATGAAAAGGATGTTGTAGAGATAAATGAAAAGTTCACAGAGTTACTTTTGGC AATTACCAATTGTGAGGAGAGGTTCAGCCTGTTTAAAAACAGAAACAGACTAAGTAAAGG CCTCCAAATAGACGTGGGCTGTCCTGTGAAAGTACAGCTGAGATCTGGGGAAGAAAAATT TCCTGGAGTTGTACGCTTCAGAGGACCCCTGTTAGCAGAGAGGACAGTCTCCGGAATATT CTTTGGAGTTGAATTGCTGGAAGAAGGTCGTGGTCAAGGTTTCACTGACGGGGTGTACCA AGGGAAACAGCTTTTTCAGTGTGATGAAGATTGTGGCGTGTTTGTTGCATTGGACAAGCT AGAACTCATAGAAGATGATGACACTGCATTGGAAAGTGATTACGCAGGTCCTGGGGACAC AATGCAGGTCGAACTTCCTCCTTTGGAAATAAACTCCAGAGTTTCTTTGAAGGTTGGAGA AACAATAGAATCTGGAACAGTTATATTCTGTGATGTTTTGCCAGGAAAAGAAAGCTTAGG ATATTTTGTTGGTGTGGACATGGATAACCCTATTGGCAACTGGGATGGAAGATTTGATGG AGTGCAGCTTTGTAGTTTTGCGTGTGTTGAAAGTACAATTCTATTGCACATCAATGATAT CATCCCAGCTTTATCAGAGAGTGTGACGCAGGAAAGGAGGCCTCCCAAACTTGCCTTTAT GTCAAGAGGTGTTGGGGACAAAGGTTCATCCAGTCATAATAAACCAAAGGCTACAGGATC TACCTCAGACCCTGGAAATAGAAACAGATCTGAATTATTTTATACCTTAAATGGGTCTTC TGTTGACTCACAACCACAATCCAAATCAAAAAATACATGGTACATTGATGAAGTTGCAGA AGACCCTGCAAAATCTCTTACAGAGATATCTACAGACTTTGACCGTTCTTCACCACCACT CCAGCCTCCTCCTGTGAACTCACTGACCACCGAGAACAGATTCCACTCTTTACCATTCAG TCTCACCAAGATGCCCAATACCAATGGAAGTATTGGCCACAGTCCACTTTCTCTGTCAGC CCAGTCTGTAATGGAAGAGCTAAACACTGCACCCGTCCAAGAGAGTCCACCCTTGGCCAT GCCTCCTGGGAACTCACATGGTCTAGAAGTGGGCTCATTGGCTGAAGTTAAGGAGAACCC TCCTTTCTATGGGGTAATCCGTTGGATCGGTCAGCCACCAGGACTGAATGAAGTGCTCGC TGGACTGGAACTGGAAGATGAGTGTGCAGGCTGTACGGATGGAACCTTCAGAGGCACTCG GTATTTCACCTGTGCCCTGAAGAAGGCGCTGTTTGTGAAACTGAAGAGCTGCAGGCCTGA CTCTAGGTTTGCATCATTGCAGCCGGTTTCCAATCAGATTGAGCGCTGTAACTCTTTAGC ATTTGGAGGCTACTTAAGTGAAGTAGTAGAAGAAAATACTCCACCAAAAATGGAAAAAGA AGGCTTGGAGATAATGATTGGGAAGAAGAAAGGCATCCAGGGTCATTACAATTCTTGTTA CTTAGACTCAACCTTATTCTGCTTATTTGCTTTTAGTTCTGTTCTGGACACTGTGTTACT TAGACCCAAAGAAAAGAACGATGTAGAATATTATAGTGAAACCCAAGAGCTACTGAGGAC AGAAATTGTTAATCCTCTGAGAATATATGGATATGTGTGTGCCACAAAAATTATGAAACT GAGGAAAATACTTGAAAAGGTGGAGGCTGCATCAGGATTTACCTCTGAAGAAAAAGATCC TGAGGAATTCTTGAATATTCTGTTTCATCATATTTTAAGGGTAGAACCTTTGCTAAAAAT AAGATCAGCAGGTCAAAAGGTACAAGATTGTTACTTCTATCAAATTTTTATGGAAAAAAA TGAGAAAGTTGGCGTTCCCACAATTCAGCAGTTGTTAGAATGGTCTTTTATCAACAGTAA CCTGAAATTTGCAGAGGCACCATCATGTCTGATTATTCAGATGCCTCGATTTGGAAAAGA CTTTAAACTATTTAAAAAAATTTTTCCTTCTCTGGAATTAAATATAACAGATTTACTTGA AGACACTCCCAGACAGTGCCGGATATGTGGAGGGCTTGCAATGTATGAGTGTAGAGAATG CTACGACGATCCGGACATCTCAGCTGGAAAAATCAAGCAGTTTTGTAAAACCTGCAACAC TCAAGTCCACCTTCATCCGAAGAGGCTGAATCATAAATATAACCCAGTGTCACTTCCCAA AGACTTACCCGACTGGGACTGGAGACACGGCTGCATCCCTTGCCAGAATATGGAGTTATT TGCTGTTCTCTGCATAGAAACAAGCCACTATGTTGCTTTTGTGAAGTATGGGAAGGACGA TTCTGCCTGGCTCTTCTTTGACAGCATGGCCGATCGGGATGGTGGTCAGAATGGCTTCAA CATTCCTCAAGTCACCCCATGCCCAGAAGTAGGAGAGTACTTGAAGATGTCTCTGGAAGA CCTGCATTCCTTGGACTCCAGGAGAATCCAAGGCTGTGCACGAAGACTGCTTTGTGATGC ATATATGTGCATGTACCAGAGTCCAACAATGAGTTTGTACAAATAACTGGGGTCATCGGG AAAGGCAAAGAAACTGAAGGCAGAGTCCTAACGTTGCATCTTATTCGAGCTGGCAGTTCT GTTCACGTCCATTGCCGGCAATGGATGTCTTTGTGGTGATGATCCTTCAGAAAAGGATGC CTCTGTTTAAAAACAAATTGCTTTTGTGTCCCTGAAGTATTTAATAAGAAGCATTTTGCA CTCTAGAAAGTATGTTTGTGTTGGTTTTTTAAGAAGTCTAAATGAAGTTATTAATACCTG AAGCTTTAAGTTAAGTGCATTGATCATATGATATTTTTGGAAGCATACAATTTTAATTGT GGAAGTTTAAAGCCTCTTTTAGTCCATTGAGAATGTAAATAAATGTGTCTTCTTTATGGA CCAAGGATATGAAATCATTTTTCTTTTGTAGCTAACGGTTGCCTTGAGGAAGAAATAATT TGGTTTTATTAAGAGTCTACTCTCAATCCAGTTATTAGAGATGTACTGAGTTTGATTTGT TAATCCTTTCTATATACTGCTGATCTTGCATGTCTACAATCTGCTCAGTTTTTCTGTGTT TCTGCAATAGTGGTCAGAAAAATACTTAAATTCCCTTAATGGTGTTGTTTTCTATTTGTT CTGGTTTTGAGATAAATGAGTGATTCTGTCCCCAAATGTCCATTTTTGAAGTGATTTTCC TGGAGGATTAGGGTATTTAGCAGTTGAAGCTCTTCATTCATAGTAGTTACTGTCAGCTAA CAGGTTTTTTAAGGCTTTTAACTATTAATATTTTATGGAATGGGGCAAAGTAAATTGATG AAAGAATTGGAGTGATAATAGTCCTTTACAAACATACAGTCCATAAGAAAATGAATTTGG CATATAGAATTATTACAATTTCCTGGGAGAGATGGATATTTAAACCTCTATTATTTTAGA CAAGACTGTCTAGAACTTAAGTTTGATCTGTCAGCCAGTACTCCCATTAAATTCAGTGTA GTTTCACTTGATAGAATCAGATATGTTATCGAAATGTTAGCAGCAGCTTCATCCTCCTTC TGATTAAAGTAAGTAGAAATGGGATGTTTTGTTTAATAACAGCCATAGTGTGTGTTTAGA CCACAGCGGATGTTGTAGACCAGGACCATAGATGATACATGTCAGTGCTGTGGAATGTGC ATTCTCTGAGTGTTGTTTTGTGGTATCATTGTCTTTCCTGAATGACTTTCTAACTGTGCA GAAAGGCAGAAAAGTCATCATATGTATATGTCATATGACTTTATAAAATATTTAATGTGA CAAAAAGTGGAAAGAATCTTTACAAACCCTGCAATTACTTTTTTAAAGGCACTTTTACTC TTTGGTTTTATCATTCCATTTTGCTAATATTTACTAGCTTTATAAATTACAGTAAGGTAC AAAAACTCATCTTGTAATATTTTCATTTTTGAAGTGAAAAAGTACATATATTTTGCACAA GGTTTTATACTGCTAAGTGCTTGGTTGGGGTGGTGAGATGATGATTAGATCAGGGGTGAG GCTGAGAGACTCTGGGTTTAGGGCTAGCCCTGCCTCCATCTCCCTTGGGTAAAATGAAGG GTGTGGGGTAAAAGATGCATAAGGCCTTTTCTAGCTCTGACAGCCTAGAAGTCCAATCAC CCTGTAATAAATATGTGTTGAATGAAGAAATGGGTGAATGAGCTTGTCAATGTGATTTTA AAAAATTGACTACCTGGAGGAATGATTAGGAATCTAAATGAAGCCAGCCCTCGGTATCTG CAGGTTTCTCATCCATGGATTCAACCAACTGCAAATGGAAAATACGATTTTTTTTAAAAA AAGGATGGTTACATCCGTATTGAACATGTACAGACTTTTTTCTTGTCATTATTCTCTGAA CAATACAAGAACTCTTTATGTAGCATTTACATTTATTAGGTATTATAAGTAATCTAGAGA TTATTTAATTAAAATATACAGGAGGATGTGTGTCAGTTATATGCAAATTCTGTACCATTT TGTATCAGGGAATTGAGCATCTTCAGATGTTGGTATCTGCAGGGATCCTGGAACCAAACC CCTGCAGATACTAAGGGCTGACGATCTAGGTAAGACTGGATTTAACAGTTGGAAAAAAAA AAAAAAAAGGAGAGAGAAGACAGTTCCTTTCCTGTAGAAATTAAAACAAAATACAAATTG AGGAAGCTCTGCTACCCAGGCTGTCATGGTAGAGAACTTGAAGAAGACCTGTTTGGATGG ACACCTGGTTTCAAAAGTCAGGTGTGGAGACTGTTAAATGGGAGGGCCTCATCCATAAAT GATTTCTGGCAACGTCTTCTTCAGGTGGAGCTTGACGTCTTTTTAATGTTACTTGGGGAG GGAGTGCTCATTAAGGGATGCCAGGGCCAGCTCTGGTGGTTCCTGGGGAGGCTGCGTCCT TCCCTGCTTCTGCATGTCATGAGGCAGCAGGAAGGTTTCCCCTGCACCTGTCTGTCCTGG CTCCCTCTGGGTAGCCCCCTACTGTTCTGTGCTTCAGCACAGCCTGGTTTGTCAAGAGGC ACATAGTTGGGGCTGGGCTGCATGGCACAGGGGCTTATGTGCCTGCTGGTTATTTAATTT TCAGCCTTAAGTTTTCTTTAATATTTTCCTGTTGGCTATTTAAAGGTTTTGGTTATCTTT TATTCCTTATCTACAATCAAGATGACAATGTAATTGAATTATCTTATTTATAACACGGTT CGTGATTCATGATTCATGATTACAAGTAGAAAATATGTCATGTTCCTCACCTCCAAATAA ATATGTGTGTGTCTGTGTGTGTGTATATATGTATGTGGCGGAGAGGGAGAGAGTGGGGAA GGAGAGCAGTGTTATCATACATAGAGAGGCTAAATGTGTCCCATCCCTCACTGTCAGCTT TATAAAGGAGTTTGACTCCATCCACAGAAGAATGTTTTATAAGACTAGGAAAACACGTTG AAAACTAGGATAAACAGCAACAAAAATCAACTAAATATGTTGTTACTGTTGCTAAGGATT TTCTCCTTAGAATAATTTAGGATTTTTAAAAATTTCTGTTTGCCAAATGCTGTAGATAAA TGGCCAGATTCTTCCTATCCCTAGGATTCCTTTATTATTTTTTTTCACAGATTTTGAGAA CAAGGGGGAGAGATAGTATGGAAGATTAAGATTCCATTAATCTTATAGAACTGTGTTGTC ACCCAAATTCCTGCTTGTTTGAACATGGCATCTTCATAGATTCAGGATTCACTACCCTCT ATAGCTGGATCTTGAAAATTATCTGGCCAGATAATTTTGCATCTGCTTGGATGATTGTAG ACTGAGATGTGAGTGGAGGATAAAGTATTAGACTTTTGCTGAGTAACTGCCAACCAAGAA GTATTTATCGGACACTTACTAGGTGCCTAGGATTGTATCAGAGGGAATATGAAATGTGTC CCTGCCCTACCTAGTTTTAACGACAGAATATCTATTAAAGGCTACTTAGCTGAAGGGTAA GGGTGACAGGTCTAGGGGAAGCTTTGGGAGGTGGTGTGCTGTGACAGAAAAAGTGGCAGA GTAGGGACGAGAGACCTGCATTCTAGCCCTGTTTCTGTCACTTGCTCTGTACACTTAGAC AACAGCTTGACCTCTTGAGCTTTAGTTTCCTCCTCTGCATAATGAGAGGGTTAGACTACT GAATTGTATGGGAAAAAAATACAAATTCCTGGGTCCTAGGCCATGCCTGCTGAATCCGAC TGTTCAGGAAGAGGCCTAGGAAATCTGTGAGGGAATCCCCAGGGGAATCTCGTGACCAGC CAGGTGTGAAATCTGCTAACTGGAAGATCTCAAAGCTTCCTTCACTTTTTGTGATTTTGT GGTCATGTAACGTTACTGTATTATTCTACGTAAATGTGGGTACTTGGATGTTTATCATAC TGTTTCTCTGTGTTTACATACTAATTTGTGTAAGAAATGCATTTTAGTCTGTGTACCTCA ACCTGCTGTTTGTTTCCTAGAGGTGTTAGTAGTCTTTAAATACAAGTAAGACTTAAGAGG ATATTTGATGTTATTTACCTGGATATTTTCTTCCCCTTTTATTTATTTAGAGGAAATTGA GATTCTAGGAGCCAAAAAAATGAAAACAAAATTCTAAGGCAAAGTTAAAGAAAAAAATTA CATTATTTCTTACCATTTGCTACTTTATAATGAAAATTTAAAAATTATATGGGAAGATTT TTCTCTGGGATAACAAATCCTTGTCATAAAGTAAGAGGTCTTTTTAAAGTAGGTAGGCTA TAAGGCCTGTAATTTAAAATAATACTCCTTTCTCTAGGGTTTGGTGCAATTCTCCATTAA TGAAGATAACATTTGAATTCCCCAAAGCAGGTGAGGAGTCGGGGAGGAGAAAGCGATGTT AAAATGAAAACTCACTGCAAAAGAGGAGGCAGAGGAAGAAGGAATGTAAACCCCTTAAAG CAGATGTGTGTGGGGCCTTATGAAGACCAGGATTCTGCGGGTGTCAGGGGATTGCCCCTC TTGACAGAGACTAGGGTTTTAGACTGAGGCTTCCTGCAGGGTGTTCGCATTGCCCTTCTC CGTTCCCCTTCAGACCTTTCTGGGGAGAAGAGGTGGGAGGAGGGGAGAAAGACTGTTCAT CTTATTCTGAATCCTGGAGCAGCTGAAGGTTTTCTCTTGAGTCAGGATGCAGTGGTAATG CATTAACCAGCAAGTGTGGCCAAGGATAATGAAAAAGTGGGAAAGGAAGGTCCTCCTCCT CCCTGATTGTAGCATCCAGCAGTCTCTGTAGCCAGGTTACTCAAGAACCACATTTGATTT CCTGGCCCTTTGCCTTGGCAGTGATGGCATTTTTATTTCACTGTGTTTTAAAGTCTTCAT TTATTTTTATAACATGGGTTAGGGAGAAGGGCCACAAATGGAGGGATTGTCCTTTCAAGC ACCACAGCTTCAGATAAAATTAGTACTTTCAAATATTGTCCACTTTAACTTAAAAAATTC TAGAGGGATTATATTGGAGACTCAACTGCCCTTGGTTTTAGTTTATAAAATGGCCTAGTA CTGTGGAATTTTAATTTTAGAAAGTCTTAGCATCAGATCATAAACATTCATTAAAAGAAC TCACATCCCATCTGAAACTTCCCAGGGGAGTTGGGATTCTTAGTAGATTGGTAGAAAGGG GCTCATTTTCTACTGCATTTCCCATTTTTGGTATCTTGTTCAGCATGTTTTATTTTTATT TCTTGTCTGCAGAACATCCTATATTTATGAGAACATTCTTTAAGAAGACCACCACATAGA ATACCCCTTCCTATCAGCTCGCTCTGATTTAGCCTTAATTTTGTTAAATTTTTTAGAGAT GAATGAAGTGCTGCTGTGGAAAGAAATGTACATATACTATTTCTGTATCATTAAAATTAC ATTTTTATGGTTCAAAAAAAAAAAAAAAAA |
Protein Sequence | >1540 : length: 956 MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRI PSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERFSLFKNRNRLS KGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKV GETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFACVESTILLHIN DIIPALSESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTSDPGNRNRSELFYTLNG SSVDSQPQSKSKNTWYIDEVAEDPAKSLTEISTDFDRSSPPLQPPPVNSLTTENRFHSLP FSLTKMPNTNGSIGHSPLSLSAQSVMEELNTAPVQESPPLAMPPGNSHGLEVGSLAEVKE NPPFYGVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCR PDSRFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNS CYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIM KLRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFME KNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDL LEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSL PKDLPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNG FNIPQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK |